Class information for:
Level 1: TETRAHYDROBIOPTERIN//GTP CYCLOHYDROLASE I//SEPIAPTERIN REDUCTASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4393 1793 35.3 68%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
124 3       PARKINSONS DISEASE//MOVEMENT DISORDERS//DEEP BRAIN STIMULATION 67777
1818 2             DYSTONIA//TETRAHYDROBIOPTERIN//WRITERS CRAMP 6225
4393 1                   TETRAHYDROBIOPTERIN//GTP CYCLOHYDROLASE I//SEPIAPTERIN REDUCTASE 1793

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TETRAHYDROBIOPTERIN authKW 3528764 23% 50% 414
2 GTP CYCLOHYDROLASE I authKW 1127653 6% 66% 100
3 SEPIAPTERIN REDUCTASE authKW 463540 2% 78% 35
4 BIOPTERIN authKW 393153 3% 42% 55
5 PTERIDINES journal 304399 5% 21% 85
6 SEPIAPTERIN authKW 231344 1% 54% 25
7 DIHYDROPTERIDINE REDUCTASE authKW 211963 1% 66% 19
8 DIHYDROBIOPTERIN authKW 191852 1% 87% 13
9 TETRAHYDROBIOPTERIN DEFICIENCY authKW 182440 1% 71% 15
10 PTERIN GLYCOSIDE authKW 153257 1% 100% 9

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 4184 41% 0% 742
2 Biophysics 2400 14% 0% 252
3 Peripheral Vascular Diseases 764 7% 0% 121
4 Medicine, Research & Experimental 707 8% 0% 152
5 Genetics & Heredity 573 9% 0% 157
6 Endocrinology & Metabolism 551 8% 0% 142
7 Cardiac & Cardiovascular System 403 7% 0% 128
8 Neurosciences 328 10% 0% 186
9 Pharmacology & Pharmacy 190 9% 0% 155
10 Pediatrics 150 4% 0% 75

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLIN CHEM BIOCHEM 41606 2% 6% 38
2 REDOX BIOL PROGRAM 34757 0% 29% 7
3 MELATONIN CLIN 34057 0% 100% 2
4 PTERIDINE BIOCHEM 34057 0% 100% 2
5 STRUKT FOR ABT 22703 0% 67% 2
6 CHILDHOOD INFECT GRP 21890 0% 43% 3
7 CREAT INITIAT GENET REPROGRAMMING 21278 0% 25% 5
8 ANESTHESIOLDAVID GEFFEN MED 17029 0% 100% 1
9 AUHUI PROV POPULAT HLTH EUGEN 17029 0% 100% 1
10 AUTON UNIT HOSP NEUROL NEUROSURG MED 17029 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PTERIDINES 304399 5% 21% 85
2 JOURNAL OF INHERITED METABOLIC DISEASE 17318 4% 2% 68
3 MOLECULAR GENETICS AND METABOLISM 2848 1% 1% 23
4 JOURNAL OF NEUROCHEMISTRY 1888 3% 0% 49
5 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 1185 2% 0% 30
6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1132 4% 0% 70
7 ARCHIVES FRANCAISES DE PEDIATRIE 919 1% 1% 10
8 HELVETICA CHIMICA ACTA 827 1% 0% 21
9 FREE RADICAL BIOLOGY AND MEDICINE 758 1% 0% 20
10 JOURNAL OF BIOLOGICAL CHEMISTRY 738 5% 0% 88

