Class information for:
Level 1: CYP3A//COCKTAIL//MECHANISM BASED INHIBITION

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
6192 1453 44.4 85%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
395 16247 CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CYP3A Author keyword 11 14% 5% 76
2 COCKTAIL Author keyword 10 34% 2% 24
3 MECHANISM BASED INHIBITION Author keyword 10 31% 2% 26
4 CYP INHIBITION Author keyword 7 34% 1% 18
5 4 BETA HYDROXYCHOLESTEROL Author keyword 6 48% 1% 10
6 INHIBITORY MONOCLONAL ANTIBODIES Author keyword 6 80% 0% 4
7 AREA UNDER THE CONCENTRATION CURVE RATIO AUCR Author keyword 6 100% 0% 4
8 IDMOC Author keyword 6 100% 0% 4
9 MECHANISM BASED INACTIVATION Author keyword 5 26% 1% 18
10 HUMAN LIVER MICROSOMES Author keyword 5 13% 3% 38

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 CYP3A 11 14% 5% 76 Search CYP3A Search CYP3A
2 COCKTAIL 10 34% 2% 24 Search COCKTAIL Search COCKTAIL
3 MECHANISM BASED INHIBITION 10 31% 2% 26 Search MECHANISM+BASED+INHIBITION Search MECHANISM+BASED+INHIBITION
4 CYP INHIBITION 7 34% 1% 18 Search CYP+INHIBITION Search CYP+INHIBITION
5 4 BETA HYDROXYCHOLESTEROL 6 48% 1% 10 Search 4+BETA+HYDROXYCHOLESTEROL Search 4+BETA+HYDROXYCHOLESTEROL
6 INHIBITORY MONOCLONAL ANTIBODIES 6 80% 0% 4 Search INHIBITORY+MONOCLONAL+ANTIBODIES Search INHIBITORY+MONOCLONAL+ANTIBODIES
7 AREA UNDER THE CONCENTRATION CURVE RATIO AUCR 6 100% 0% 4 Search AREA+UNDER+THE+CONCENTRATION+CURVE+RATIO+AUCR Search AREA+UNDER+THE+CONCENTRATION+CURVE+RATIO+AUCR
8 IDMOC 6 100% 0% 4 Search IDMOC Search IDMOC
9 MECHANISM BASED INACTIVATION 5 26% 1% 18 Search MECHANISM+BASED+INACTIVATION Search MECHANISM+BASED+INACTIVATION
10 HUMAN LIVER MICROSOMES 5 13% 3% 38 Search HUMAN+LIVER+MICROSOMES Search HUMAN+LIVER+MICROSOMES

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 INTERMEDIATE COMPLEX FORMATION 50 71% 3% 40
2 CYTOCHROME P450 3A ACTIVITY 28 50% 3% 41
3 DRUG DRUG INTERACTIONS 21 14% 10% 145
4 ERYTHROMYCIN BREATH TEST 20 28% 4% 63
5 SYSTEMIC ANTIMYCOTICS KETOCONAZOLE 19 39% 3% 37
6 IN VIVO INTERACTION 18 83% 1% 10
7 5 DRUG COCKTAIL 18 89% 1% 8
8 IN VITRO DATA 16 24% 4% 57
9 COMBINED PHENOTYPIC ASSESSMENT 15 68% 1% 13
10 IN VITRO COCKTAIL 15 77% 1% 10

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Dealing with the complex drug-drug interactions: Towards mechanistic models 2015 3 125 32%
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4 2008 215 143 34%
4 beta-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans 2011 34 26 54%
Validated assays for human cytochrome P450 activities 2004 237 112 39%
Predicting in vivo drug interactions from in vitro drug discovery data 2005 296 94 32%
Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug-drug interaction prediction methods 2009 46 66 56%
Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity 2011 38 180 33%
The Current Status of Time Dependent CYP Inhibition Assay and In Silico Drug-drug Interaction Predictions 2012 6 37 84%
Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development 2011 16 94 61%
In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: Current status on methodologies and their utility for predicting drug-drug interactions 2008 43 57 65%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 METAB CHEM 4 46% 0.4% 6
2 POST MKT PROD DEV 3 100% 0.2% 3
3 PHYS METAB SCI 2 17% 0.9% 13
4 BIOPHARMACEUT PHARMACOKINET S 2 21% 0.7% 10
5 ELED CPD SYNTH 2 67% 0.1% 2
6 SIMCYP LTD 2 67% 0.1% 2
7 BLADES ENTERPRISE 2 14% 0.9% 13
8 GLOBAL DRUG METAB PHARMACOKINET 2 43% 0.2% 3
9 WISHARD MEM HOSP 1 15% 0.6% 9
10 PHARMACOKINET PHARMACOGENET GRP 1 38% 0.2% 3

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000272528 PHARMACOKINET BIOANAL//CYP2D19//PROPRANOLOL ENANTIOMER
2 0.0000209519 SITE OF METABOLISM//ACTIVE SITE TOPOLOGY//COMPUTAT CHEM MOL STRUCT
3 0.0000185644 GRAPEFRUIT JUICE//HERB DRUG INTERACTIONS//BERGAMOTTIN
4 0.0000185594 INTERSPECIES SCALING//DMPK TRANSLAT SCI//WELL STIRRED MODEL
5 0.0000146342 CYP1A2//CAFFEINE METABOLISM//CYP1A2 ACTIVITY
6 0.0000133308 CYP3A5//TACROLIMUS//CYTOCHROME P450 3A5
7 0.0000128263 OATP1B1//SLCO1B1//OATP
8 0.0000126941 CYP2D6//DEBRISOQUINE//CYP2C19
9 0.0000116203 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR
10 0.0000090870 CACO 2//SINGLE PASS INTESTINAL PERFUSION//INTESTINAL PERFUSION