Class information for:
Level 1: PROTEIN FORMULATION//SUBVISIBLE PARTICLES//PROTEIN AGGREGATION

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
9098 1122 40.8 73%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1035 9679 MOLTEN GLOBULE//APOMYOGLOBIN//PROTEIN FORMULATION

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PROTEIN FORMULATION Author keyword 93 49% 12% 138
2 SUBVISIBLE PARTICLES Author keyword 57 95% 2% 19
3 PROTEIN AGGREGATION Author keyword 27 12% 20% 220
4 LATE STAGE PHARMACEUT DEV Address 20 58% 2% 23
5 MACROMOL VACCINE STABILIZAT Address 18 49% 2% 26
6 FORMULAT SCI Address 17 44% 3% 30
7 BIOPHARMACEUTICALS CHARACTERIZATION Author keyword 14 55% 2% 17
8 PROT PHARMACEUT DEV Address 12 75% 1% 9
9 FORMULAT ANALYT OURCES Address 10 46% 2% 17
10 POLYSORBATE Author keyword 10 34% 2% 23

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 PROTEIN FORMULATION 93 49% 12% 138 Search PROTEIN+FORMULATION Search PROTEIN+FORMULATION
2 SUBVISIBLE PARTICLES 57 95% 2% 19 Search SUBVISIBLE+PARTICLES Search SUBVISIBLE+PARTICLES
3 PROTEIN AGGREGATION 27 12% 20% 220 Search PROTEIN+AGGREGATION Search PROTEIN+AGGREGATION
4 BIOPHARMACEUTICALS CHARACTERIZATION 14 55% 2% 17 Search BIOPHARMACEUTICALS+CHARACTERIZATION Search BIOPHARMACEUTICALS+CHARACTERIZATION
5 POLYSORBATE 10 34% 2% 23 Search POLYSORBATE Search POLYSORBATE
6 LIGHT OBSCURATION 9 55% 1% 12 Search LIGHT+OBSCURATION Search LIGHT+OBSCURATION
7 HIGH PROTEIN CONCENTRATION 6 80% 0% 4 Search HIGH+PROTEIN+CONCENTRATION Search HIGH+PROTEIN+CONCENTRATION
8 CROSS INTERACTION CHROMATOGRAPHY 6 71% 0% 5 Search CROSS+INTERACTION+CHROMATOGRAPHY Search CROSS+INTERACTION+CHROMATOGRAPHY
9 RECOMBINANT HUMAN INTERFERON BETA 6 71% 0% 5 Search RECOMBINANT+HUMAN+INTERFERON+BETA Search RECOMBINANT+HUMAN+INTERFERON+BETA
10 STABILIZING PEPTIDE 6 100% 0% 4 Search STABILIZING+PEPTIDE Search STABILIZING+PEPTIDE

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 REVERSIBLE SELF ASSOCIATION 82 85% 4% 44
2 SUBVISIBLE PARTICLES 65 95% 2% 21
3 NONNATIVE PROTEIN AGGREGATION 57 95% 2% 19
4 AGITATION INDUCED AGGREGATION 56 100% 2% 19
5 CONCENTRATION FORMULATIONS 42 94% 1% 15
6 PROTEIN CONCENTRATION SOLUTIONS 34 93% 1% 13
7 CONCENTRATED MONOCLONAL ANTIBODY 28 81% 2% 17
8 ALPHA CHYMOTRYPSINOGEN 27 76% 2% 19
9 NUCLEATED POLYMERIZATION MODEL 23 70% 2% 19
10 POLYSORBATE 20 19 80% 1% 12

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Accelerated Formulation Development of Monoclonal Antibodies (mAbs) and mAb-Based Modalities: Review of Methods and Tools 2015 1 121 46%
High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability 2014 8 89 69%
Mechanisms of Protein Aggregation 2009 77 11 91%
Immunogenicity of therapeutic proteins: Influence of aggregation 2014 11 90 37%
Aggregates in Monoclonal Antibody Manufacturing Processes 2011 64 103 41%
Liquid formulation for antibody drugs 2014 5 64 63%
Protein Aggregation: Pathways, Induction Factors and Analysis 2009 200 163 26%
Forced degradation of therapeutic proteins 2012 32 137 47%
Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation 2003 519 93 27%
Analytical approaches to assess the degradation of therapeutic proteins 2013 8 39 69%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 LATE STAGE PHARMACEUT DEV 20 58% 2.0% 23
2 MACROMOL VACCINE STABILIZAT 18 49% 2.3% 26
3 FORMULAT SCI 17 44% 2.7% 30
4 PROT PHARMACEUT DEV 12 75% 0.8% 9
5 FORMULAT ANALYT OURCES 10 46% 1.5% 17
6 PHARM PHARMACEUT TECHNOL BIOPHARMACEUT 9 25% 2.8% 31
7 PHARMACEUT DEVICE DEV 9 83% 0.4% 5
8 DRUG PROD DEVICE DEV 9 67% 0.7% 8
9 FORMULAT RD BIOL 8 75% 0.5% 6
10 LATE STAGE PHARMACEUT PROC DEV 8 44% 1.2% 14

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000143356 SEDFIT//LAMM EQUATION//DYNAM MACROMOL ASSEMBLY SECT
2 0.0000136777 AGALACTOSYL IGG//PROT ANALYT CHEM//IGG GLYCOSYLATION
3 0.0000132043 BIOSIMILARS//BIOSIMILAR//ANTI ERYTHROPOIETIN ANTIBODIES
4 0.0000129753 FREEZE DRYING//LYOPHILIZATION//FREEZE DRYING LYOPHILIZATION
5 0.0000113189 PREFERENTIAL HYDRATION//PREFERENTIAL INTERACTIONS//PREFERENTIAL INTERACTION
6 0.0000104033 PROTEIN MELTING DOMAINS//THERMAL SHIFT ASSAYS//THERMOFLUOR
7 0.0000081387 S88//THIN FILM RHEOLOGY//HIGH SHEAR RHEOLOGY
8 0.0000070302 TAYLOR DISPERSION ANALYSIS//POLYSTYRENESULFONATES//DOUBLE UV DETECTION POINTS
9 0.0000070169 ISOASPARTATE//PROTEIN L ISOASPARTYL METHYLTRANSFERASE//DEAMIDATION
10 0.0000064989 PROTEIN CRYSTALLIZATION//BIOCRYSTALLIZATION//PROTEIN CRYSTAL GROWTH