Class information for:
Level 1: THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYL TRANSFERASE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
7541 1276 38.2 83%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
903 10618 DIHYDROPYRIMIDINE DEHYDROGENASE//5 FLUOROURACIL//THYMIDINE PHOSPHORYLASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 THYMIDYLATE SYNTHASE Author keyword 200 41% 30% 379
2 DIHYDROPYRIMIDINE DEHYDROGENASE Author keyword 47 33% 9% 117
3 OROTATE PHOSPHORIBOSYL TRANSFERASE Author keyword 32 80% 2% 20
4 OROTATE PHOSPHORIBOSYLTRANSFERASE Author keyword 23 56% 2% 28
5 OPRT Author keyword 15 82% 1% 9
6 TS POLYMORPHISM Author keyword 14 100% 1% 7
7 THYMIDYLATE SYNTHASE TS Author keyword 10 52% 1% 13
8 TYMS Author keyword 9 43% 1% 17
9 DIHYDROPYRIMIDINE DEHYDROGENASE DPD Author keyword 9 52% 1% 12
10 TS Author keyword 6 19% 2% 27

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 THYMIDYLATE SYNTHASE 200 41% 30% 379 Search THYMIDYLATE+SYNTHASE Search THYMIDYLATE+SYNTHASE
2 DIHYDROPYRIMIDINE DEHYDROGENASE 47 33% 9% 117 Search DIHYDROPYRIMIDINE+DEHYDROGENASE Search DIHYDROPYRIMIDINE+DEHYDROGENASE
3 OROTATE PHOSPHORIBOSYL TRANSFERASE 32 80% 2% 20 Search OROTATE+PHOSPHORIBOSYL+TRANSFERASE Search OROTATE+PHOSPHORIBOSYL+TRANSFERASE
4 OROTATE PHOSPHORIBOSYLTRANSFERASE 23 56% 2% 28 Search OROTATE+PHOSPHORIBOSYLTRANSFERASE Search OROTATE+PHOSPHORIBOSYLTRANSFERASE
5 OPRT 15 82% 1% 9 Search OPRT Search OPRT
6 TS POLYMORPHISM 14 100% 1% 7 Search TS+POLYMORPHISM Search TS+POLYMORPHISM
7 THYMIDYLATE SYNTHASE TS 10 52% 1% 13 Search THYMIDYLATE+SYNTHASE+TS Search THYMIDYLATE+SYNTHASE+TS
8 TYMS 9 43% 1% 17 Search TYMS Search TYMS
9 DIHYDROPYRIMIDINE DEHYDROGENASE DPD 9 52% 1% 12 Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DPD Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DPD
10 TS 6 19% 2% 27 Search TS Search TS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 FLUOROPYRIMIDINE BASED CHEMOTHERAPY 129 85% 5% 68
2 DIHYDROPYRIMIDINE DEHYDROGENASE 97 33% 19% 240
3 FLUOROURACIL BASED CHEMOTHERAPY 57 55% 6% 72
4 ENHANCER REGION 46 54% 5% 60
5 THYMIDYLATE SYNTHASE EXPRESSION 43 37% 7% 92
6 PROMOTER ENHANCER REGION 38 70% 2% 31
7 THYMIDINE PHOSPHORYLASE 28 18% 11% 146
8 THYMIDYLATE SYNTHASE GENE 27 21% 9% 114
9 THYMIDYLATE SYNTHASE 22 10% 16% 206
10 REPEAT SEQUENCE 21 50% 2% 30

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Thymidylate synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis 2004 278 49 69%
How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy 2015 2 60 40%
Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis 2012 14 55 75%
5-Fluorouracil: Mechanisms of action and clinical strategies 2003 1149 96 21%
5-fluorouracil pharmacogenomics: still rocking after all these years? 2011 18 66 70%
G > C SNP of thymidylate synthase with respect to colorectal cancer 2007 18 45 89%
Current approaches for TYMS polymorphisms and their importance in molecular epidemiology and pharmacogenetics 2013 6 73 56%
Genetic factors influencing pyrimidine-antagonist chemotherapy 2005 65 174 49%
5-fluorouracil: Mechanisms of resistance and reversal strategies 2008 73 100 25%
Predictive Value of Thymidylate Synthase Expression in Gastric Cancer: A Systematic Review with Meta-analysis 2012 6 43 51%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 UNITA CHEMIOTER IA 4 75% 0.2% 3
2 OPTIMAL MED 3 100% 0.2% 3
3 CANC 2 3 37% 0.5% 7
4 BIOMED SCI METAB NEURAL SCI 2 67% 0.2% 2
5 VA CT CANC 2 67% 0.2% 2
6 PL ONCOL 2 29% 0.4% 5
7 CLIN ONCOL MED ONCOL 1 100% 0.2% 2
8 ONCOL MED AFFAIRS 1 50% 0.2% 2
9 THORAC SURG STUDY GRP 1 50% 0.2% 2
10 DANISH COLORECTAL CANC GRP S 1 16% 0.5% 6

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000247314 THYMIDYLATE SYNTHASE//THYX//DEOXYTUBULOSINE
2 0.0000224969 DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY
3 0.0000196585 THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//THYMIDINE PHOSPHORYLASE INHIBITOR
4 0.0000141524 ERCC1//RRM1//MED OVARIAN CANC SECT
5 0.0000115812 BIOCHEMICAL MODULATION//LEUCOVORIN//FOLINIC ACID
6 0.0000108084 OXALIPLATIN//CAPECITABINE//IRINOTECAN
7 0.0000098875 MTHFR//FOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE
8 0.0000097763 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//ALPHA D RIBOSE 1 PHOSPHATE
9 0.0000087739 THYMIDINE KINASE 1//SERUM THYMIDINE KINASE 1//DNA SYNTHESIZING ENZYMES
10 0.0000078899 ADVANCED GASTRIC CANCER//S 1//METASTATIC GASTRIC CANCER