Class information for:
Level 1: RETIGABINE//FLUPIRTINE//KCNQ

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
10908 957 39.4 85%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
547 13910 SCORPION TOXINS//SCORPION VENOM//POTASSIUM CHANNEL

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 RETIGABINE Author keyword 160 81% 10% 97
2 FLUPIRTINE Author keyword 115 79% 8% 73
3 KCNQ Author keyword 73 61% 8% 78
4 M CURRENT Author keyword 73 53% 10% 97
5 BFNC Author keyword 65 95% 2% 21
6 KCNQ2 Author keyword 54 76% 4% 38
7 EZOGABINE Author keyword 51 91% 2% 21
8 LINOPIRDINE Author keyword 50 77% 4% 34
9 KV7 Author keyword 46 72% 4% 36
10 KCNQ CHANNELS Author keyword 33 75% 3% 24

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 RETIGABINE 160 81% 10% 97 Search RETIGABINE Search RETIGABINE
2 FLUPIRTINE 115 79% 8% 73 Search FLUPIRTINE Search FLUPIRTINE
3 KCNQ 73 61% 8% 78 Search KCNQ Search KCNQ
4 M CURRENT 73 53% 10% 97 Search M+CURRENT Search M+CURRENT
5 BFNC 65 95% 2% 21 Search BFNC Search BFNC
6 KCNQ2 54 76% 4% 38 Search KCNQ2 Search KCNQ2
7 EZOGABINE 51 91% 2% 21 Search EZOGABINE Search EZOGABINE
8 LINOPIRDINE 50 77% 4% 34 Search LINOPIRDINE Search LINOPIRDINE
9 KV7 46 72% 4% 36 Search KV7 Search KV7
10 KCNQ CHANNELS 33 75% 3% 24 Search KCNQ+CHANNELS Search KCNQ+CHANNELS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 ANTICONVULSANT RETIGABINE 327 88% 16% 152
2 D 23129 142 96% 5% 45
3 KV7 CHANNELS 100 90% 5% 44
4 DUP 996 80 90% 4% 35
5 KCNQ2 KCNQ3 K CHANNELS 64 86% 3% 32
6 KCNQ POTASSIUM CHANNELS 62 73% 5% 47
7 KCNQ2 KCNQ3 60 100% 2% 20
8 RETIGABINE 58 73% 5% 45
9 LINOPIRDINE DUP 996 56 80% 4% 35
10 KCNQ2 42 61% 5% 44

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Neural KCNQ (Kv7) channels 2009 183 75 77%
The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy 2012 46 57 81%
Flupirtine, a re-discovered drug, revisited 2013 12 61 74%
Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs 2008 54 72 89%
Pathways modulating neural KCNQ/M (Kv7) potassium channels 2005 288 112 47%
Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data 2012 13 48 85%
Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels 2011 30 110 55%
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders 2013 6 74 84%
Flupirtine in Pain Management Pharmacological Properties and Clinical Use 2010 25 35 89%
Kv7 Channels as Targets for the Treatment of Pain 2009 25 91 89%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 NEW LEADS BIOL 8 100% 0.5% 5
2 ASTA MED GRP 6 58% 0.7% 7
3 ABT MED DEUT LAND 3 100% 0.3% 3
4 PHARMACOL CELL PHYSIOL GRP 2 44% 0.4% 4
5 CNRSUMR 6150 2 67% 0.2% 2
6 NEUROL UNIT S 2 67% 0.2% 2
7 LEHRSTUHL BIOCHEM REZEPTORBIOCHEM 1 1 100% 0.2% 2
8 SECT EARLY TARGET PHARMACOL PHYSIOL 1 100% 0.2% 2
9 WELLCOME MOL PHARMACOL 1 14% 0.8% 8
10 ABT NEUROL WERPUNKT EPILEPTOL 1 24% 0.4% 4

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000133067 DRAVET SYNDROME//SCN1A//GEFS
2 0.0000132724 SYMPATHETIC GANGLION CELLS//M CURRENT//NICOTINIC SYNAPSES
3 0.0000121572 LACOSAMIDE//ESLICARBAZEPINE ACETATE//PERAMPANEL
4 0.0000084366 APAMIN//SK CHANNELS//SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL
5 0.0000072529 LONG QT SYNDROME//KCNQ1//SHORT QT SYNDROME
6 0.0000061182 KCSA//EPISODIC ATAXIA TYPE 1//MOL NEUROBIOL BIOPHYS
7 0.0000061046 PAROXYSMAL KINESIGENIC DYSKINESIA//PRRT2//PAROXYSMAL KINESIGENIC CHOREOATHETOSIS
8 0.0000058194 NODE OF RANVIER//AXON INITIAL SEGMENT//PARANODE
9 0.0000049852 HERG//HUMAN ETHER A GO GO RELATED GENE//HERG CHANNEL
10 0.0000045841 K 2P CHANNEL//K 2P CHANNELS//TREK 1