Class information for:
Level 1: HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
16698 575 30.6 68%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1587 6631 FOLATE RECEPTOR//REDUCED FOLATE CARRIER//DIHYDROFOLATE REDUCTASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 HPPK Author keyword 18 83% 2% 10
2 DIHYDROPTEROATE SYNTHASE Author keyword 6 28% 3% 17
3 PYROPHOSPHOKINASE Author keyword 5 63% 1% 5
4 EPIROPRIM Author keyword 4 75% 1% 3
5 DIHYDRONEOPTERIN ALDOLASE Author keyword 3 60% 1% 3
6 DHFR Author keyword 2 10% 4% 21
7 6 HYDROXYMETHYL 7 8 DIHYDROPTERIN PYROPHOSPHOKINASE Author keyword 2 67% 0% 2
8 BACTERIOL MYCOL UNIT Address 2 67% 0% 2
9 HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE Author keyword 2 67% 0% 2
10 ANTIFOLATE Author keyword 2 10% 3% 19

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 HPPK 18 83% 2% 10 Search HPPK Search HPPK
2 DIHYDROPTEROATE SYNTHASE 6 28% 3% 17 Search DIHYDROPTEROATE+SYNTHASE Search DIHYDROPTEROATE+SYNTHASE
3 PYROPHOSPHOKINASE 5 63% 1% 5 Search PYROPHOSPHOKINASE Search PYROPHOSPHOKINASE
4 EPIROPRIM 4 75% 1% 3 Search EPIROPRIM Search EPIROPRIM
5 DIHYDRONEOPTERIN ALDOLASE 3 60% 1% 3 Search DIHYDRONEOPTERIN+ALDOLASE Search DIHYDRONEOPTERIN+ALDOLASE
6 DHFR 2 10% 4% 21 Search DHFR Search DHFR
7 6 HYDROXYMETHYL 7 8 DIHYDROPTERIN PYROPHOSPHOKINASE 2 67% 0% 2 Search 6+HYDROXYMETHYL+7+8+DIHYDROPTERIN+PYROPHOSPHOKINASE Search 6+HYDROXYMETHYL+7+8+DIHYDROPTERIN+PYROPHOSPHOKINASE
8 HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE 2 67% 0% 2 Search HYDROXYMETHYLDIHYDROPTERIN+PYROPHOSPHOKINASE Search HYDROXYMETHYLDIHYDROPTERIN+PYROPHOSPHOKINASE
9 ANTIFOLATE 2 10% 3% 19 Search ANTIFOLATE Search ANTIFOLATE
10 2 4 DIAMINOPYRIMIDINE 2 50% 1% 3 Search 2+4+DIAMINOPYRIMIDINE Search 2+4+DIAMINOPYRIMIDINE

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 POTENTIAL ANTIPNEUMOCYSTIS 60 100% 3% 20
2 ANTITOXOPLASMA 45 94% 3% 16
3 PIRITREXIM 40 82% 4% 23
4 ARGININE RESIDUE 82 33 100% 2% 13
5 ANTIPNEUMOCYSTIS 24 82% 2% 14
6 LIPID SOLUBLE ANTIFOLATE 18 59% 3% 20
7 7 8 DIHYDRO 6 HYDROXYMETHYLPTERIN PYROPHOSPHOKINASE 17 100% 1% 8
8 7 8 DIHYDRONEOPTERIN ALDOLASE 17 100% 1% 8
9 COLI 6 HYDROXYMETHYL 7 8 DIHYDROPTERIN PYROPHOSPHOKINASE 15 82% 2% 9
10 HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE 15 48% 4% 23

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Antifolate agents: a patent review (2006-2010) 2011 7 32 69%
DNA and RNA synthesis: Antifolates 2005 100 219 32%
Towards species-specific antifolates 2006 42 150 50%
The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery 2002 82 58 36%
THE STRUCTURE AND MECHANISM OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE 2008 9 51 63%
Dihydrofolate reductase as a target for chemotherapy in parasites 2007 33 154 40%
A Review of Molecular Modelling Studies of Dihydrofolate Reductase Inhibitors Against Opportunistic Microorganisms and Comprehensive Evaluation of New Models 2011 2 97 68%
Replacing sulfa drugs with novel DHPS inhibitors 2013 1 36 53%
Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges 2012 8 124 29%
Targeting DHFR in parasitic protozoa 2005 65 47 21%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 BACTERIOL MYCOL UNIT 2 67% 0.3% 2
2 ALTHOUSE 8B 1 50% 0.2% 1
3 CNRSURA 1287 1 50% 0.2% 1
4 PHYS SCI 107 1 50% 0.2% 1
5 SERV MALAD INFECT TROP INFECT DIS 1 50% 0.2% 1
6 UMR 6236IRD 198IFR 48 MED 1 50% 0.2% 1
7 HAMMERSMITH MED LTD 0 33% 0.2% 1
8 HOSP UNIV POLMIT 0 33% 0.2% 1
9 MOL PATHOL TB 0 33% 0.2% 1
10 UNIT HIGHLY PATHOGEN BACTERIA 0 33% 0.2% 1

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000232022 DIHYDROFOLATE REDUCTASE//HYDROGEN TUNNELING//PROMOTING VIBRATION
2 0.0000162686 REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//HEREDITARY FOLATE MALABSORPTION
3 0.0000115667 PYRIDO2 3 DPYRIMIDINE//PYRANO4 3 DPYRIMIDINIUM SALTS//PYRIDO4 3 DPYRIMIDINIUM SALTS
4 0.0000115190 ATOVAQUONE//TOXOPLASMIC ENCEPHALITIS//TOXOPLASMA ENCEPHALITIS
5 0.0000115120 SPHEROIDAL GRANULE//DIHYDROPTEROATE SYNTHASE INHIBITOR//DRUG INDUCED DELIRIUM
6 0.0000086027 PNEUMOCYSTIS JIROVECII//PNEUMOCYSTIS CARINII//PNEUMOCYSTIS PNEUMONIA
7 0.0000079050 THYMIDYLATE SYNTHASE//THYX//DEOXYTUBULOSINE
8 0.0000047631 DIPHENYLBORON CHELATES//DIFLUOROBORON CHELATES//AROYLACETONITRILES
9 0.0000046472 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//JCSG//PROGRAM BIOINFORMAT SYST BIOL
10 0.0000044891 SHARPLESS CONDITIONS//FLUOROORGAN//3H PYRIMIDIN 4 ONE