Class information for:
Level 1: DGAT 1 INHIBITOR//MONOACYLGLYCEROL ACYLTRANSFERASE//DGAT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17349 604 40.2 80%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
1628 2             LIPID DROPLETS//CARDIOLIPIN//PERILIPIN 7008
17349 1                   DGAT 1 INHIBITOR//MONOACYLGLYCEROL ACYLTRANSFERASE//DGAT 604

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DGAT 1 INHIBITOR authKW 610257 2% 93% 13
2 MONOACYLGLYCEROL ACYLTRANSFERASE authKW 323542 1% 80% 8
3 DGAT authKW 320150 3% 33% 19
4 PRADIGASTAT authKW 294128 1% 73% 8
5 DIACYLGLYCEROL ACYLTRANSFERASE authKW 267725 4% 21% 25
6 ACYL COA DIACYLGLYCEROL ACYLTRANSFERASE authKW 231097 1% 57% 8
7 LIPID SIGNALING address 226544 2% 41% 11
8 MGAT authKW 210640 1% 83% 5
9 DGAT1 authKW 206395 3% 19% 21
10 GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE authKW 173311 2% 29% 12

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 2679 55% 0% 332
2 Chemistry, Medicinal 885 12% 0% 72
3 Biophysics 597 12% 0% 74
4 Nutrition & Dietetics 267 6% 0% 37
5 Endocrinology & Metabolism 227 9% 0% 52
6 Cell Biology 197 11% 0% 67
7 Pharmacology & Pharmacy 148 12% 0% 70
8 Physiology 49 4% 0% 25
9 Chemistry, Organic 38 5% 0% 32
10 Genetics & Heredity 31 4% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LIPID SIGNALING 226544 2% 41% 11
2 BIOINFORMAT CORE SCI 101108 0% 100% 2
3 CARDIOVASC GASTROINTESTINAL INNOVAT MED UNIT MO 101108 0% 100% 2
4 FIBROSIS DISCOVERY 101108 0% 100% 2
5 CARDIOVASC METAB ENDOCRINE DIS UNIT 54942 1% 22% 5
6 AMGEN S SAN FRANCISCO 50554 0% 100% 1
7 BIOL INFORMAT SIGNAL 50554 0% 100% 1
8 CARDIOVASC DIABET DISCOVERY 50554 0% 100% 1
9 CCT LA PLATA INVEST BIOQUIM LA PLATA 50554 0% 100% 1
10 CNRS EQUIPE RECH ELLISEE ERL 50554 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF LIPID RESEARCH 16667 9% 1% 53
2 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 9097 4% 1% 22
3 JOURNAL OF ANTIBIOTICS 2172 3% 0% 17
4 JOURNAL OF BIOLOGICAL CHEMISTRY 1856 13% 0% 76
5 AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 1296 2% 0% 13
6 LIPIDS 1217 2% 0% 12
7 PROGRESS IN LIPID RESEARCH 1032 1% 1% 4
8 MEDCHEMCOMM 928 1% 0% 5
9 ACS MEDICINAL CHEMISTRY LETTERS 911 1% 0% 5
10 CELL METABOLISM 860 1% 0% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DGAT 1 INHIBITOR 610257 2% 93% 13 Search DGAT+1+INHIBITOR Search DGAT+1+INHIBITOR
2 MONOACYLGLYCEROL ACYLTRANSFERASE 323542 1% 80% 8 Search MONOACYLGLYCEROL+ACYLTRANSFERASE Search MONOACYLGLYCEROL+ACYLTRANSFERASE
3 DGAT 320150 3% 33% 19 Search DGAT Search DGAT
4 PRADIGASTAT 294128 1% 73% 8 Search PRADIGASTAT Search PRADIGASTAT
5 DIACYLGLYCEROL ACYLTRANSFERASE 267725 4% 21% 25 Search DIACYLGLYCEROL+ACYLTRANSFERASE Search DIACYLGLYCEROL+ACYLTRANSFERASE
6 ACYL COA DIACYLGLYCEROL ACYLTRANSFERASE 231097 1% 57% 8 Search ACYL+COA+DIACYLGLYCEROL+ACYLTRANSFERASE Search ACYL+COA+DIACYLGLYCEROL+ACYLTRANSFERASE
7 MGAT 210640 1% 83% 5 Search MGAT Search MGAT
8 DGAT1 206395 3% 19% 21 Search DGAT1 Search DGAT1
9 GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE 173311 2% 29% 12 Search GLYCEROL+3+PHOSPHATE+ACYLTRANSFERASE Search GLYCEROL+3+PHOSPHATE+ACYLTRANSFERASE
