Class information for:
Level 1: INTERSPECIES SCALING//DMPK TRANSLAT SCI//WELL STIRRED MODEL

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
9503 1082 37.8 64%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1987 5071 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 INTERSPECIES SCALING Author keyword 21 51% 3% 29
2 DMPK TRANSLAT SCI Address 15 88% 1% 7
3 WELL STIRRED MODEL Author keyword 12 63% 1% 12
4 CLEARANCE PREDICTION Author keyword 11 57% 1% 13
5 VOLUME OF DISTRIBUTION Author keyword 10 25% 3% 34
6 COMPUTATIONAL ADME Author keyword 9 43% 1% 16
7 QSPKR Author keyword 8 60% 1% 9
8 DRUG IONIZATION Author keyword 8 100% 0% 5
9 INTRINSIC CLEARANCE Author keyword 8 36% 2% 18
10 WOODMONT OFF 2 Address 8 62% 1% 8

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 INTERSPECIES SCALING 21 51% 3% 29 Search INTERSPECIES+SCALING Search INTERSPECIES+SCALING
2 WELL STIRRED MODEL 12 63% 1% 12 Search WELL+STIRRED+MODEL Search WELL+STIRRED+MODEL
3 CLEARANCE PREDICTION 11 57% 1% 13 Search CLEARANCE+PREDICTION Search CLEARANCE+PREDICTION
4 VOLUME OF DISTRIBUTION 10 25% 3% 34 Search VOLUME+OF+DISTRIBUTION Search VOLUME+OF+DISTRIBUTION
5 COMPUTATIONAL ADME 9 43% 1% 16 Search COMPUTATIONAL+ADME Search COMPUTATIONAL+ADME
6 QSPKR 8 60% 1% 9 Search QSPKR Search QSPKR
7 DRUG IONIZATION 8 100% 0% 5 Search DRUG+IONIZATION Search DRUG+IONIZATION
8 INTRINSIC CLEARANCE 8 36% 2% 18 Search INTRINSIC+CLEARANCE Search INTRINSIC+CLEARANCE
9 HEPATIC CLEARANCE 8 24% 2% 27 Search HEPATIC+CLEARANCE Search HEPATIC+CLEARANCE
10 IN VITRO IN VIVO EXTRAPOLATION 7 30% 2% 20 Search IN+VITRO+IN+VIVO+EXTRAPOLATION Search IN+VITRO+IN+VIVO+EXTRAPOLATION

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PLASMA PARTITION COEFFICIENTS 57 70% 4% 48
2 INTRINSIC CLEARANCE 54 42% 9% 98
3 HUMAN DRUG CLEARANCE 52 80% 3% 32
4 HEPATIC METABOLIC CLEARANCE 47 81% 3% 29
5 ANIMAL DATA 33 75% 2% 24
6 IN VITRO DATA 28 31% 7% 74
7 HEPATIC CLEARANCE 24 36% 5% 54
8 NONSPECIFIC BINDING 17 27% 5% 54
9 ANTIPYRINE INTRINSIC CLEARANCE 17 100% 1% 8
10 VERTICAL ALLOMETRY 17 100% 1% 8

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data 2015 6 55 31%
Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science 2011 161 164 27%
A novel strategy for physiologically based predictions of human pharmacokinetics 2006 155 60 77%
Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches 2009 102 44 52%
The application of allometric scaling principles to predict pharmacokinetic parameters across species 2014 5 42 79%
The Simcyp (R) Population-based ADME Simulator 2009 123 36 42%
Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development: A Pharmaceutical Industry Perspective 2015 1 61 48%
Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches 2013 11 93 54%
Application of PBPK modelling in drug discovery and development at Pfizer 2012 21 93 51%
Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development 2007 45 30 83%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DMPK TRANSLAT SCI 15 88% 0.6% 7
2 WOODMONT OFF 2 8 62% 0.7% 8
3 PL PHARMACOKINET 8 18% 3.5% 38
4 DISCOVERY ADME TOX 3 50% 0.5% 5
5 CLIN PHARMACOL TOXICOL BRANCH HFD 579 3 100% 0.3% 3
6 THER EUT DRUGS FOOD ANIM HFV 130 3 100% 0.3% 3
7 GLOBAL PK PD PHARMACOMETR 3 45% 0.5% 5
8 BLADES ENTERPRISE 3 17% 1.4% 15
9 SYST BIOL COMPUTAT SOLUT 2 67% 0.2% 2
10 PHARMACEUT EVALUAT 1 2 30% 0.6% 6

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000185594 CYP3A//COCKTAIL//MECHANISM BASED INHIBITION
2 0.0000136297 BOF 4272//MULTIPLE INDICATOR DILUTION//HEPATIC ELIMINATION
3 0.0000124298 HUMAN INTESTINAL ABSORPTION//PAMPA//LOG BB
4 0.0000116996 METHYLHIPPURIC ACID//HIPPURIC ACID//PBPK MODELING
5 0.0000096328 OATP1B1//SLCO1B1//OATP
6 0.0000093831 ORAL PHARMACOL THER EUT//PHARMACEUT SCI BIOPHARMACEUT MIZUHO KU//31 TANABE DORIMIZUHO KU
7 0.0000084792 INO 2628 CZ//DOUBLE PEAKS//DISCONTINUOUS ABSORPTION
8 0.0000083553 P PHENYLBENZOIC ACID//CPDPN//DEVELOPING FETUS
9 0.0000078696 LIVER SLICES//PRECISION CUT TISSUE SLICES//PRECISION CUT LIVER SLICES
10 0.0000077837 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//DISTRIBUTION CLEARANCE//CURVE MOMENTS