Class information for:
Level 1: SYNTHET BIOORGAN CHEM//NUCLE ACID//NUCL ACID

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
5552 1542 35.0 78%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
77 26633 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//NUCLEOSIDES & NUCLEOTIDES//NUCLEOSIDES

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 SYNTHET BIOORGAN CHEM Address 76 93% 2% 28
2 NUCLE ACID Address 30 32% 5% 77
3 NUCL ACID Address 16 33% 3% 40
4 ALPHA L LNA Author keyword 10 73% 1% 8
5 LOCKED NUCLEIC ACID Author keyword 8 27% 2% 27
6 BNA Author keyword 8 60% 1% 9
7 BRIDGED NUCLEIC ACIDS Author keyword 7 67% 0% 6
8 NUCLEIC ACID Address 6 45% 1% 10
9 BICYCLO DNA Author keyword 6 100% 0% 4
10 BRIDGED NUCLEIC ACID Author keyword 6 100% 0% 4

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 ALPHA L LNA 10 73% 1% 8 Search ALPHA+L+LNA Search ALPHA+L+LNA
2 LOCKED NUCLEIC ACID 8 27% 2% 27 Search LOCKED+NUCLEIC+ACID Search LOCKED+NUCLEIC+ACID
3 BNA 8 60% 1% 9 Search BNA Search BNA
4 BRIDGED NUCLEIC ACIDS 7 67% 0% 6 Search BRIDGED+NUCLEIC+ACIDS Search BRIDGED+NUCLEIC+ACIDS
5 BICYCLO DNA 6 100% 0% 4 Search BICYCLO+DNA Search BICYCLO+DNA
6 BRIDGED NUCLEIC ACID 6 100% 0% 4 Search BRIDGED+NUCLEIC+ACID Search BRIDGED+NUCLEIC+ACID
7 TRICYCLO DNA 6 100% 0% 4 Search TRICYCLO+DNA Search TRICYCLO+DNA
8 CONFORMATIONAL RESTRICTION 5 20% 1% 21 Search CONFORMATIONAL+RESTRICTION Search CONFORMATIONAL+RESTRICTION
9 ANTISENSE AGENTS 5 25% 1% 16 Search ANTISENSE+AGENTS Search ANTISENSE+AGENTS
10 OLIGONUCLEOTIDE ANALOGS 4 67% 0% 4 Search OLIGONUCLEOTIDE+ANALOGS Search OLIGONUCLEOTIDE+ANALOGS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 NUCLEIC ACID ANALOGS 81 74% 4% 60
2 BACKBONE BICYCLO DNA 62 90% 2% 27
3 CONSTRAINT CONFORMATIONAL FLEXIBILITY 62 90% 2% 27
4 EXONUCLEASE RESISTANCE 53 89% 2% 24
5 THYMIDINE DIMERS 44 100% 1% 16
6 BICYCLO DNA 44 88% 1% 21
7 TRICYCLO DNA 44 81% 2% 26
8 BASE PAIRING PROPERTIES 41 45% 4% 68
9 ALPHA L LNA 36 66% 2% 33
10 LOCKED NUCLEIC ACID 35 34% 6% 85

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
LNA: a versatile tool for therapeutics and genomics 2003 349 54 63%
The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes 1997 472 105 50%
Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA) 2007 132 149 52%
Synthesis of 3 '-C- and 4 '-C-branched oligodeoxynucleotides and the development of locked nucleic acid (LNA) 1999 246 50 66%
An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics 2011 46 93 66%
Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals 2011 46 76 54%
Antisense technologies - Improvement through novel chemical modifications 2003 656 118 17%
2 '-modified oligonucleotides for antisense therapeutics 2007 56 48 63%
DNA analogues: From supramolecular principles to biological properties 2002 175 98 51%
Bicyclic nucleosides and conformational restriction of oligonucleotides 2000 81 69 78%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 SYNTHET BIOORGAN CHEM 76 93% 1.8% 28
2 NUCLE ACID 30 32% 5.0% 77
3 NUCL ACID 16 33% 2.6% 40
4 NUCLEIC ACID 6 45% 0.6% 10
5 SYNTH BIOORGAN CHEM 4 75% 0.2% 3
6 SYNTHET BIORGAN CHEM 3 100% 0.2% 3
7 SYNTH PHYS CHIM MOL INTERET BIOL 2 26% 0.5% 8
8 MED CHEM ANTISENSE CORE 2 67% 0.1% 2
9 SERV COMMUN RMN 2 17% 0.6% 9
10 TECHNOL GROWTH 1 100% 0.1% 2

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000248522 L DNA//HETEROCHIRAL DNA//UMR CNRS UMII 5625
2 0.0000215916 KETONUCLEOSIDES//UNSATURATED NUCLEOSIDES//EXOMETHYLENE NUCLEOSIDES
3 0.0000155481 TAS 106//ORGANOSILICON REAGENT//ORGANOALUMINUM REAGENT
4 0.0000149784 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT//ANTISENSE RESEARCH AND DEVELOPMENT//ANTISENSE
5 0.0000135021 PHOSPHOROTHIOLATE//P 32ORTHOPHOSPHORIC ACID//SYNTHESIS OF P 32 LABELED NUCLEOTIDES
6 0.0000133167 OLIGONUCLEOTIDE PEPTIDE CONJUGATE//PEPTIDE OLIGONUCLEOTIDE CONJUGATE//OLIGONUCLEOTIDE PEPTIDE CONJUGATES
7 0.0000123766 PEPTIDE NUCLEIC ACIDS//PEPTIDE NUCLEIC ACID//PNA
8 0.0000117858 H PHOSPHONATES//OLIGONUCLEOTIDE SYNTHESIS//UNIVERSAL SOLID SUPPORT
9 0.0000116196 EXON SKIPPING//DMD GENET THER Y GRP//MC LOCKWOOD MUSCULAR DYSTROPHY
10 0.0000110091 PROGRAM BIOCHEM CHEM//RNA CRYSTALLOGRAPHY//5 METHYL CYTIDINE