Class information for:
Level 1: TOPOISOMERASE II//ICRF 193//DNA TOPOISOMERASE II

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
705 3079 43.5 83%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
540 13989 FLUOROQUINOLONES//CIPROFLOXACIN//QUINOLONES

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 TOPOISOMERASE II Author keyword 88 33% 7% 222
2 ICRF 193 Author keyword 47 81% 1% 29
3 DNA TOPOISOMERASE II Author keyword 42 47% 2% 67
4 HUMAN TOPOISOMERASE I Author keyword 42 94% 0% 15
5 DNA TOPOISOMERASE I Author keyword 37 43% 2% 67
6 TOPOISOMERASE I Author keyword 35 24% 4% 127
7 TOPOISOMERASE II BETA Author keyword 27 70% 1% 23
8 TOPOISOMERASE II ALPHA Author keyword 26 31% 2% 71
9 TOPOISOMERASE Author keyword 26 20% 4% 114
10 F 11782 Author keyword 20 100% 0% 9

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 TOPOISOMERASE II 88 33% 7% 222 Search TOPOISOMERASE+II Search TOPOISOMERASE+II
2 ICRF 193 47 81% 1% 29 Search ICRF+193 Search ICRF+193
3 DNA TOPOISOMERASE II 42 47% 2% 67 Search DNA+TOPOISOMERASE+II Search DNA+TOPOISOMERASE+II
4 HUMAN TOPOISOMERASE I 42 94% 0% 15 Search HUMAN+TOPOISOMERASE+I Search HUMAN+TOPOISOMERASE+I
5 DNA TOPOISOMERASE I 37 43% 2% 67 Search DNA+TOPOISOMERASE+I Search DNA+TOPOISOMERASE+I
6 TOPOISOMERASE I 35 24% 4% 127 Search TOPOISOMERASE+I Search TOPOISOMERASE+I
7 TOPOISOMERASE II BETA 27 70% 1% 23 Search TOPOISOMERASE+II+BETA Search TOPOISOMERASE+II+BETA
8 TOPOISOMERASE II ALPHA 26 31% 2% 71 Search TOPOISOMERASE+II+ALPHA Search TOPOISOMERASE+II+ALPHA
9 TOPOISOMERASE 26 20% 4% 114 Search TOPOISOMERASE Search TOPOISOMERASE
10 F 11782 20 100% 0% 9 Search F+11782 Search F+11782

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DNA TOPOISOMERASE 106 44% 6% 183
2 EUKARYOTIC TOPOISOMERASE 105 65% 3% 100
3 ANTITUMOR DRUGS 100 35% 8% 236
4 DNA TOPOISOMERASES 87 33% 7% 218
5 BIS2 6 DIOXOPIPERAZINE DERIVATIVES 84 68% 2% 73
6 ACTIVE SITE TYROSINE 53 70% 1% 44
7 CAMPTOTHECIN RESISTANCE 52 72% 1% 41
8 CAMPTOTHECIN 51 15% 10% 318
9 TARGETED DRUGS 47 66% 1% 43
10 CATALYTIC INHIBITORS 37 74% 1% 28

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
DNA topoisomerases 1996 1684 496 58%
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs 2010 305 105 51%
Drugging Topoisomerases: Lessons and Challenges 2013 96 137 45%
DNA topoisomerases: Structure, function, and mechanism 2001 1280 184 34%
Targeting DNA topoisomerase II in cancer chemotherapy 2009 354 156 48%
Cellular roles of DNA topoisomerases: A molecular perspective 2002 1137 111 28%
Topoisomerase I inhibitors: camptothecins and beyond 2006 648 140 35%
Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice 2000 212 239 81%
DNA TOPOISOMERASES - ESSENTIAL ENZYMES AND LETHAL TARGETS 1994 602 149 59%
Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme 1998 342 147 90%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 G MORUZZI BIOCHEM 6 50% 0.3% 8
2 INTER ONCOL 4 67% 0.1% 4
3 BIOL PHARMACOL DNA TOPOISOMERASES 3 57% 0.1% 4
4 BIOSTRUCT BIOSYST INBB 3 45% 0.2% 5
5 REG CANC TREATMENT SERV 3 60% 0.1% 3
6 MED MYCOL SHOWA KU 2 36% 0.2% 5
7 CANC TREATMENT MOLEC PHARMACOL 2 67% 0.1% 2
8 EXPT CANCEROL 1 2 67% 0.1% 2
9 BIOSTRUCT GRP 2 21% 0.2% 7
10 MOLEC PHARMACOL 1 13% 0.3% 10

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000200716 DNA GYRASE//GYRASE//REVERSE GYRASE
2 0.0000150330 HEAT SHOCK PROTECTION//ADP RIBOSEPOLYMERASE//CHICKEN EMBRYO CELLS
3 0.0000123116 CAMPTOTHECIN//SN 38//TOPOTECAN
4 0.0000096010 AOA2//ARSACS//APRATAXIN
5 0.0000083846 EQUIPE ACCUEIL EA 3105//ESCHERICHIA COLI WP2UVRA PKM101//DIRECC INVEST ENSENANZA
6 0.0000063598 MERBARONE//SEZ CHIM FARMACO PRODOTTO COSMET//SQUAMOUS CELL CARCINOMA CERVIX
7 0.0000063273 PYRAZOLOACRIDINE//C 1311//IMIDAZOACRIDINONES
8 0.0000058736 ETOPOSIDE PHOSPHATE//ETOPOSIDE//ORAL ETOPOSIDE
9 0.0000056211 BENZOCPHENANTHRIDINE//INDENOISOQUINOLINE//3 ARYLISOQUINOLINE
10 0.0000052642 ELLIPTICINE//OLIVACINE//INTOPLICINE