Class information for:
Level 2: ROLIPRAM//PHOSPHODIESTERASE//PDE4

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
1104 9294 42.4 78%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
311 35831 ROLIPRAM//RHO KINASE//PHOSPHODIESTERASE

Classes in level below (level 1)


ID, lev. below Publications Label for level below
643 3133 ROLIPRAM//PDE4//PHOSPHODIESTERASE
7816 1246 CELLULAR BIOCHEM SECT//8 CL CAMP//8 CHLORO ADENOSINE
9353 1095 CAPK//CAMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT//PATHOCHEM
9989 1037 ADENYLYL CYCLASE//ABT PHARMAZEUT BIOCHEM//P SITE INHIBITOR
10424 998 YC 1//BAY 41 2272//SOLUBLE GUANYLYL CYCLASE
13675 757 GRAVIN//AKAP//A KINASE ANCHORING PROTEIN
15254 653 TYPE II CGMP DEPENDENT PROTEIN KINASE//CGMP DEPENDENT PROTEIN KINASE//CANC MOL BIOL SECT
21032 375 PDE 5 INHIBITION//PDE5//PHOSPHODIESTERASE 5

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 ROLIPRAM Author keyword 202 56% 3% 246
2 PHOSPHODIESTERASE Author keyword 169 32% 5% 439
3 PDE4 Author keyword 158 72% 1% 125
4 PDE10A Author keyword 102 89% 1% 47
5 GRAVIN Author keyword 77 96% 0% 24
6 YC 1 Author keyword 74 62% 1% 76
7 BAY 41 2272 Author keyword 64 82% 0% 37
8 PDE4 INHIBITOR Author keyword 59 71% 1% 48
9 A KINASE ANCHORING PROTEIN AKAP Author keyword 58 88% 0% 28
10 PHOSPHODIESTERASE 4 Author keyword 58 58% 1% 66

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 ROLIPRAM 202 56% 3% 246 Search ROLIPRAM Search ROLIPRAM
2 PHOSPHODIESTERASE 169 32% 5% 439 Search PHOSPHODIESTERASE Search PHOSPHODIESTERASE
3 PDE4 158 72% 1% 125 Search PDE4 Search PDE4
4 PDE10A 102 89% 1% 47 Search PDE10A Search PDE10A
5 GRAVIN 77 96% 0% 24 Search GRAVIN Search GRAVIN
6 YC 1 74 62% 1% 76 Search YC+1 Search YC+1
7 BAY 41 2272 64 82% 0% 37 Search BAY+41+2272 Search BAY+41+2272
8 PDE4 INHIBITOR 59 71% 1% 48 Search PDE4+INHIBITOR Search PDE4+INHIBITOR
9 A KINASE ANCHORING PROTEIN AKAP 58 88% 0% 28 Search A+KINASE+ANCHORING+PROTEIN+AKAP Search A+KINASE+ANCHORING+PROTEIN+AKAP
10 PHOSPHODIESTERASE 4 58 58% 1% 66 Search PHOSPHODIESTERASE+4 Search PHOSPHODIESTERASE+4

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CYCLIC NUCLEOTIDE PHOSPHODIESTERASES 531 47% 9% 830
2 CAMP SPECIFIC PHOSPHODIESTERASE 386 77% 3% 261
3 AMP SPECIFIC PHOSPHODIESTERASE 261 95% 1% 89
4 ROLIPRAM 261 66% 3% 245
5 AMP PHOSPHODIESTERASE 149 64% 2% 146
6 REGULATORY SUBUNIT RII 146 88% 1% 70
7 PDE4 INHIBITORS 130 71% 1% 104
8 NUCLEOTIDE PHOSPHODIESTERASE 112 50% 2% 163
9 CAMP PHOSPHODIESTERASE 100 53% 1% 134
10 NUCLEOTIDE PHOSPHODIESTERASES 95 63% 1% 95

Journals


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 ADVANCES IN CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH 6 20% 0% 27
2 JOURNAL OF CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH 6 21% 0% 25
3 ADVANCES IN SECOND MESSENGER AND PHOSPHOPROTEIN RESEARCH 4 16% 0% 25
4 ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 2 19% 0% 12
5 JOURNAL OF CYCLIC NUCLEOTIDE RESEARCH 2 15% 0% 14
6 SECOND MESSENGERS AND PHOSPHOPROTEINS 2 18% 0% 11

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Advances in targeting cyclic nucleotide phosphodiesterases 2014 39 244 68%
Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use 2006 698 246 76%
Biochemistry and physiology of cyclic nucleotide Phosphocliesterases: Essential components in cyclic nucleotide signaling 2007 471 170 69%
Structure and Regulation of Soluble Guanylate Cyclase 2012 85 164 77%
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents 2006 399 334 76%
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions 2011 122 397 70%
Overview of PDEs and their regulation 2007 265 168 88%
Protein kinases: evolution of dynamic regulatory proteins 2011 157 54 54%
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action 2010 210 454 54%
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization 2003 419 120 87%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 ABT PHARMAZEUT BIOCHEM 35 89% 0.2% 16
2 CELLULAR BIOCHEM SECT 26 55% 0.4% 33
3 PHARMACOMETR PHARMACOKINET 13 71% 0.1% 10
4 CARDIAC SIGNAL TRANSDUCT CELLULAR BIOL 10 73% 0.1% 8
5 MOL PHARMACOL GRP 9 15% 0.6% 56
6 CANC MOL BIOL SECT 9 83% 0.1% 5
7 INTERDISCIPLINARY STEM CELL PEDIAT 9 83% 0.1% 5
8 MED FAK MA N1 8 100% 0.1% 5
9 PHARMACOL TOXICOL CLIN PHARM 7 41% 0.1% 13
10 DIPARTIMENTO BIOL PATOL MOL CELLULARE 6 40% 0.1% 12

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000016137 CU GNRH//GRP MED PHARMACOL TOXICOL//GRP GYNAECOL ONCOL
2 0.0000011447 NADPH DIAPHORASE//7 NITROINDAZOLE//NEURONAL NITRIC OXIDE SYNTHASE
3 0.0000010819 PROTEIN KINASE CK2//CASEIN KINASE 2//CK2
4 0.0000010783 CILOSTAZOL//CLIN PHARMACOKINET PHARMACODYNAM METAB//AZECINES
5 0.0000008081 ATRIAL NATRIURETIC PEPTIDE//C TYPE NATRIURETIC PEPTIDE//ATRIAL NATRIURETIC FACTOR
6 0.0000007729 NITRATE TOLERANCE//NITROGLYCERIN//ORGANIC NITRATES
7 0.0000007168 FARNESYLTRANSFERASE//PALMITOYLATION//RLIP76
8 0.0000006742 COFFIN LOWRY SYNDROME//ERK5//JNK
9 0.0000006597 LEVOSIMENDAN//CALCIUM SENSITIZERS//CALCIUM SENSITIZER
10 0.0000006566 CHLOROETHYLCLONIDINE//ALPHA1 ADRENOCEPTOR SUBTYPE//BETA3 ADRENOCEPTORS