Class information for:
Level 1: TNP 470//METHIONINE AMINOPEPTIDASE//AGM 1470

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11916 945 38.9 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
518 3       ANGIOGENESIS//RETINOPATHY OF PREMATURITY//ENDOSTATIN 20826
361 2             ANGIOGENESIS//ENDOSTATIN//VEGF 17372
11916 1                   TNP 470//METHIONINE AMINOPEPTIDASE//AGM 1470 945

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TNP 470 authKW 3010190 13% 78% 119
2 METHIONINE AMINOPEPTIDASE authKW 1264766 6% 69% 57
3 AGM 1470 authKW 589388 2% 79% 23
4 FUMAGILLIN authKW 512354 4% 39% 41
5 METAP2 authKW 448616 2% 73% 19
6 OVALICIN authKW 261718 1% 90% 9
7 BENGAMIDES authKW 258488 1% 100% 8
8 METHIONINE AMINOPEPTIDASE 2 authKW 217193 1% 61% 11
9 P67 authKW 195472 1% 55% 11
10 FUMAGILLOL authKW 193866 1% 100% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 2675 29% 0% 270
2 Chemistry, Medicinal 1024 10% 0% 98
3 Chemistry, Organic 525 12% 0% 114
4 Biochemistry & Molecular Biology 425 21% 0% 201
5 Pharmacology & Pharmacy 336 13% 0% 126
6 Biophysics 55 4% 0% 37
7 Ophthalmology 46 3% 0% 24
8 Cell Biology 28 5% 0% 47
9 Biotechnology & Applied Microbiology 17 3% 0% 32
10 Surgery 16 5% 0% 44

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HIGH THROUGHPUT SCREENING 85248 2% 16% 16
2 SHANGHAI MAT MEDCHINESE DRUG SCREE 72698 0% 75% 3
3 GYNECOL PREVENT MED 64622 0% 100% 2
4 CHINESE DRUG SCREENING 43068 1% 17% 8
5 ANTI INFECT FOCUS AREA 32311 0% 100% 1
6 ATLANTHERA 32311 0% 100% 1
7 ATLANTIC BONE SCREEN 32311 0% 100% 1
8 BIOL TUMEURS PR M FAVROT 32311 0% 100% 1
9 BIOTA HOLDINGS INC 32311 0% 100% 1
10 BOSTON CHILDRENS HOSPVASC BIOL PROGRAM 32311 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INVASION & METASTASIS 2644 1% 1% 6
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1186 3% 0% 31
3 JAPANESE JOURNAL OF CANCER RESEARCH 1085 1% 0% 11
4 ANTICANCER RESEARCH 859 2% 0% 23
5 CHEMISTRY & BIOLOGY 762 1% 0% 8
6 SURVEY OF OPHTHALMOLOGY 732 1% 0% 6
7 CANCER JOURNAL - FRANCE 528 0% 1% 2
8 JOURNAL OF ANTIBIOTICS 468 1% 0% 10
9 BIOCHEMISTRY 430 3% 0% 28
10 CANCER RESEARCH 401 2% 0% 23

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TNP 470 3010190 13% 78% 119 Search TNP+470 Search TNP+470
2 METHIONINE AMINOPEPTIDASE 1264766 6% 69% 57 Search METHIONINE+AMINOPEPTIDASE Search METHIONINE+AMINOPEPTIDASE
3 AGM 1470 589388 2% 79% 23 Search AGM+1470 Search AGM+1470
4 FUMAGILLIN 512354 4% 39% 41 Search FUMAGILLIN Search FUMAGILLIN
5 METAP2 448616 2% 73% 19 Search METAP2 Search METAP2
6 OVALICIN 261718 1% 90% 9 Search OVALICIN Search OVALICIN
7 BENGAMIDES 258488 1% 100% 8 Search BENGAMIDES Search BENGAMIDES
8 METHIONINE AMINOPEPTIDASE 2 217193 1% 61% 11 Search METHIONINE+AMINOPEPTIDASE+2 Search METHIONINE+AMINOPEPTIDASE+2
9 P67 195472 1% 55% 11 Search P67 Search P67
10 FUMAGILLOL 193866 1% 100% 6 Search FUMAGILLOL Search FUMAGILLOL