10 DGAT2 157483 1% 35% 9 Search DGAT2 Search DGAT2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 YEN, CLE , NELSON, DW , YEN, MI , (2015) THEMATIC REVIEW SERIES: INTESTINAL LIPID METABOLISM: NEW DEVELOPMENTS AND CURRENT INSIGHTS INTESTINAL TRIACYLGLYCEROL SYNTHESIS IN FAT ABSORPTION AND SYSTEMIC ENERGY METABOLISM.JOURNAL OF LIPID RESEARCH. VOL. 56. ISSUE 3. P. 489 -501 68 50% 12
2 NAIK, R , OBIANG-OBOUNOU, BW , KIM, M , CHOI, Y , LEE, HS , LEE, K , (2014) THERAPEUTIC STRATEGIES FOR METABOLIC DISEASES: SMALL-MOLECULE DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) INHIBITORS.CHEMMEDCHEM. VOL. 9. ISSUE 11. P. 2410 -2424 62 64% 7
3 GIMENO, RE , CAO, J , (2008) THEMATIC REVIEW SERIES: GLYCEROLIPIDS - MAMMALIAN GLYCEROL-3-PHOSPHATE ACYLTRANSFERASES: NEW GENES FOR AN OLD ACTIVITY.JOURNAL OF LIPID RESEARCH. VOL. 49. ISSUE 10. P. 2079-2088 50 61% 60
4 YEN, CLE , STONE, SJ , KOLIWAD, S , HARRIS, C , FARESE, RV , (2008) DGAT ENZYMES AND TRIACYLGLYCEROL BIOSYNTHESIS.JOURNAL OF LIPID RESEARCH. VOL. 49. ISSUE 11. P. 2283-2301 58 37% 303
5 FOX, BM , SUGIMOTO, K , IIO, K , YOSHIDA, A , ZHANG, J , LI, KX , HAO, XL , LABELLE, M , SMITH, ML , RUBENSTEIN, SM , ET AL (2014) DISCOVERY OF 6-PHENYLPYRIMIDO[4,5-B][1,4]OXAZINES AS POTENT AND SELECTIVE ACYL COA:DIACYLGLYCEROL ACYLTRANSFERASE 1 (DGAT1) INHIBITORS WITH IN VIVO EFFICACY IN RODENTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 8. P. 3464 -3483 36 75% 8
6 COLEMAN, RA , MASHEK, DG , (2011) MAMMALIAN TRIACYLGLYCEROL METABOLISM: SYNTHESIS, LIPOLYSIS, AND SIGNALING.CHEMICAL REVIEWS. VOL. 111. ISSUE 10. P. 6359 -6386 100 24% 55
7 WENDEL, AA , LEWIN, TM , COLEMAN, RA , (2009) GLYCEROL-3-PHOSPHATE ACYLTRANSFERASES: RATE LIMITING ENZYMES OF TRIACYLGLYCEROL BIOSYNTHESIS.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1791. ISSUE 6. P. 501 -506 40 60% 81
8 ZHANG, J , XU, D , NIE, J , CAO, JS , ZHAI, YG , TONG, DW , SHI, YG , (2014) MONOACYLGLYCEROL ACYLTRANSFERASE-2 IS A TETRAMERIC ENZYME THAT SELECTIVELY HETERODIMERIZES WITH DIACYLGLYCEROL ACYLTRANSFERASE-1.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 289. ISSUE 15. P. 10909 -10918 28 85% 5
9 BIRCH, AM , BUCKETT, LK , TURNBULL, AV , (2010) DGAT1 INHIBITORS AS ANTI-OBESITY AND ANTI-DIABETIC AGENTS.CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. VOL. 13. ISSUE 4. P. 489-496 26 81% 60
10 YAMASHITA, A , HAYASHI, Y , NEMOTO-SASAKI, Y , ITO, M , OKA, S , TANIKAWA, T , WAKU, K , SUGIURA, T , (2014) ACYLTRANSFERASES AND TRANSACYLASES THAT DETERMINE THE FATTY ACID COMPOSITION OF GLYCEROLIPIDS AND THE METABOLISM OF BIOACTIVE LIPID MEDIATORS IN MAMMALIAN CELLS AND MODEL ORGANISMS.PROGRESS IN LIPID RESEARCH. VOL. 53. ISSUE . P. 18-81 100 17% 24

Classes with closest relation at Level 1


Rank Class id link
1 24863 PHOSPHATIDATE PHOSPHOHYDROLASE//MED BIOCHEM 328 HERITAGE MED//MED LIPID LIPOPROT GRP
2 14071 RUTGERS LIPID//LIPIN//LIPIN 1
3 30893 LIPID ABSORPTION//ABSORPTION LYMPH AND BLOOD//ACYLGLYCEROL ACYLTRANSFERASE
4 17286 SEIPIN//CONGENITAL GENERALIZED LIPODYSTROPHY//BSCL2
5 3701 LIPID DROPLETS//PERILIPIN//ADIPOSE TRIGLYCERIDE LIPASE
6 2399 FAD2//FATTY ACID DESATURASE//DESATURASE
7 11049 ACYL TURNOVER//ARACHIDONATE MOVEMENT//EICOSANOID PRECURSOR
8 12318 ACAT INHIBITOR//ACYL COA CHOLESTEROL ACYLTRANSFERASE//ACAT
9 3142 MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN//APOLIPOPROTEIN B//HYPOBETALIPOPROTEINEMIA
10 7435 CD36//FAT CD36//ACYL COA SYNTHETASE

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