Class information for:
Level 1: BIOCHEMICAL MODULATION//LEUCOVORIN//FOLINIC ACID

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
8496 1179 29.2 57%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
903 10618 DIHYDROPYRIMIDINE DEHYDROGENASE//5 FLUOROURACIL//THYMIDINE PHOSPHORYLASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 BIOCHEMICAL MODULATION Author keyword 13 28% 3% 39
2 LEUCOVORIN Author keyword 13 15% 7% 79
3 FOLINIC ACID Author keyword 8 16% 4% 48
4 5 FLUOROURACIL LEUCOVORIN COMBINATION Author keyword 2 67% 0% 2
5 MTX 5FU Author keyword 2 67% 0% 2
6 NIKAIA GEN HOSP Address 2 67% 0% 2
7 ROFERON AR Author keyword 2 67% 0% 2
8 SEQUENTIAL METHOTREXATE AND 5 FLUOROURACIL Author keyword 2 67% 0% 2
9 5 FU FOLINIC ACID Author keyword 1 100% 0% 2
10 DIETARY FOLATE DEPLETION Author keyword 1 100% 0% 2

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 BIOCHEMICAL MODULATION 13 28% 3% 39 Search BIOCHEMICAL+MODULATION Search BIOCHEMICAL+MODULATION
2 LEUCOVORIN 13 15% 7% 79 Search LEUCOVORIN Search LEUCOVORIN
3 FOLINIC ACID 8 16% 4% 48 Search FOLINIC+ACID Search FOLINIC+ACID
4 5 FLUOROURACIL LEUCOVORIN COMBINATION 2 67% 0% 2 Search 5+FLUOROURACIL+LEUCOVORIN+COMBINATION Search 5+FLUOROURACIL+LEUCOVORIN+COMBINATION
5 MTX 5FU 2 67% 0% 2 Search MTX+5FU Search MTX+5FU
6 ROFERON AR 2 67% 0% 2 Search ROFERON+AR Search ROFERON+AR
7 SEQUENTIAL METHOTREXATE AND 5 FLUOROURACIL 2 67% 0% 2 Search SEQUENTIAL+METHOTREXATE+AND+5+FLUOROURACIL Search SEQUENTIAL+METHOTREXATE+AND+5+FLUOROURACIL
8 5 FU FOLINIC ACID 1 100% 0% 2 Search 5+FU+FOLINIC+ACID Search 5+FU+FOLINIC+ACID
9 DIETARY FOLATE DEPLETION 1 100% 0% 2 Search DIETARY+FOLATE+DEPLETION Search DIETARY+FOLATE+DEPLETION
10 FLUOROURACIL INFUSION 1 50% 0% 2 Search FLUOROURACIL+INFUSION Search FLUOROURACIL+INFUSION

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 BIOCHEMICAL MODULATION 27 26% 8% 89
2 ADVANCED COLORECTAL CARCINOMA 25 30% 6% 70
3 COLON ADENOCARCINOMA XENOGRAFTS 17 68% 1% 15
4 HIGH DOSE LEUCOVORIN 14 14% 8% 91
5 SEQUENTIAL METHOTREXATE 11 30% 3% 30
6 RECOMBINANT BETA INTERFERON 8 70% 1% 7
7 GASTRIC ADENOCARCINOMAS 8 45% 1% 14
8 METASTATIC COLORECTAL CARCINOMA 6 18% 3% 31
9 FLUOROURACIL PLUS CISPLATIN 5 54% 1% 7
10 CONTINUOUS INFUSION FLUOROURACIL 5 22% 2% 19

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Interferons as biomodulators of fluoropyrimidines in the treatment of colorectal cancer 1999 23 50 78%
PRECLINICAL AND CLINICAL ASPECTS OF BIOMODULATION OF 5-FLUOROURACIL 1994 79 126 42%
CHEMOTHERAPEUTIC STRATEGIES IN METASTATIC COLORECTAL-CANCER - AN OVERVIEW OF CURRENT CLINICAL-TRIALS 1992 81 86 72%
ANTINEOPLASTIC ACTIVITY OF THE COMBINATION OF INTERFERON AND CYTOTOXIC AGENTS AGAINST EXPERIMENTAL AND HUMAN MALIGNANCIES - A REVIEW 1990 337 108 48%
Biomodulation of fluorouracil in colorectal cancer 1998 22 92 60%
Chemotherapy for the treatment of patients with metastatic colorectal cancer: An overview 1997 32 73 53%
NEW TARGETS FOR PYRIMIDINE ANTIMETABOLITES IN THE TREATMENT OF SOLID TUMORS .1. THYMIDYLATE SYNTHASE 1994 26 98 54%
Rationale for treatment design: Biochemical modulation of 5-fluorouracil by leucovorin 1998 12 34 62%
CHEMOTHERAPY OF ADVANCED CANCER OF THE COLON AND RECTUM 1991 45 58 57%
CLINICAL RELEVANCE OF BIOCHEMICAL MODULATION OF 5-FLUOROURACIL 1991 66 86 42%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 NIKAIA GEN HOSP 2 67% 0.2% 2
2 BIOSTAT DATA MANAGEMENT SECT CLIN SCI 1 50% 0.1% 1
3 PHARMACEUT CHEM CLIN PHARM 1 50% 0.1% 1
4 SAHLGRENSKA SAHLGRENSKA UNIV HOSP OSTRA 1 50% 0.1% 1
5 1560 SHERBROOKE EST 0 33% 0.1% 1
6 ILLINOIS CANC 0 33% 0.1% 1
7 IMPERIAL CANC FUND HUMAN TUMOUR IMMUNOL GRP 0 33% 0.1% 1
8 SECT GASTROINTESTINAL MED ONCOL 0 33% 0.1% 1
9 AZIENDA OSPED S MARIA 0 25% 0.1% 1
10 LOS ANGELES ONCOL 0 25% 0.1% 1

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000234299 OXALIPLATIN//CAPECITABINE//IRINOTECAN
2 0.0000193257 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//ALPHA D RIBOSE 1 PHOSPHATE
3 0.0000129008 DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY
4 0.0000115812 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYL TRANSFERASE
5 0.0000086236 HEPATIC ARTERIAL INFUSION//HEPATIC ARTERY INFUSION//DEBIRI
6 0.0000075672 ADVANCED GASTRIC CANCER//S 1//METASTATIC GASTRIC CANCER
7 0.0000064799 THYMIDYLATE SYNTHASE//THYX//DEOXYTUBULOSINE
8 0.0000062426 THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//THYMIDINE PHOSPHORYLASE INHIBITOR
9 0.0000061178 7 HYDROXYMETHOTREXATE//GLUCARPIDASE//HIGH DOSE METHOTREXATE
10 0.0000058934 TULAREMIA LIVE VACCINE//1 HEXYLCARBAMOYL 5 FLUOROURACIL//5 FLUOROURACIL AND 1 HEXYLCARBAMOYL 5 FLUOROURACIL