Class information for:
Level 1: PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
4336 1729 51.1 91%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
395 16247 CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PREGNANE X RECEPTOR Author keyword 208 68% 10% 181
2 PXR Author keyword 143 59% 9% 161
3 CONSTITUTIVE ANDROSTANE RECEPTOR Author keyword 139 75% 6% 101
4 PHARMACOGENET SECT Address 43 38% 5% 90
5 PREGNANE X RECEPTOR PXR Author keyword 26 69% 1% 22
6 HPXR Author keyword 20 100% 1% 9
7 CONSTITUTIVE ANDROSTANE RECEPTOR CAR Author keyword 19 68% 1% 17
8 REPROD DEV TOXICOL Address 16 16% 5% 93
9 CAR Author keyword 16 15% 6% 99
10 NR1I3 Author keyword 11 78% 0% 7

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 PREGNANE X RECEPTOR 208 68% 10% 181 Search PREGNANE+X+RECEPTOR Search PREGNANE+X+RECEPTOR
2 PXR 143 59% 9% 161 Search PXR Search PXR
3 CONSTITUTIVE ANDROSTANE RECEPTOR 139 75% 6% 101 Search CONSTITUTIVE+ANDROSTANE+RECEPTOR Search CONSTITUTIVE+ANDROSTANE+RECEPTOR
4 PREGNANE X RECEPTOR PXR 26 69% 1% 22 Search PREGNANE+X+RECEPTOR+PXR Search PREGNANE+X+RECEPTOR+PXR
5 HPXR 20 100% 1% 9 Search HPXR Search HPXR
6 CONSTITUTIVE ANDROSTANE RECEPTOR CAR 19 68% 1% 17 Search CONSTITUTIVE+ANDROSTANE+RECEPTOR+CAR Search CONSTITUTIVE+ANDROSTANE+RECEPTOR+CAR
7 CAR 16 15% 6% 99 Search CAR Search CAR
8 NR1I3 11 78% 0% 7 Search NR1I3 Search NR1I3
9 XENOBIOTIC RECEPTOR 9 67% 0% 8 Search XENOBIOTIC+RECEPTOR Search XENOBIOTIC+RECEPTOR
10 CYP2B 9 29% 1% 25 Search CYP2B Search CYP2B

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CONSTITUTIVE ANDROSTANE RECEPTOR 334 46% 31% 541
2 PREGNANE X RECEPTOR 287 35% 38% 658
3 XENOBIOTIC RECEPTOR 266 81% 9% 158
4 PXR 225 69% 11% 190
5 ENHANCER MODULE 162 80% 6% 99
6 CYP3A4 GENE EXPRESSION 128 87% 4% 62
7 RESPONSIVE ENHANCER MODULE 102 85% 3% 53
8 CYP2B GENE 93 80% 3% 57
9 DISTAL ENHANCER MODULE 73 85% 2% 39
10 XENOBIOTIC RESPONSE 70 78% 3% 46

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond 2013 23 134 72%
Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator 2014 17 104 31%
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters 2012 55 255 51%
Targeting xenobiotic receptors PXR and CAR in human diseases 2015 1 95 82%
Signaling control of the constitutive androstane receptor (CAR) 2014 4 92 85%
Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR 2010 71 172 66%
Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects 2009 104 289 60%
Deciphering the roles of the constitutive androstane receptor in energy metabolism 2015 1 111 68%
Targeting xenobiotic receptors PXR and CAR for metabolic diseases 2012 26 71 73%
Role of CAR and PXR in xenobiotic sensing and metabolism 2012 23 129 78%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PHARMACOGENET SECT 43 38% 5.2% 90
2 REPROD DEV TOXICOL 16 16% 5.4% 93
3 NUCL RECEPTOR DISCOVERY 7 32% 1.0% 18
4 PL PHARMACEUT EDUC 5 55% 0.3% 6
5 DRUG METAB MOL TOXICOL 4 16% 1.3% 23
6 PHARMACOL NEUROBIOL 3 13% 1.3% 22
7 U632 3 21% 0.8% 13
8 BIOSCI SUPPORT 3 60% 0.2% 3
9 UNIDAD HEPATOL EXPT 3 13% 1.0% 18
10 PHARMACODYNAM MOL GENET 2 32% 0.3% 6

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000207491 PHARMACOEPIGENETICS//ALFRED MED EDUC PROJECT//BANDUNG HOSP
2 0.0000123278 PHARMACOKINET BIOANAL//CYP2D19//PROPRANOLOL ENANTIOMER
3 0.0000116203 CYP3A//COCKTAIL//MECHANISM BASED INHIBITION
4 0.0000106798 CYP2C12//ONE DAY TREATMENT//S BIOCHEM
5 0.0000085002 FARNESOID X RECEPTOR//FXR//TGR5
6 0.0000074232 ROLLINS 5119//ANTIPYRINE PHARMACOKINETICS//CYTOCHROME P4502B1 2
7 0.0000072847 CONAZOLES//ZEBRAFISH EMBRYOTOXICITY TEST//TRIADIMEFON
8 0.0000066843 EFAVIRENZ//CYP2B6//NEVIRAPINE
9 0.0000064566 CYP1B1//CYP2S1//CYTOCHROME P4501B1
10 0.0000061929 CYTOKINE BIOL SIGNAL TRANSDUCT//MICROGLIAL INFLAMMATION//MOUTH CLEANING