Class information for:
Level 1: CENTRAL HYPOTHYROIDISM//IGSF1//ISOLATED TSH DEFICIENCY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
24158 321 28.1 54%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
139 3       THYROID//THYROID CANCER//GRAVES DISEASE 64904
856 2             HYPOTHYROIDISM//SUBCLINICAL HYPOTHYROIDISM//HYPERTHYROIDISM 11613
24158 1                   CENTRAL HYPOTHYROIDISM//IGSF1//ISOLATED TSH DEFICIENCY 321

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CENTRAL HYPOTHYROIDISM authKW 610894 5% 38% 17
2 IGSF1 authKW 396353 2% 83% 5
3 ISOLATED TSH DEFICIENCY authKW 285376 1% 100% 3
4 IMMUNOGLOBULIN SUPERFAMILY MEMBER 1 authKW 190250 1% 100% 2
5 TSH BETA GENE authKW 190250 1% 100% 2
6 ACTIVITY VERSUS REST authKW 95125 0% 100% 1
7 AFRICAN MELANOID authKW 95125 0% 100% 1
8 ARRAY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS authKW 95125 0% 100% 1
9 BIOCYCLES authKW 95125 0% 100% 1
10 CAM MOLECULES authKW 95125 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Endocrinology & Metabolism 9942 67% 0% 215
2 Medicine, General & Internal 163 12% 0% 38
3 Pediatrics 152 8% 0% 27
4 Physiology 11 3% 0% 10
5 Medicine, Research & Experimental 8 3% 0% 10
6 Medical Laboratory Technology 5 1% 0% 3
7 Biology 5 2% 0% 6
8 Primary Health Care 1 0% 0% 1
9 Genetics & Heredity 1 2% 0% 7
10 Urology & Nephrology 0 1% 0% 3

