Class information for:
Level 2: FOLATE RECEPTOR//REDUCED FOLATE CARRIER//DIHYDROFOLATE REDUCTASE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
1587 6631 35.4 65%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
263 40791 HOMOCYSTEINE//FOLATE//FOLIC ACID

Classes in level below (level 1)


ID, lev. below Publications Label for level below
2239 2239 REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//HEREDITARY FOLATE MALABSORPTION
6999 1342 DIHYDROFOLATE REDUCTASE//HYDROGEN TUNNELING//PROMOTING VIBRATION
10035 1034 FOLATE RECEPTOR//FOLATE BINDING PROTEIN//FOLATE RECEPTOR ALPHA
14826 678 7 HYDROXYMETHOTREXATE//GLUCARPIDASE//HIGH DOSE METHOTREXATE
16698 575 HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE
17500 532 THYMIDYLATE SYNTHASE//THYX//DEOXYTUBULOSINE
25533 231 INTESTINAL DAMAGE//SOYBEAN CONCENTRATE//ADJUVANT FREUND INDUCED ARTHRITIS

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 FOLATE RECEPTOR Author keyword 188 59% 3% 212
2 REDUCED FOLATE CARRIER Author keyword 108 69% 1% 91
3 DIHYDROFOLATE REDUCTASE Author keyword 100 37% 3% 214
4 FOLYLPOLYGLUTAMATE SYNTHETASE Author keyword 67 78% 1% 45
5 ANTIFOLATE Author keyword 63 50% 1% 91
6 FOLATE BINDING PROTEIN Author keyword 44 60% 1% 48
7 FOLATE RECEPTOR ALPHA Author keyword 44 72% 1% 34
8 ANTIFOLATES Author keyword 42 47% 1% 67
9 HEREDITARY FOLATE MALABSORPTION Author keyword 41 100% 0% 15
10 PROTON COUPLED FOLATE TRANSPORTER Author keyword 40 79% 0% 26

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 FOLATE RECEPTOR 188 59% 3% 212 Search FOLATE+RECEPTOR Search FOLATE+RECEPTOR
2 REDUCED FOLATE CARRIER 108 69% 1% 91 Search REDUCED+FOLATE+CARRIER Search REDUCED+FOLATE+CARRIER
3 DIHYDROFOLATE REDUCTASE 100 37% 3% 214 Search DIHYDROFOLATE+REDUCTASE Search DIHYDROFOLATE+REDUCTASE
4 FOLYLPOLYGLUTAMATE SYNTHETASE 67 78% 1% 45 Search FOLYLPOLYGLUTAMATE+SYNTHETASE Search FOLYLPOLYGLUTAMATE+SYNTHETASE
5 ANTIFOLATE 63 50% 1% 91 Search ANTIFOLATE Search ANTIFOLATE
6 FOLATE BINDING PROTEIN 44 60% 1% 48 Search FOLATE+BINDING+PROTEIN Search FOLATE+BINDING+PROTEIN
7 FOLATE RECEPTOR ALPHA 44 72% 1% 34 Search FOLATE+RECEPTOR+ALPHA Search FOLATE+RECEPTOR+ALPHA
8 ANTIFOLATES 42 47% 1% 67 Search ANTIFOLATES Search ANTIFOLATES
9 HEREDITARY FOLATE MALABSORPTION 41 100% 0% 15 Search HEREDITARY+FOLATE+MALABSORPTION Search HEREDITARY+FOLATE+MALABSORPTION
10 PROTON COUPLED FOLATE TRANSPORTER 40 79% 0% 26 Search PROTON+COUPLED+FOLATE+TRANSPORTER Search PROTON+COUPLED+FOLATE+TRANSPORTER

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 FOLATE ANALOGS 150 85% 1% 79
2 DENOVO PURINE SYNTHESIS 138 89% 1% 63
3 GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE 113 91% 1% 48
4 N 10 PROPARGYL 5 8 DIDEAZAFOLIC ACID 103 91% 1% 42
5 10 PROPARGYL 5 8 DIDEAZAFOLATE 102 100% 0% 30
6 GAMMA GLUTAMATE SYNTHETASE 92 67% 1% 84
7 TRANSPORT DEFICIENT 90 96% 0% 27
8 5 10 DIDEAZA 5 6 7 8 TETRAHYDROFOLATE 79 87% 1% 39
9 TRIMETREXATE 74 64% 1% 72
10 CB3717 73 85% 1% 39

Journals


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 ADVANCES IN ENZYME REGULATION 4 10% 0% 33

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Discovery and development of folic-acid-based receptor targeting for Imaging and therapy of cancer and inflammatory diseases 2008 356 60 80%
Role of Dynamics in Enzyme Catalysis: Substantial versus Semantic Controversies 2015 4 44 84%
Folate-targeted therapeutic and imaging agents for cancer 2009 175 52 77%
Engineering Folate-Drug Conjugates to Target Cancer: From Chemistry to Clinic 2012 49 41 85%
Targeted drug delivery via the folate receptor 2000 598 82 49%
THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE 1995 459 116 68%
Perspectives on Electrostatics and Conformational Motions in Enzyme Catalysis 2015 3 44 55%
Folate receptor-mediated drug targeting: From therapeutics to diagnostics 2005 271 129 64%
Folate receptors 1996 312 79 86%
Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance 2012 50 359 76%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 EXPT CLIN THER EUT PROGRAM 24 57% 0.4% 28
2 PROGRAM MOL PHARMACOL EXPT THER EUT 11 50% 0.2% 16
3 AUTOIMMUNE SEROL 9 59% 0.2% 10
4 FRED WYSZKOWSKI CANC 6 31% 0.3% 17
5 TRANSLAT MED DIAGNOST 4 75% 0.0% 3
6 GRACE CANC DRUG 3 13% 0.4% 25
7 10065 BARNES CANYON RD 3 100% 0.0% 3
8 COMPUTAT MOL BIOL DRUG DESIGN GRP 3 45% 0.1% 5
9 USZ 3 21% 0.2% 12
10 PENNY COLE HEMATOL 3 60% 0.0% 3

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000013191 DIHYDROPYRIMIDINE DEHYDROGENASE//5 FLUOROURACIL//THYMIDINE PHOSPHORYLASE
2 0.0000009414 LIPOYL DOMAIN//PYRUVATE DEHYDROGENASE COMPLEX//NONKETOTIC HYPERGLYCINEMIA
3 0.0000008973 HOMOCYSTEINE//FOLATE//FOLIC ACID
4 0.0000006994 THIOPURINE METHYLTRANSFERASE//6 MERCAPTOPURINE//THIOPURINE S METHYLTRANSFERASE
5 0.0000006371 JOURNAL OF MOLECULAR GRAPHICS//HOPFIELD STYLE NETWORK//DRUG DOCKING
6 0.0000006197 HPMA COPOLYMERS//HPMA COPOLYMER//PEGYLATION
7 0.0000006180 LESCH NYHAN SYNDROME//TIAZOFURIN//LESCH NYHAN DISEASE
8 0.0000005947 PNEUMOCYSTIS CARINII//PNEUMOCYSTIS JIROVECII//PNEUMOCYSTIS CARINII PNEUMONIA
9 0.0000005637 RHEUMATOID ARTHRITIS//RHEUMATOLOGY//RHEUMATOL
10 0.0000005199 RIBONUCLEOTIDE REDUCTASE//TRIMIDOX//DIDOX