Class information for:
Level 1: CATECHOL O METHYLTRANSFERASE//COMT//TOLCAPONE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
5277 1579 42.6 77%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
613 13260 5 HTTLPR//CATECHOL O METHYLTRANSFERASE//COMT

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CATECHOL O METHYLTRANSFERASE Author keyword 186 51% 17% 263
2 COMT Author keyword 156 41% 19% 293
3 TOLCAPONE Author keyword 113 71% 6% 92
4 ENTACAPONE Author keyword 39 38% 5% 82
5 COMT INHIBITION Author keyword 34 65% 2% 32
6 CATECHOL O METHYLTRANSFERASE COMT Author keyword 30 56% 2% 36
7 COMT INHIBITOR Author keyword 26 67% 2% 24
8 NEBICAPONE Author keyword 24 91% 1% 10
9 COMT VAL158MET Author keyword 20 66% 1% 19
10 COMT INHIBITORS Author keyword 15 49% 1% 23

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 CATECHOL O METHYLTRANSFERASE 186 51% 17% 263 Search CATECHOL+O+METHYLTRANSFERASE Search CATECHOL+O+METHYLTRANSFERASE
2 COMT 156 41% 19% 293 Search COMT Search COMT
3 TOLCAPONE 113 71% 6% 92 Search TOLCAPONE Search TOLCAPONE
4 ENTACAPONE 39 38% 5% 82 Search ENTACAPONE Search ENTACAPONE
5 COMT INHIBITION 34 65% 2% 32 Search COMT+INHIBITION Search COMT+INHIBITION
6 CATECHOL O METHYLTRANSFERASE COMT 30 56% 2% 36 Search CATECHOL+O+METHYLTRANSFERASE+COMT Search CATECHOL+O+METHYLTRANSFERASE+COMT
7 COMT INHIBITOR 26 67% 2% 24 Search COMT+INHIBITOR Search COMT+INHIBITOR
8 NEBICAPONE 24 91% 1% 10 Search NEBICAPONE Search NEBICAPONE
9 COMT VAL158MET 20 66% 1% 19 Search COMT+VAL158MET Search COMT+VAL158MET
10 COMT INHIBITORS 15 49% 1% 23 Search COMT+INHIBITORS Search COMT+INHIBITORS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CATECHOL O METHYLTRANSFERASE 126 23% 30% 472
2 COMT 87 45% 9% 144
3 INHIBITOR TOLCAPONE 80 100% 2% 25
4 TOLCAPONE 75 61% 5% 79
5 SELECTIVE COMT INHIBITORS 73 88% 2% 35
6 VAL158MET POLYMORPHISM 62 55% 5% 77
7 VAL108 158 MET GENOTYPE 59 58% 4% 67
8 METHYL TRANSFERASE 56 47% 6% 88
9 COMT INHIBITORS 53 69% 3% 46
10 VAL158MET GENOTYPE 44 54% 4% 56

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Effects of COMT polymorphisms on brain function and behavior in health and disease 2012 36 134 74%
Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors 1999 554 292 61%
Catechol-o-methyltransferase, cognition, and psychosis: Val(158)Met and beyond 2006 325 96 61%
GENES, COGNITION AND BRAIN THROUGH A COMT LENS 2009 74 117 53%
Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission 2014 7 225 33%
Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease 2000 87 73 70%
THE CATECHOL O-METHYLTRANSFERASE GENE ITS REGULATION AND POLYMORPHISMS 2010 27 86 67%
Role of the COMT gene Va1158Met polymorphism in mental disorders: A review 2007 73 54 69%
Intermediate phenotypes and genetic mechanisms of psychiatric disorders 2006 470 87 22%
Inverted-U-Shaped Dopamine Actions on Human Working Memory and Cognitive Control 2011 230 141 9%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 INVEST DESENVOLVIMENTO 5 54% 0.4% 7
2 UNIT DYNAM IMAGING GENET 4 75% 0.2% 3
3 GENES COGNIT PSYCHOSIS PROGRAM 4 13% 1.6% 26
4 PSYCHIAT NEUROSCI GRP 3 26% 0.6% 10
5 SECT MENTAL DISORDERS 2 36% 0.3% 5
6 PRAKLIN FOR 2 30% 0.4% 6
7 CIC 1422 1 50% 0.1% 2
8 ORION 1 27% 0.3% 4
9 NEUROL AGEING DEGENERAT CEREBROVASC DIS 1 21% 0.3% 4
10 MED BIOCHEM MED BIOL 1 25% 0.2% 3

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000109290 MAOA//MONOAMINE OXIDASE A//MAOA GENE
2 0.0000091639 MOTOR FLUCTUATIONS//LEVODOPA//DYSKINESIA
3 0.0000085676 DRD4//DAT1//DOPAMINE TRANSPORTER GENE
4 0.0000085513 DRD2//REWARD DEFICIENCY SYNDROME RDS//D2 DOPAMINE RECEPTOR GENE
5 0.0000077547 DELAY PERIOD ACTIVITY//CORT CIRCUITS COMPUTAT//HIGH TECH CHIYODA KU
6 0.0000077452 OPRM1//A118G//OPRM1 GENE
7 0.0000064561 DRD3//T102C POLYMORPHISM//TARDIVE DYSKINESIA
8 0.0000064502 ACETYLENIC AMINO ACID//MULTISUBSTRATE INHIBITOR//COENZYME MODEL
9 0.0000060427 5 HTTLPR//SEROTONIN TRANSPORTER GENE//SEROTONIN TRANSPORTER
10 0.0000055838 NEPICASTAT//COCAINE INDUCED PSYCHOSIS//DOPAMINE BETA HYDROXYLASE