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CATTEDRA ENDOCRINOL VIA S GIORGIO 12 95125 0% 100% 1
2 CHILDRENS HOSP SAN JOAO 95125 0% 100% 1
3 CHRONOENDOCRINOL 95125 0% 100% 1
4 ENDOCRINOL DIABET NUTRI 95125 0% 100% 1
5 ENODCRINE SCI 95125 0% 100% 1
6 HOP ST JUSTINE UNIT BIOL REPROD DEV 95125 0% 100% 1
7 HS RAFFAELE IST RICOVERO CURA CARATTERE SCI 95125 0% 100% 1
8 IC4 WALTER MACKENZIE HLTH SCI 95125 0% 100% 1
9 INRS PHYSIOL PSYCHOL ENVIRONM 95125 0% 100% 1
10 INVEST MED MOL ENFERMEDADES CRONICAS CIMUS 95125 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 19206 21% 0% 69
2 ACTA ENDOCRINOLOGICA 16445 8% 1% 26
3 THYROID 4357 4% 0% 13
4 PITUITARY 2227 1% 1% 4
5 CLINICAL ENDOCRINOLOGY 2132 4% 0% 13
6 HORMONE RESEARCH 1740 2% 0% 8
7 JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 1553 3% 0% 9
8 ENDOCRINOLOGIA JAPONICA 1075 1% 0% 4
9 PADIATRIE UND PADOLOGIE 1067 0% 1% 1
10 HORMONE AND METABOLIC RESEARCH 952 2% 0% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CENTRAL HYPOTHYROIDISM 610894 5% 38% 17 Search CENTRAL+HYPOTHYROIDISM Search CENTRAL+HYPOTHYROIDISM
2 IGSF1 396353 2% 83% 5 Search IGSF1 Search IGSF1
3 ISOLATED TSH DEFICIENCY 285376 1% 100% 3 Search ISOLATED+TSH+DEFICIENCY Search ISOLATED+TSH+DEFICIENCY
4 IMMUNOGLOBULIN SUPERFAMILY MEMBER 1 190250 1% 100% 2 Search IMMUNOGLOBULIN+SUPERFAMILY+MEMBER+1 Search IMMUNOGLOBULIN+SUPERFAMILY+MEMBER+1
5 TSH BETA GENE 190250 1% 100% 2 Search TSH+BETA+GENE Search TSH+BETA+GENE
6 ACTIVITY VERSUS REST 95125 0% 100% 1 Search ACTIVITY+VERSUS+REST Search ACTIVITY+VERSUS+REST
7 AFRICAN MELANOID 95125 0% 100% 1 Search AFRICAN+MELANOID Search AFRICAN+MELANOID
8 ARRAY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS 95125 0% 100% 1 Search ARRAY+COMPARATIVE+GENOMIC+HYBRIDIZATION+ANALYSIS Search ARRAY+COMPARATIVE+GENOMIC+HYBRIDIZATION+ANALYSIS
9 BIOCYCLES 95125 0% 100% 1 Search BIOCYCLES Search BIOCYCLES
10 CAM MOLECULES 95125 0% 100% 1 Search CAM+MOLECULES Search CAM+MOLECULES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PAPPA, T , JOHANNESEN, J , SCHERBERG, N , TORRENT, M , DUMITRESCU, A , REFETOFF, S , (2015) A TSH BETA VARIANT WITH IMPAIRED IMMUNOREACTIVITY BUT INTACT BIOLOGICAL ACTIVITY AND ITS CLINICAL IMPLICATIONS.THYROID. VOL. 25. ISSUE 8. P. 869 -876 24 86% 2
2 HERMANNS, P , COUCH, R , LEONARD, N , KLOTZ, C , POHLENZ, J , (2014) A NOVEL DELETION IN THE THYROTROPIN BETA-SUBUNIT GENE IDENTIFIED BY ARRAY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS CAUSES CENTRAL CONGENITAL HYPOTHYROIDISM IN A BOY ORIGINATING FROM TURKEY.HORMONE RESEARCH IN PAEDIATRICS. VOL. 82. ISSUE 3. P. 201 -205 23 79% 3
3 TENENBAUM-RAKOVER, Y , TURGEON, MO , LONDON, S , HERMANNS, P , POHLENZ, J , BERNARD, DJ , BERCOVICH, D , (2016) FAMILIAL CENTRAL HYPOTHYROIDISM CAUSED BY A NOVEL IGSF1 GENE MUTATION.THYROID. VOL. 26. ISSUE 12. P. 1693 -1700 15 68% 1
4 ROELFSEMA, F , VELDHUIS, JD , (2013) THYROTROPIN SECRETION PATTERNS IN HEALTH AND DISEASE.ENDOCRINE REVIEWS. VOL. 34. ISSUE 5. P. 619 -657 58 18% 15
5 GOICHOT, B , BRANDENBERGER, G , (1996) RHYTHMIC THYROTROPIN SECRETION - PHYSIOLOGICAL DATA AND CLINICAL APPLICATIONS.PRESSE MEDICALE. VOL. 25. ISSUE 21. P. 980-984 20 95% 1
6 BAQUEDANO, MS , CIACCIO, M , DUJOVNE, N , HERZOVICH, V , LONGUEIRA, Y , WARMAN, DM , RIVAROLA, MA , BELGOROSKY, A , (2010) TWO NOVEL MUTATIONS OF THE TSH-BETA SUBUNIT GENE UNDERLYING CONGENITAL CENTRAL HYPOTHYROIDISM UNDETECTABLE IN NEONATAL TSH SCREENING.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. VOL. 95. ISSUE 9. P. E98 -E103 17 68% 12
7 PARTSCH, CJ , RIEPE, FG , KRONE, N , SIPPELL, WG , POHLENZ, J , (2006) INITIALLY ELEVATED TSH AND CONGENITAL CENTRAL HYPOTHYROIDISM DUE TO A HOMOZYGOUS MUTATION OF THE TSH BETA SUBUNIT GENE: CASE REPORT AND REVIEW OF THE LITERATURE.EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES. VOL. 114. ISSUE 5. P. 227-234 20 65% 9
8 SCHOENMAKERS, N , ALATZOGLOU, KS , CHATTERJEE, VK , DATTANI, MT , (2015) RECENT ADVANCES IN CENTRAL CONGENITAL HYPOTHYROIDISM.JOURNAL OF ENDOCRINOLOGY. VOL. 227. ISSUE 3. P. R51 -R71 35 27% 5
9 NISHIGAKI, S , HAMAZAKI, T , FUJITA, K , MORIKAWA, S , TAJIMA, T , SHINTAKU, H , (2016) A JAPANESE FAMILY WITH CENTRAL HYPOTHYROIDISM CAUSED BY A NOVEL IGSF1 MUTATION.THYROID. VOL. 26. ISSUE 12. P. 1701 -1705 14 67% 0
10 MACCAGNAN, P , OLIVEIRA, JHA , CASTRO, V , ABUCHAM, J , (1999) ABNORMAL CIRCADIAN RHYTHM AND INCREASED NON-PULSATILE SECRETION OF THYROTROPHIN IN SHEEHAN'S SYNDROME.CLINICAL ENDOCRINOLOGY. VOL. 51. ISSUE 4. P. 439-447 17 68% 8

Classes with closest relation at Level 1


Rank Class id link
1 4081 NONTHYROIDAL ILLNESS//EUTHYROID SICK SYNDROME//THYROXINE BINDING GLOBULIN
2 17461 LEVOTHYROXINE//PSEUDOMALABSORPTION//LIOTHYRONINE
3 8942 HYPOTHALAMIC AMENORRHEA//MAYO MED EDUC//PULSATILE GNRH
4 3900 GLYCOPROTEIN HORMONE//FSH ISOFORMS//ROBERT WOOD JOHNSON RUTGERS MED
5 7603 CONGENITAL HYPOTHYROIDISM//NEONATAL SCREENING//PRIMARY CONGENITAL HYPOTHYROIDISM
6 15460 PITUITARY HYPERPLASIA//PRIMARY HYPOTHYROIDISM//VAN WYK AND GRUMBACH SYNDROME
7 6926 TRH TEST//HLTH UZICE//HYPOTHYROIDISM
8 11080 LYMPHOCYTIC HYPOPHYSITIS//SHEEHANS SYNDROME//HYPOPHYSITIS
9 33665 AMENORRHEA BROMOCRIPTINE//ANTIREPRODUCTION//GALACTORRHEA HYPERPROLACTINEMIA PROLACTIN
10 2161 THYROTROPIN RELEASING HORMONE//TRH//TRH RECEPTOR

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