Class information for:
Level 1: GLUCOKINASE ACTIVATOR//GLUCOKINASE//GLUCOKINASE REGULATORY PROTEIN

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
13565 763 37.5 71%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
249 19337 ISLET TRANSPLANTATION//PANCREATIC ISLETS//ISLET

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 GLUCOKINASE ACTIVATOR Author keyword 106 91% 6% 43
2 GLUCOKINASE Author keyword 53 28% 21% 160
3 GLUCOKINASE REGULATORY PROTEIN Author keyword 36 77% 3% 24
4 GLUCOKINASE ACTIVATORS Author keyword 31 76% 3% 22
5 THER EUT DISCOVERY MED CHEM Address 11 100% 1% 6
6 LIVER GLUCOKINASE Author keyword 7 67% 1% 6
7 GLUCOKINASE REGULATORY PROTEIN GKRP Author keyword 6 100% 1% 4
8 THER EUT DISCOVERY MOL STRUCT CHARACTERIZ Address 6 100% 1% 4
9 GKA Author keyword 3 100% 0% 3
10 KINETIC COOPERATIVITY Author keyword 3 45% 1% 5

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 GLUCOKINASE ACTIVATOR 106 91% 6% 43 Search GLUCOKINASE+ACTIVATOR Search GLUCOKINASE+ACTIVATOR
2 GLUCOKINASE 53 28% 21% 160 Search GLUCOKINASE Search GLUCOKINASE
3 GLUCOKINASE REGULATORY PROTEIN 36 77% 3% 24 Search GLUCOKINASE+REGULATORY+PROTEIN Search GLUCOKINASE+REGULATORY+PROTEIN
4 GLUCOKINASE ACTIVATORS 31 76% 3% 22 Search GLUCOKINASE+ACTIVATORS Search GLUCOKINASE+ACTIVATORS
5 LIVER GLUCOKINASE 7 67% 1% 6 Search LIVER+GLUCOKINASE Search LIVER+GLUCOKINASE
6 GLUCOKINASE REGULATORY PROTEIN GKRP 6 100% 1% 4 Search GLUCOKINASE+REGULATORY+PROTEIN+GKRP Search GLUCOKINASE+REGULATORY+PROTEIN+GKRP
7 GKA 3 100% 0% 3 Search GKA Search GKA
8 KINETIC COOPERATIVITY 3 45% 1% 5 Search KINETIC+COOPERATIVITY Search KINETIC+COOPERATIVITY
9 GLUCOKINASE ACTIVATOR GKA 2 67% 0% 2 Search GLUCOKINASE+ACTIVATOR+GKA Search GLUCOKINASE+ACTIVATOR+GKA
10 FRUCTOSE 1 PHOSPHATE 1 38% 0% 3 Search FRUCTOSE+1+PHOSPHATE Search FRUCTOSE+1+PHOSPHATE

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DIABETES THERAPY 94 71% 10% 75
2 LIVER GLUCOKINASE 94 71% 10% 75
3 HEPATIC GLUCOKINASE 47 68% 5% 41
4 RAT LIVER GLUCOKINASE 40 79% 3% 26
5 BETA CELL GLUCOKINASE 31 50% 6% 45
6 HEXOKINASE D GLUCOKINASE 30 100% 2% 12
7 FRUCTOSE 1 PHOSPHATE 27 74% 3% 20
8 MAMMALIAN GLUCOKINASE 14 43% 3% 25
9 HEXOKINASE I 13 41% 3% 24
10 SLOW TRANSITION 11 65% 1% 11

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Molecular targeting of the GK-GKRP pathway in diabetes 2015 1 81 48%
Assessing the potential of glucokinase activators in diabetes therapy 2009 169 99 59%
Novel glucokinase activators: a patent review (2008-2010) 2011 27 8 100%
A patent review of glucokinase activators and disruptors of the glucokinase - glucokinase regulatory protein interaction: 2011-2014 2014 6 43 84%
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying? 2013 24 69 54%
Molecular Physiology of Mammalian Glucokinase 2009 108 127 53%
Strategies for the design of hepatoselective glucokinase activators to treat type 2 diabetes 2013 14 45 62%
A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status 2014 7 58 47%
Liver Glucokinase: An Overview on the Regulatory Mechanisms of its Activity 2011 23 45 64%
Recent Updates on Glucokinase Activators for the Treatment of Type 2 Diabetes Mellitus 2014 3 78 77%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 THER EUT DISCOVERY MED CHEM 11 100% 0.8% 6
2 THER EUT DISCOVERY MOL STRUCT CHARACTERIZ 6 100% 0.5% 4
3 DIABET OBES DRUG DISCOVERY 2 50% 0.4% 3
4 CARDIOVASC GASTROINTESTINAL AREA 1 38% 0.4% 3
5 BIOPHARMACEUT COORDINAT 1 100% 0.3% 2
6 DITTMER CHEM 217 1 50% 0.3% 2
7 CARDIOVASC GASTROINTESTINAL INNOVAT MED 1 33% 0.4% 3
8 CARDIOVASC GASTROINTESTINAL 1 30% 0.4% 3
9 BANYU TSUKUBA 1 10% 1.3% 10
10 CENEXA EXPT PL ENDOCRINOL 1 40% 0.3% 2

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000197445 MODY//MATURITY ONSET DIABETES OF THE YOUNG//MATURITY ONSET DIABETES OF THE YOUNG MODY
2 0.0000176682 D GLUCOSE METABOLISM//SUCCINIC ACID DIMETHYL ESTER//EXPT HORMONOL
3 0.0000151176 INSULIN GENE THERAPY//DIABETES GENE THERAPY//ENDOCRINOL METAB SECT 111
4 0.0000135427 VDAC//MITOCHONDRIAL PORIN//VOLTAGE DEPENDENT ANION SELECTIVE CHANNEL
5 0.0000094741 CHILDRENS DIABET//GLUCOLIPOTOXICITY//BETA CELL BIOCHEM
6 0.0000091217 GLUCONEOGENESIS//GLYCOGENOLYSIS//ENDOGENOUS GLUCOSE PRODUCTION
7 0.0000083314 CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN CHREBP//CHREBP//L TYPE PYRUVATE KINASE
8 0.0000066734 CONGENITAL HYPERINSULINISM//NESIDIOBLASTOSIS//HYPERINSULINISM
9 0.0000065989 6 PHOSPHOFRUCTO 2 KINASE//6 PHOSPHOFRUCTO 2 KINASE FRUCTOSE 2 6 BISPHOSPHATASE//FRUCTOSE 2 6 BISPHOSPHATE
10 0.0000064108 PHOSPHOENOLPYRUVATE CARBOXYKINASE//GLYCERONEOGENESIS//PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE