Class information for:
Level 1: ENTACAPONE//TOLCAPONE//COMT INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13868 808 31.8 68%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
124 3       PARKINSONS DISEASE//MOVEMENT DISORDERS//DEEP BRAIN STIMULATION 67777
166 2             PARKINSONS DISEASE//MOVEMENT DISORDERS//MULTIPLE SYSTEM ATROPHY 22593
13868 1                   ENTACAPONE//TOLCAPONE//COMT INHIBITORS 808

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ENTACAPONE authKW 3796920 18% 68% 148
2 TOLCAPONE authKW 2251056 11% 68% 88
3 COMT INHIBITORS authKW 1234282 7% 62% 53
4 COMT INHIBITION authKW 1091353 5% 76% 38
5 CATECHOL O METHYLTRANSFERASE authKW 710759 13% 17% 108
6 CATECHOL O METHYLTRANSFERASE INHIBITOR authKW 531418 2% 94% 15
7 OPICAPONE authKW 377899 1% 100% 10
8 NEBICAPONE authKW 343542 1% 91% 10
9 STALEVO authKW 302311 1% 67% 12
10 CATECHOL O METHYLTRANSFERASE INHIBITORS authKW 254023 1% 61% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Clinical Neurology 3026 27% 0% 221
2 Pharmacology & Pharmacy 2488 33% 0% 270
3 Neurosciences 812 20% 0% 164
4 Chemistry, Analytical 544 12% 0% 100
5 Biochemical Research Methods 490 9% 0% 73
6 Chemistry, Medicinal 289 6% 0% 51
7 Biochemistry & Molecular Biology 128 15% 0% 120
8 Psychiatry 54 4% 0% 33
9 Toxicology 38 3% 0% 23
10 Chemistry, Multidisciplinary 17 6% 0% 51