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MAURIZ, JL , MARTIN-RENEDO, J , GARCIA-PALOMO, A , TUNON, MJ , GONZALEZ-GALLEGO, J , (2010) METHIONINE AMINOPEPTIDASES AS POTENTIAL TARGETS FOR TREATMENT OF GASTROINTESTINAL CANCERS AND OTHER TUMORS.CURRENT DRUG TARGETS. VOL. 11. ISSUE 11. P. 1430-1448 94 69% 3
2 YIN, SQ , WANG, JJ , ZHANG, CM , LIU, ZP , (2012) THE DEVELOPMENT OF METAP-2 INHIBITORS IN CANCER TREATMENT.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 7. P. 1021-1035 61 81% 20
3 ZHANG, FR , BHAT, S , GABELLI, SB , CHEN, XC , MILLER, MS , NACEV, BA , CHENG, YL , MEYERS, DJ , TENNEY, K , SHIM, JS , ET AL (2013) PYRIDINYLQUINAZOLINES SELECTIVELY INHIBIT HUMAN METHIONINE AMINOPEPTIDASE-1 IN CELLS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 10. P. 3996 -4016 65 77% 3
4 HELGREN, TR , WANGTRAKULDEE, P , STAKER, BL , HAGEN, TJ , (2016) ADVANCES IN BACTERIAL METHIONINE AMINOPEPTIDASE INHIBITION.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 4. P. 397 -414 55 86% 0
5 DATTA, B , (2009) ROLES OF P67/METAP2 AS A TUMOR SUPPRESSOR.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1796. ISSUE 2. P. 281 -292 69 78% 14
6 MARTIN-GALVEZ, F , GARCIA-RUIZ, C , SANCHEZ-RUIZ, A , VALERIOTE, FA , SARABIA, F , (2013) AN ARRAY OF BENGAMIDE E ANALOGUES MODIFIED AT THE TERMINAL OLEFINIC POSITION: SYNTHESIS AND ANTITUMOR PROPERTIES.CHEMMEDCHEM. VOL. 8. ISSUE 5. P. 819 -831 57 75% 2
7 BERNIER, SG , WESTLIN, WF , HANNIG, G , (2005) FUMAGILLIN CLASS INHIBITORS OF METHIONINE AMINOPEPTIDASE-2.DRUGS OF THE FUTURE. VOL. 30. ISSUE 5. P. 497-508 63 82% 11
8 ZHANG, PT , YANG, XY , ZHANG, FR , GABELLI, SB , WANG, RX , ZHANG, YH , BHAT, S , CHEN, XC , FURLANI, M , AMZEL, LM , ET AL (2013) PYRIDINYLPYRIMIDINES SELECTIVELY INHIBIT HUMAN METHIONINE AMINOPEPTIDASE-1.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 21. ISSUE 9. P. 2600 -2617 47 85% 2
9 KRUGER, EA , FIGG, WD , (2000) TNP-470: AN ANGIOGENESIS INHIBITOR IN CLINICAL DEVELOPMENT FOR CANCER.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 9. ISSUE 6. P. 1383 -1396 63 80% 89
10 EHLERS, T , FURNESS, S , ROBINSON, TP , ZHONG, HZA , GOLDSMITH, D , ARIBSER, J , BOWEN, JP , (2016) METHIONINE AMINOPEPTIDASE TYPE-2 INHIBITORS TARGETING ANGIOGENESIS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 13. P. 1478 -1488 39 76% 3

Classes with closest relation at Level 1


Rank Class id link
1 23535 PEPTIDE DEFORMYLASE//PEPTIDE DEFORMYLASE INHIBITORS//DEFORMYLASE
2 17545 AMINOPEPTIDASE//LEUCINE AMINOPEPTIDASE//PROLYL AMINOPEPTIDASE
3 24531 DUBLIN MED//2D GEL CLECTROPHORESIS//ANGIOGENIC ACTIVATOR
4 35959 CARBOXYAMIDOTRIAZOLE//PROOFREADING STIMULATION//EQUIMOLAR COMBINATIONS OF NUCLEOTIDES PRECURSORS
5 33389 PENTOSAN POLYSULFATE//ELMIRON//LASER ANIMAL MODEL
6 5798 ENDOSTATIN//ANGIOSTATIN//COLLAGEN XVIII
7 26617 CHONDROMODULIN I//SHARK CARTILAGE//LECT2
8 20056 CHORIOALLANTOIC MEMBRANE//INTUSSUSCEPTIVE MICROVASCULAR GROWTH//INTUSSUSCEPTIVE ANGIOGENESIS
9 6121 MICROVESSEL DENSITY//ANGIOGENESIS//MICROVESSEL COUNT
10 18393 PROLIDASE//PROLIDASE DEFICIENCY//PROLIDASE ACTIVITY

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