Class information for:
Level 1: PRESENILIN//GAMMA SECRETASE//PRESENILIN 1

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
982 2833 49.6 93%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
14 37098 ALZHEIMERS DISEASE//AMYLOID PRECURSOR PROTEIN//BETA AMYLOID

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PRESENILIN Author keyword 419 62% 15% 437
2 GAMMA SECRETASE Author keyword 293 57% 12% 347
3 PRESENILIN 1 Author keyword 224 60% 9% 244
4 NICASTRIN Author keyword 146 85% 3% 76
5 PRESENILIN 2 Author keyword 87 73% 2% 67
6 PRESENILINS Author keyword 79 62% 3% 82
7 PEN 2 Author keyword 62 92% 1% 24
8 APH 1 Author keyword 53 95% 1% 18
9 GAMMA SECRETASE COMPLEX Author keyword 53 95% 1% 18
10 GAMMA SECRETASE MODULATOR Author keyword 47 88% 1% 22

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 PRESENILIN 419 62% 15% 437 Search PRESENILIN Search PRESENILIN
2 GAMMA SECRETASE 293 57% 12% 347 Search GAMMA+SECRETASE Search GAMMA+SECRETASE
3 PRESENILIN 1 224 60% 9% 244 Search PRESENILIN+1 Search PRESENILIN+1
4 NICASTRIN 146 85% 3% 76 Search NICASTRIN Search NICASTRIN
5 PRESENILIN 2 87 73% 2% 67 Search PRESENILIN+2 Search PRESENILIN+2
6 PRESENILINS 79 62% 3% 82 Search PRESENILINS Search PRESENILINS
7 PEN 2 62 92% 1% 24 Search PEN+2 Search PEN+2
8 APH 1 53 95% 1% 18 Search APH+1 Search APH+1
9 GAMMA SECRETASE COMPLEX 53 95% 1% 18 Search GAMMA+SECRETASE+COMPLEX Search GAMMA+SECRETASE+COMPLEX
10 GAMMA SECRETASE MODULATOR 47 88% 1% 22 Search GAMMA+SECRETASE+MODULATOR Search GAMMA+SECRETASE+MODULATOR

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 NICASTRIN 320 81% 7% 191
2 FAMILIAL ALZHEIMERS DISEASE 214 32% 20% 555
3 PRESENILIN 193 59% 8% 218
4 ENDOPROTEOLYSIS 188 76% 5% 130
5 GAMMA SECRETASE ACTIVITY 187 51% 9% 263
6 APH 1 167 89% 3% 77
7 PEN 2 143 88% 2% 67
8 BETA PEPTIDE PRODUCTION 111 83% 2% 63
9 TRANSMEMBRANE ASPARTATES 107 80% 2% 67
10 AMYLOID PRECURSOR PROTEIN 102 10% 33% 949

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Learning by Failing: Ideas and Concepts to Tackle gamma-Secretases in Alzheimer's Disease and Beyond 2015 5 133 80%
Alzheimer's disease: Genes, proteins, and therapy 2001 3230 204 31%
Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex 2003 524 18 100%
Novel Research Horizons for Presenilins and gamma-Secretases in Cell Biology and Disease 2010 100 144 80%
?-Secretase inhibitors and modulators for Alzheimer's disease 2012 52 71 96%
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics 2011 362 131 21%
Amyloid, the presenilins and Alzheimer's disease 1997 1005 40 65%
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation 2004 301 47 66%
Intramembrane Proteolysis by gamma-Secretase 2008 98 61 87%
Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective 2005 787 96 25%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 NEUROPATHOL NEUROSCI 30 33% 2.6% 75
2 ADOLF BUTENANDT 14 15% 3.0% 84
3 ALZHEIMERS PARKINSONS DIS 13 28% 1.4% 40
4 NEURONAL CELL BIOL GENE TRANSFER 13 55% 0.6% 16
5 MOL NEURODEGENERAT GRP 11 78% 0.2% 7
6 GRP CHEM BIOL NEURODEGENERAT DIS 9 83% 0.2% 5
7 MOL NEUROPATHOGENESIS 9 67% 0.3% 8
8 MOL BIOL GENET NEURODEGENERAT 8 70% 0.2% 7
9 DEMYELINATING DIS AGING 6 25% 0.7% 21
10 CLEMENS OPF CHEM BIOCHEM 6 47% 0.3% 9

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000222237 FE65//ALCADEIN//X11 ALPHA
2 0.0000195823 BETA SECRETASE//BACE1//BACE 1
3 0.0000134164 AMYLOID PRECURSOR PROTEIN//BETA AMYLOID PRECURSOR PROTEIN//AMYLOID PRECURSOR LIKE PROTEIN
4 0.0000113356 BAPINEUZUMAB//INTRANEURONAL ABETA//SOLANEZUMAB
5 0.0000102299 ALPHA 1 ANTICHYMOTRYPSIN//D10S1423//PSYCHIATGERONTOL UNIT
6 0.0000093037 AMYLOID PRECURSOR PROTEIN GENE//BRAIN INJURY DEMENTIA//FAMILIAL ALZHEIMER
7 0.0000089034 FAMILIAL DANISH DEMENTIA//BRI2//GLUTAMINYL CYCLASE
8 0.0000086860 SORL1//TOMM40//PICALM
9 0.0000079117 NEUROONTOGENESIS//JCASP//FUNCT BIOCHEM NERVOUS SYST
10 0.0000074739 HUMANIN//COLIVELIN//S14G HUMANIN