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INVEST DESENVOLVIMENTO 132258 1% 50% 7
2 PRAKLIN FOR 68013 1% 30% 6
3 ORION 62976 1% 33% 5
4 AVANZATO BIOTECNOL 37790 0% 100% 1
5 BU NEUROL 37790 0% 100% 1
6 CALIF PARKINSON 37790 0% 100% 1
7 CANC BIOL SCI 37790 0% 100% 1
8 CANC CELL BIOLPROTE SECT DNR 37790 0% 100% 1
9 CHEM BIOL RUTGERS 37790 0% 100% 1
10 CLIN INVEST U825 37790 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLINICAL NEUROPHARMACOLOGY 17161 4% 1% 33
2 JOURNAL OF NEURAL TRANSMISSION 7763 4% 1% 29
3 AKTUELLE NEUROLOGIE 4124 2% 1% 14
4 BIOMEDICAL CHROMATOGRAPHY 2727 2% 0% 16
5 PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION 1650 1% 1% 5
6 EUROPEAN JOURNAL OF NEUROLOGY 1631 2% 0% 13
7 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 1519 2% 0% 17
8 JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION 1512 0% 1% 3
9 MOVEMENT DISORDERS 1459 2% 0% 16
10 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT 1441 0% 1% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ENTACAPONE 3796920 18% 68% 148 Search ENTACAPONE Search ENTACAPONE
2 TOLCAPONE 2251056 11% 68% 88 Search TOLCAPONE Search TOLCAPONE
3 COMT INHIBITORS 1234282 7% 62% 53 Search COMT+INHIBITORS Search COMT+INHIBITORS
4 COMT INHIBITION 1091353 5% 76% 38 Search COMT+INHIBITION Search COMT+INHIBITION
5 CATECHOL O METHYLTRANSFERASE 710759 13% 17% 108 Search CATECHOL+O+METHYLTRANSFERASE Search CATECHOL+O+METHYLTRANSFERASE
6 CATECHOL O METHYLTRANSFERASE INHIBITOR 531418 2% 94% 15 Search CATECHOL+O+METHYLTRANSFERASE+INHIBITOR Search CATECHOL+O+METHYLTRANSFERASE+INHIBITOR
7 OPICAPONE 377899 1% 100% 10 Search OPICAPONE Search OPICAPONE
8 NEBICAPONE 343542 1% 91% 10 Search NEBICAPONE Search NEBICAPONE
9 STALEVO 302311 1% 67% 12 Search STALEVO Search STALEVO
10 CATECHOL O METHYLTRANSFERASE INHIBITORS 254023 1% 61% 11 Search CATECHOL+O+METHYLTRANSFERASE+INHIBITORS Search CATECHOL+O+METHYLTRANSFERASE+INHIBITORS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MANNISTO, PT , KAAKKOLA, S , (1999) CATECHOL-O-METHYLTRANSFERASE (COMT): BIOCHEMISTRY, MOLECULAR BIOLOGY, PHARMACOLOGY, AND CLINICAL EFFICACY OF THE NEW SELECTIVE COMT INHIBITORS.PHARMACOLOGICAL REVIEWS. VOL. 51. ISSUE 4. P. 593 -628 146 50% 612
2 BONIFACIO, MJ , PALMA, PN , ALMEIDA, L , SOARES-DA-SILVA, P , (2007) CATECHOL-O-METHYLTRANSFERASE AND ITS INHIBITORS IN PARKINSON'S DISEASE.CNS DRUG REVIEWS. VOL. 13. ISSUE 3. P. 352 -379 105 68% 59
3 BONIFATI, V , MECO, G , (1999) NEW, SELECTIVE CATECHOL-O-METHYLTRANSFERASE INHIBITORS AS THERAPEUTIC AGENTS IN PARKINSON'S DISEASE.PHARMACOLOGY & THERAPEUTICS. VOL. 81. ISSUE 1. P. 1 -36 131 58% 74
4 NISSINEN, E , MANNISTO, PT , (2010) BIOCHEMISTRY AND PHARMACOLOGY OF CATECHOL O-METHYLTRANSFERASE INHIBITORS.BASIC ASPECTS OF CATECHOL-O-METHYLTRANSTERASE AND THE CLINICAL APPLICATIONS OF ITS INHIBITORS. VOL. 95. ISSUE . P. 73 -118 88 65% 7
5 KISS, LE , SOARES-DA-SILVA, P , (2014) MEDICINAL CHEMISTRY OF CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITORS AND THEIR THERAPEUTIC UTILITY.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 21. P. 8692 -8717 67 66% 9
6 MARSALA, SZ , GIOULIS, M , CERAVOLO, R , TINAZZI, M , (2012) A SYSTEMATIC REVIEW OF CATECHOL-O-METHYLTRANSFERASE INHIBITORS: EFFICACY AND SAFETY IN CLINICAL PRACTICE.CLINICAL NEUROPHARMACOLOGY. VOL. 35. ISSUE 4. P. 185 -190 44 90% 28
7 LEARMONTH, DA , KISS, LE , SOARES-DA SILVA, P , (2010) THE CHEMISTRY OF CATECHOL O-METHYLTRANSFERASE INHIBITORS.BASIC ASPECTS OF CATECHOL-O-METHYLTRANSTERASE AND THE CLINICAL APPLICATIONS OF ITS INHIBITORS. VOL. 95. ISSUE . P. 119 -162 53 85% 7
8 HAASIO, K , (2010) TOXICOLOGY AND SAFETY OF COMT INHIBITORS.BASIC ASPECTS OF CATECHOL-O-METHYLTRANSTERASE AND THE CLINICAL APPLICATIONS OF ITS INHIBITORS. VOL. 95. ISSUE . P. 163 -189 55 75% 17
9 BARROW, JC , (2012) INHIBITORS OF CATECHOL-O-METHYLTRANSFERASE.CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. VOL. 11. ISSUE 3. P. 324-332 52 78% 3
10 TERAVAINEN, H , RINNE, U , GORDIN, A , (2001) CATECHOL-O-METHYLTRANSFERASE INHIBITORS IN PARKINSON'S DISEASE.PARKINSON'S DISEASE. VOL. 86. ISSUE . P. 311 -325 75 74% 2

Classes with closest relation at Level 1


Rank Class id link
1 10637 COMT//CATECHOL O METHYLTRANSFERASE//COMT VAL158MET
2 372 DYSKINESIA//LEVODOPA//MOTOR FLUCTUATIONS
3 14695 METHYLDOPA//CARBIDOPA//LEVODOPA
4 21282 DOPAMINE 4 O SULFATE//CONJUGATED NORADRENALINE//CATECHOLAMINE SULFATE
5 8489 I 123 FP CIT//VASCULAR PARKINSONISM//DOPAMINE TRANSPORTER
6 18845 UPTAKE1//CARDIAC PHYSIOL//NON EXOCYTOTIC RELEASE
7 7937 SELEGILINE//RASAGILINE//DEPRENYL
8 17072 VISUAL HALLUCINATIONS//HALLUCINATIONS//PARKINSONS DISEASE PSYCHOSIS
9 3801 NON MOTOR SYMPTOMS//PARKINSONS DISEASE//PDQ 39
10 33185 MED HOSP PHARM YAHATANISHI KU//THERMOPHYSIOL//BEN METABOLISM

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