Class information for:
Level 1: DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
7749 1253 29.8 71%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
903 10618 DIHYDROPYRIMIDINE DEHYDROGENASE//5 FLUOROURACIL//THYMIDINE PHOSPHORYLASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DIHYDROPYRIMIDINE DEHYDROGENASE Author keyword 70 39% 11% 139
2 DPYD Author keyword 40 71% 3% 32
3 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY Author keyword 26 87% 1% 13
4 ENILURACIL Author keyword 19 63% 2% 19
5 BETA UREIDOPROPIONASE Author keyword 15 77% 1% 10
6 DPYD GENE Author keyword 14 100% 1% 7
7 DPYS Author keyword 14 100% 1% 7
8 DPD DEFICIENCY Author keyword 12 75% 1% 9
9 DIHYDROURACIL Author keyword 11 57% 1% 13
10 FLUOROPYRIMIDINE DRUGS Author keyword 11 100% 0% 6

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 DIHYDROPYRIMIDINE DEHYDROGENASE 70 39% 11% 139 Search DIHYDROPYRIMIDINE+DEHYDROGENASE Search DIHYDROPYRIMIDINE+DEHYDROGENASE
2 DPYD 40 71% 3% 32 Search DPYD Search DPYD
3 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY 26 87% 1% 13 Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DEFICIENCY Search DIHYDROPYRIMIDINE+DEHYDROGENASE+DEFICIENCY
4 ENILURACIL 19 63% 2% 19 Search ENILURACIL Search ENILURACIL
5 BETA UREIDOPROPIONASE 15 77% 1% 10 Search BETA+UREIDOPROPIONASE Search BETA+UREIDOPROPIONASE
6 DPYD GENE 14 100% 1% 7 Search DPYD+GENE Search DPYD+GENE
7 DPYS 14 100% 1% 7 Search DPYS Search DPYS
8 DPD DEFICIENCY 12 75% 1% 9 Search DPD+DEFICIENCY Search DPD+DEFICIENCY
9 DIHYDROURACIL 11 57% 1% 13 Search DIHYDROURACIL Search DIHYDROURACIL
10 FLUOROPYRIMIDINE DRUGS 11 100% 0% 6 Search FLUOROPYRIMIDINE+DRUGS Search FLUOROPYRIMIDINE+DRUGS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DPD DEFICIENCY 214 90% 7% 92
2 FAMILIAL PYRIMIDINEMIA 85 73% 5% 66
3 5 FLUOROURACIL TOXICITY 71 75% 4% 51
4 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY 65 51% 7% 91
5 IVS141G GREATER THAN A MUTATION 52 76% 3% 37
6 SEVERE 5 FLUOROURACIL TOXICITY 50 76% 3% 35
7 SEVERE FLUOROURACIL TOXICITY 47 86% 2% 24
8 THYMINE URACILURIA 44 100% 1% 16
9 DIHYDROPYRIMIDINE DEHYDROGENASE ACTIVITY 42 39% 7% 85
10 PYRIMIDINE DEGRADATION 31 76% 2% 22

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity 2011 35 74 82%
Should DPD analysis be required prior to prescribing fluoropyrimidines? 2007 50 47 87%
Routine Dihydropyrimidine Dehydrogenase Testing for Anticipating 5-Fluorouracil-Related Severe Toxicities: Hype or Hope? 2010 24 46 98%
Evaluation of predictive tests for screening for dihydropyrimidine dehydrogenase deficiency 2013 9 67 100%
Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil 2004 193 111 50%
Pharmacokinetically Guided Dose Adjustment of 5-Fluorouracil: A Rational Approach to Improving Therapeutic Outcomes 2009 54 53 60%
Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency 1999 129 58 71%
Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil 2001 63 9 100%
Evaluation of 5-fluorouracil pharmacokinetic models and therapeutic drug monitoring in cancer patients 2013 7 82 77%
Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency 2003 41 30 67%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 INO F 8 70% 0.6% 7
2 ONCOPHARMACOL PHARMACOGENET 5 60% 0.5% 6
3 PHARMACOKINET IMAGING PROGRAM 2 67% 0.2% 2
4 ANTICANC PAUL P IN 1 100% 0.2% 2
5 LOS ANGELES ONCOL 1 50% 0.2% 2
6 BIOMED NMR GRP 1 23% 0.4% 5
7 ANHUI PROVINCIAL HOSP 1 50% 0.1% 1
8 CANC THER EUT BRANCH CANC 1 50% 0.1% 1
9 CENT SPECT R0400 1 50% 0.1% 1
10 CLIN BIOCHEM TOXICOL 1 50% 0.1% 1

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000224969 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYL TRANSFERASE
2 0.0000140941 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//ALPHA D RIBOSE 1 PHOSPHATE
3 0.0000139924 OXALIPLATIN//CAPECITABINE//IRINOTECAN
4 0.0000129008 BIOCHEMICAL MODULATION//LEUCOVORIN//FOLINIC ACID
5 0.0000105772 THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//THYMIDINE PHOSPHORYLASE INHIBITOR
6 0.0000105601 VASCULAR TOXICITY//INTERNAL MED PERIOPERAT ASSESSMENT//BOLUS 5 FLUOROURACIL
7 0.0000087368 HYDANTOINASE//D HYDANTOINASE//L N CARBAMOYLASE
8 0.0000086821 TULAREMIA LIVE VACCINE//1 HEXYLCARBAMOYL 5 FLUOROURACIL//5 FLUOROURACIL AND 1 HEXYLCARBAMOYL 5 FLUOROURACIL
9 0.0000055823 META NISOLDIPINE//VOLTAGE ACTIVATED//M NISOLDIPINE
10 0.0000048709 ADVANCED GASTRIC CANCER//S 1//METASTATIC GASTRIC CANCER