Class information for:
Level 2: O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE//ALKYLTRANSFERASE//O 6 BENZYLGUANINE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
2084 4777 32.6 59%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
75 80922 MUTATION RESEARCH//TOXICOLOGY//CARCINOGENESIS

Classes in level below (level 1)


ID, lev. below Publications Label for level below
1472 2549 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE//O 6 BENZYLGUANINE//ALKYLTRANSFERASE
13846 745 SARCNU//TAUROMUSTINE//S 2250 KAWAGISHI
16247 598 BIS TRIAZENE//TRIAZENE//BISTRIAZENE
19491 438 MTIC//DIPARTIMENTO FARMACOCHIM TOSSICOL BIOL//VLAK PROTOCOL
23525 288 VNP40101M//CLORETAZINE//NEW ANTICANCER AGENT
28988 159 TRIMELAMOL//HEXAMETHYLMELAMINE//DEHYDROEMETINE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE Author keyword 140 86% 1% 70
2 ALKYLTRANSFERASE Author keyword 102 86% 1% 51
3 O 6 BENZYLGUANINE Author keyword 93 80% 1% 57
4 O 6 METHYLGUANINE DNA METHYLTRANSFERASE Author keyword 81 55% 2% 102
5 O 6 METHYLGUANINE Author keyword 50 61% 1% 54
6 MGMT Author keyword 39 24% 3% 140
7 LOMEGUATRIB Author keyword 34 93% 0% 13
8 CANC UK CARCINOGENESIS GRP Address 31 61% 1% 33
9 BIS TRIAZENE Author keyword 30 100% 0% 12
10 O 6 ALKYLGUANINE Author keyword 27 92% 0% 11

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 140 86% 1% 70 Search O+6+ALKYLGUANINE+DNA+ALKYLTRANSFERASE Search O+6+ALKYLGUANINE+DNA+ALKYLTRANSFERASE
2 ALKYLTRANSFERASE 102 86% 1% 51 Search ALKYLTRANSFERASE Search ALKYLTRANSFERASE
3 O 6 BENZYLGUANINE 93 80% 1% 57 Search O+6+BENZYLGUANINE Search O+6+BENZYLGUANINE
4 O 6 METHYLGUANINE DNA METHYLTRANSFERASE 81 55% 2% 102 Search O+6+METHYLGUANINE+DNA+METHYLTRANSFERASE Search O+6+METHYLGUANINE+DNA+METHYLTRANSFERASE
5 O 6 METHYLGUANINE 50 61% 1% 54 Search O+6+METHYLGUANINE Search O+6+METHYLGUANINE
6 MGMT 39 24% 3% 140 Search MGMT Search MGMT
7 LOMEGUATRIB 34 93% 0% 13 Search LOMEGUATRIB Search LOMEGUATRIB
8 BIS TRIAZENE 30 100% 0% 12 Search BIS+TRIAZENE Search BIS+TRIAZENE
9 O 6 ALKYLGUANINE 27 92% 0% 11 Search O+6+ALKYLGUANINE Search O+6+ALKYLGUANINE
10 TRIAZENE 27 44% 1% 47 Search TRIAZENE Search TRIAZENE

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 360 57% 9% 429
2 O6 METHYLGUANINE DNA METHYLTRANSFERASE 329 79% 4% 208
3 O6 ALKYLGUANINE DNA ALKYLTRANSFERASE 236 88% 2% 113
4 O6 BENZYLGUANINE 202 93% 2% 77
5 ALKYLATING AGENTS 197 28% 12% 588
6 HUMAN O6 ALKYLGUANINE DNA ALKYLTRANSFERASE 131 79% 2% 85
7 O 6 METHYLGUANINE DNA METHYLTRANSFERASE 121 36% 6% 268
8 HUMAN O6 METHYLGUANINE DNA METHYLTRANSFERASE 117 93% 1% 43
9 HUMAN O 6 METHYLGUANINE DNA METHYLTRANSFERASE 104 84% 1% 57
10 HUMAN O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 102 73% 2% 78

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
MGMT: Its role in cancer aetiology and cancer therapeutics 2004 363 118 82%
MAMMALIAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE - REGULATION AND IMPORTANCE IN RESPONSE TO ALKYLATING CARCINOGENIC AND THERAPEUTIC AGENTS 1990 736 161 94%
STRUCTURE, FUNCTION, AND INHIBITION OF O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE 1995 344 247 89%
Repair of O-6-alkylguanine by alkyltransferases 2000 351 135 86%
Balancing repair and tolerance of DNA damage caused by alkylating agents 2012 103 196 33%
Temozolomide: A review of its discovery, chemical properties, pre-clinical development and clinical trials 1997 382 78 76%
MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents 2007 207 197 58%
Clinical relevance of MGMT in the treatment of cancer 2002 241 94 81%
Multifaceted Roles of Alkyltransferase and Related Proteins in DNA Repair, DNA Damage, Resistance to Chemotherapy, and Research Tools 2011 42 249 67%
O-6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry 2011 43 166 57%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CANC UK CARCINOGENESIS GRP 31 61% 0.7% 33
2 S 2250 KAWAGISHI 8 100% 0.1% 5
3 DIPARTIMENTO FARMACOCHIM TOSSICOL BIOL 8 23% 0.6% 29
4 PL TOXICOL 7 20% 0.6% 29
5 MED BIOREGULAT BIOCHEM 6 100% 0.1% 4
6 SECT GENOME DAMAGE REPAIR 5 32% 0.3% 12
7 SEZ CHIM FARMACEUT BIOL 4 40% 0.2% 8
8 CRC SECT GENOME DAMAGE REPAIR 3 57% 0.1% 4
9 MOL CELL BIOL CHEM CARCINOGENESIS 3 100% 0.1% 3
10 PATERSON CANC CARCINOGENESIS 3 100% 0.1% 3

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000021651 N NITROSAMINES//NDMA//N NITROSODIMETHYLAMINE NDMA
2 0.0000011787 XERODERMA PIGMENTOSUM//COCKAYNE SYNDROME//NUCLEOTIDE EXCISION REPAIR
3 0.0000011639 BASE EXCISION REPAIR//DNA GLYCOSYLASE//URACIL DNA GLYCOSYLASE
4 0.0000009454 MUTATION RESEARCH//MUTAGENESIS//MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
5 0.0000008758 TRANSLESION SYNTHESIS//DNA POLYMERASE//RECA PROTEIN
6 0.0000008293 EPENDYMOMA//MEDULLOBLASTOMA//GLIOBLASTOMA
7 0.0000007075 BLOOD BRAIN BARRIER//SUICIDE TRANSPORT//INTRACAROTID CHEMOTHERAPY
8 0.0000007033 1 HYDROXYPYRENE//POLYCYCLIC AROMATIC HYDROCARBONS//DNA ADDUCTS
9 0.0000006857 CONVECTION ENHANCED DELIVERY//GLIADEL//CARMUSTINE WAFERS
10 0.0000006757 METHYLAZOXYMETHANOL//MICRENCEPHALY//EMBRYOL TERATOL