Class information for:
Level 1: REACTIVE METABOLITE//MASS DEFECT FILTER//TIENILIC ACID

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
13495 769 40.0 77%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
2272 4206 BIOANALYSIS//LC NMR//DRIED BLOOD SPOT DBS

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 REACTIVE METABOLITE Author keyword 10 33% 3% 25
2 MASS DEFECT FILTER Author keyword 7 64% 1% 7
3 TIENILIC ACID Author keyword 7 64% 1% 7
4 REACTIVE METABOLITES Author keyword 5 19% 3% 22
5 CHEMICALLY REACTIVE METABOLITE Author keyword 4 67% 1% 4
6 METABOLITE IDENTIFICATION Author keyword 4 15% 3% 23
7 BIOACTIVATION Author keyword 4 11% 4% 33
8 ICH M3R2 Author keyword 3 100% 0% 3
9 MICROPLATE SCINTILLATION COUNTER Author keyword 3 100% 0% 3
10 DRUG METAB PHARMACOKINET SSHINAGAWA KU Address 2 67% 0% 2

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 REACTIVE METABOLITE 10 33% 3% 25 Search REACTIVE+METABOLITE Search REACTIVE+METABOLITE
2 MASS DEFECT FILTER 7 64% 1% 7 Search MASS+DEFECT+FILTER Search MASS+DEFECT+FILTER
3 TIENILIC ACID 7 64% 1% 7 Search TIENILIC+ACID Search TIENILIC+ACID
4 REACTIVE METABOLITES 5 19% 3% 22 Search REACTIVE+METABOLITES Search REACTIVE+METABOLITES
5 CHEMICALLY REACTIVE METABOLITE 4 67% 1% 4 Search CHEMICALLY+REACTIVE+METABOLITE Search CHEMICALLY+REACTIVE+METABOLITE
6 METABOLITE IDENTIFICATION 4 15% 3% 23 Search METABOLITE+IDENTIFICATION Search METABOLITE+IDENTIFICATION
7 BIOACTIVATION 4 11% 4% 33 Search BIOACTIVATION Search BIOACTIVATION
8 ICH M3R2 3 100% 0% 3 Search ICH+M3R2 Search ICH+M3R2
9 MICROPLATE SCINTILLATION COUNTER 3 100% 0% 3 Search MICROPLATE+SCINTILLATION+COUNTER Search MICROPLATE+SCINTILLATION+COUNTER
10 FENCLOZIC ACID 2 67% 0% 2 Search FENCLOZIC+ACID Search FENCLOZIC+ACID

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 THOROUGH BACKGROUND SUBTRACTION 42 94% 2% 15
2 TRAPPED REACTIVE METABOLITES 38 93% 2% 14
3 LC MS DATA APPLICATION 35 89% 2% 16
4 DEPENDENT COVALENT BINDING 31 92% 2% 12
5 NONHEPATOTOXIC DRUGS 29 75% 3% 21
6 DRUG METABOLITES 28 35% 8% 65
7 ELECTROPHILIC METABOLITES 21 75% 2% 15
8 COVALENT BINDING DATA 18 65% 2% 17
9 REACTIVE METABOLITES 13 19% 8% 60
10 CHARACTERIZING REACTIVE METABOLITES 11 100% 1% 6

Journals

Reviews


Title Publ. year Cit. Active
references		 % act. ref.
to same field
Drug Metabolite Profiling and Identification by High-resolution Mass Spectrometry 2011 43 68 65%
Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary? 2012 20 28 68%
Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS 2013 5 38 87%
Managing the challenge of chemically reactive metabolites in drug development 2011 109 77 26%
Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates 2015 1 65 38%
Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS 2012 26 84 40%
Bioactivation Potential of Thiophene-Containing Drugs 2014 4 62 40%
Addressing the Challenges of Low Clearance in Drug Research 2015 1 17 29%
Application of LC-high-resolution MS with 'intelligent' data mining tools for screening reactive drug metabolites 2012 6 32 91%
Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development 2009 66 41 49%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DRUG METAB PHARMACOKINET SSHINAGAWA KU 2 67% 0.3% 2
2 DRUG METAB PRECLIN SAFETY 2 67% 0.3% 2
3 PHARMACEUT CANDIDATE OPTIMIZAT 2 11% 2.5% 19
4 DMPK TOXICOL 2 43% 0.4% 3
5 MEDIPOLIS 2 28% 0.7% 5
6 ANALYT CHEM DMPK 1 100% 0.3% 2
7 TOXICOKINET BIOTRANSFORMAT 1 50% 0.3% 2
8 DRUG METAB PHARMACOKINET SECT 1 19% 0.7% 5
9 PHARMACOKINET PHARMACODYNAM METAB 1 19% 0.7% 5
10 DRUG METAB SECT 1 33% 0.3% 2

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000258892 ACYL GLUCURONIDES//ACYL GLUCURONIDE//ZOMEPIRAC
2 0.0000172222 BIOANALYSIS//BIOANALYT METAB PHARMACOKINET//CASSETTE ANALYSIS
3 0.0000171504 DISCOVERY ANALYT CHEM CHEM TECHNOL//LC MS TECHNOL DEV//SHANGHAI MASS SPE OMETRY
4 0.0000146868 AGR PROD UTILIZAT//DL BUTHIONINE SULFOXIMINE//DRUG METAB PHARMACOKINET PD TOXICOL
5 0.0000108097 PHARMACOL RE6640//SPP301//AVOSENTAN
6 0.0000093539 ALDEHYDE OXIDASE//RS 8359//AOX1
7 0.0000088247 CYP3A//COCKTAIL//MECHANISM BASED INHIBITION
8 0.0000081405 SITE OF METABOLISM//ACTIVE SITE TOPOLOGY//COMPUTAT CHEM MOL STRUCT
9 0.0000080813 ANALYT BIOCHEM MASS SPE OMETRY CORE IL//CHIM INTERDISCIPLINARITE SYNTH ANAL MODELISAT//EC MS
10 0.0000075597 DRUG INDUCED LIVER INJURY//HERB INDUCED LIVER INJURY//HYS LAW