Class information for:
Level 1: BETA SECRETASE//BACE1//BACE 1

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
9249 1105 47.4 91%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
14 37098 ALZHEIMERS DISEASE//AMYLOID PRECURSOR PROTEIN//BETA AMYLOID

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 BETA SECRETASE Author keyword 167 55% 19% 207
2 BACE1 Author keyword 126 52% 15% 169
3 BACE 1 Author keyword 89 70% 7% 74
4 BACE Author keyword 66 55% 7% 82
5 MEMAPSIN 2 Author keyword 48 100% 2% 17
6 BACE1 INHIBITOR Author keyword 41 87% 2% 20
7 BACE2 Author keyword 29 77% 2% 20
8 PROT STUDIES PROGRAM Address 27 51% 3% 38
9 BACE1 INHIBITORS Author keyword 21 90% 1% 9
10 BACE 1 INHIBITORS Author keyword 19 76% 1% 13

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 BETA SECRETASE 167 55% 19% 207 Search BETA+SECRETASE Search BETA+SECRETASE
2 BACE1 126 52% 15% 169 Search BACE1 Search BACE1
3 BACE 1 89 70% 7% 74 Search BACE+1 Search BACE+1
4 BACE 66 55% 7% 82 Search BACE Search BACE
5 MEMAPSIN 2 48 100% 2% 17 Search MEMAPSIN+2 Search MEMAPSIN+2
6 BACE1 INHIBITOR 41 87% 2% 20 Search BACE1+INHIBITOR Search BACE1+INHIBITOR
7 BACE2 29 77% 2% 20 Search BACE2 Search BACE2
8 BACE1 INHIBITORS 21 90% 1% 9 Search BACE1+INHIBITORS Search BACE1+INHIBITORS
9 BACE 1 INHIBITORS 19 76% 1% 13 Search BACE+1+INHIBITORS Search BACE+1+INHIBITORS
10 BACE 1 INHIBITOR 15 88% 1% 7 Search BACE+1+INHIBITOR Search BACE+1+INHIBITOR

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 HYDROXY ETHYLAMINES HEAS 86 96% 2% 26
2 BETA SECRETASE ACTIVITY 70 58% 7% 80
3 HUMAN BETA SECRETASE 62 80% 4% 39
4 BETA SECRETASE INHIBITORS 58 75% 4% 42
5 CLEAVING ENZYME 53 48% 7% 82
6 BACE 51 61% 5% 54
7 ASPARTYL PROTEASE 49 42% 8% 90
8 ALZHEIMERS BETA SECRETASE 43 69% 3% 37
9 BACE1 33 38% 6% 69
10 BETA SECRETASE 28 18% 13% 139

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Targeting the beta secretase BACE1 for Alzheimer's disease therapy 2014 46 63 79%
Developing ss-secretase inhibitors for treatment of Alzheimer's disease 2012 82 72 90%
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects 2014 24 202 47%
BACE1 (beta-secretase) inhibitors for the treatment of Alzheimer's disease 2014 13 204 77%
beta-secretase as a therapeutic target for Alzheimer's disease 2008 90 64 94%
Identification and biology of ss-secretase 2012 35 83 81%
The secretases: enzymes with therapeutic potential in Alzheimer disease 2010 202 108 28%
The beta-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease 2011 31 73 86%
The Role of Amyloid Precursor Protein Processing by BACE1, the beta-Secretase, in Alzheimer Disease Pathophysiology 2008 93 56 75%
Advances in the identification of beta-secretase inhibitors 2013 8 104 90%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PROT STUDIES PROGRAM 27 51% 3.4% 38
2 PROTEOM SCI 4 67% 0.4% 4
3 GLYCO CHAIN FUNCT 3 50% 0.5% 5
4 VAH GRECC 3 100% 0.3% 3
5 PEPTIDE SCI 3 35% 0.6% 7
6 HALDEMAN MOL DIAGNOST THER EUT 3 60% 0.3% 3
7 DEMYELINATING DIS AGEING 2 67% 0.2% 2
8 SUPRABIOMOL SYST GRPFRONTIER SYST 2 67% 0.2% 2
9 TOWNSEND FAMILY S PSYCHIAT 2 67% 0.2% 2
10 OKLAHOMA MED FDN 2 11% 1.5% 17

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000195823 PRESENILIN//GAMMA SECRETASE//PRESENILIN 1
2 0.0000122311 AMYLOID PRECURSOR PROTEIN//BETA AMYLOID PRECURSOR PROTEIN//AMYLOID PRECURSOR LIKE PROTEIN
3 0.0000113414 BAPINEUZUMAB//INTRANEURONAL ABETA//SOLANEZUMAB
4 0.0000108115 FE65//ALCADEIN//X11 ALPHA
5 0.0000106258 FAMILIAL DANISH DEMENTIA//BRI2//GLUTAMINYL CYCLASE
6 0.0000070193 MEMORY AND LEARNING IMPAIRMENT//ALZHEIMER KOR KUTATOCSOPORT//FLAP PROTEIN
7 0.0000057459 PSYCHIAT NEUROCHEM//CLIN MEMORY UNIT//UNIT NEUROCHEM
8 0.0000052019 24S HYDROXYCHOLESTEROL//CYP46//24 HYDROXYCHOLESTEROL
9 0.0000051046 SORL1//TOMM40//PICALM
10 0.0000045253 NMR SCREENING//FRAGMENT BASED DRUG DISCOVERY//WATERLOGSY