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TETRAHYDROBIOPTERIN 3528764 23% 50% 414 Search TETRAHYDROBIOPTERIN Search TETRAHYDROBIOPTERIN
2 GTP CYCLOHYDROLASE I 1127653 6% 66% 100 Search GTP+CYCLOHYDROLASE+I Search GTP+CYCLOHYDROLASE+I
3 SEPIAPTERIN REDUCTASE 463540 2% 78% 35 Search SEPIAPTERIN+REDUCTASE Search SEPIAPTERIN+REDUCTASE
4 BIOPTERIN 393153 3% 42% 55 Search BIOPTERIN Search BIOPTERIN
5 SEPIAPTERIN 231344 1% 54% 25 Search SEPIAPTERIN Search SEPIAPTERIN
6 DIHYDROPTERIDINE REDUCTASE 211963 1% 66% 19 Search DIHYDROPTERIDINE+REDUCTASE Search DIHYDROPTERIDINE+REDUCTASE
7 DIHYDROBIOPTERIN 191852 1% 87% 13 Search DIHYDROBIOPTERIN Search DIHYDROBIOPTERIN
8 TETRAHYDROBIOPTERIN DEFICIENCY 182440 1% 71% 15 Search TETRAHYDROBIOPTERIN+DEFICIENCY Search TETRAHYDROBIOPTERIN+DEFICIENCY
9 PTERIN GLYCOSIDE 153257 1% 100% 9 Search PTERIN+GLYCOSIDE Search PTERIN+GLYCOSIDE
10 6 PYRUVOYL TETRAHYDROPTERIN SYNTHASE 153251 1% 75% 12 Search 6+PYRUVOYL+TETRAHYDROPTERIN+SYNTHASE Search 6+PYRUVOYL+TETRAHYDROPTERIN+SYNTHASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WERNER, ER , BLAU, N , THOENY, B , (2011) TETRAHYDROBIOPTERIN: BIOCHEMISTRY AND PATHOPHYSIOLOGY.BIOCHEMICAL JOURNAL. VOL. 438. ISSUE . P. 397-414 130 63% 98
2 BENDALL, JK , DOUGLAS, G , MCNEILL, E , CHANNON, KM , CRABTREE, MJ , (2014) TETRAHYDROBIOPTERIN IN CARDIOVASCULAR HEALTH AND DISEASE.ANTIOXIDANTS & REDOX SIGNALING. VOL. 20. ISSUE 18. P. 3040 -3077 149 48% 23
3 THONY, B , AUERBACH, G , BLAU, N , (2000) TETRAHYDROBIOPTERIN BIOSYNTHESIS, REGENERATION AND FUNCTIONS.BIOCHEMICAL JOURNAL. VOL. 347. ISSUE . P. 1 -16 98 78% 492
4 STARR, A , HUSSEIN, D , NANDI, M , (2013) THE REGULATION OF VASCULAR TETRAHYDROBIOPTERIN BIOAVAILABILITY.VASCULAR PHARMACOLOGY. VOL. 58. ISSUE 3. P. 219-230 106 60% 4
5 PONZONE, A , SPADA, M , FERRARIS, S , DIANZANI, I , DE SANCTIS, L , (2004) DIHYDROPTERIDINE REDUCTASE DEFICIENCY IN MAN: FROM BIOLOGY TO TREATMENT.MEDICINAL RESEARCH REVIEWS. VOL. 24. ISSUE 2. P. 127 -150 82 88% 24
6 CRABTREE, MJ , CHANNON, KM , (2011) SYNTHESIS AND RECYCLING OF TETRAHYDROBIOPTERIN IN ENDOTHELIAL FUNCTION AND VASCULAR DISEASE.NITRIC OXIDE-BIOLOGY AND CHEMISTRY. VOL. 25. ISSUE 2. P. 81-88 63 68% 64
7 WERNER-FELMAYER, G , GOLDERER, G , WERNER, ER , (2002) TETRAHYDROBIOPTERIN BIOSYNTHESIS, UTILIZATION AND PHARMACOLOGICAL EFFECTS.CURRENT DRUG METABOLISM. VOL. 3. ISSUE 2. P. 159 -173 86 67% 95
8 VASQUEZ-VIVAR, J , (2009) TETRAHYDROBIOPTERIN, SUPEROXIDE, AND VASCULAR DYSFUNCTION.FREE RADICAL BIOLOGY AND MEDICINE. VOL. 47. ISSUE 8. P. 1108-1119 65 67% 31
9 KIM, HL , PARK, YS , (2010) MAINTENANCE OF CELLULAR TETRAHYDROBIOPTERIN HOMEOSTASIS.BMB REPORTS. VOL. 43. ISSUE 9. P. 584 -592 57 76% 12
10 KATUSIC, ZS , D'USCIO, LV , NATH, KA , (2009) VASCULAR PROTECTION BY TETRA HYDROBIOPTERIN: PROGRESS AND THERAPEUTIC PROSPECTS.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 30. ISSUE 1. P. 48 -54 52 73% 71

Classes with closest relation at Level 1


Rank Class id link
1 18043 DOPA RESPONSIVE DYSTONIA//CEREBRAL FOLATE DEFICIENCY//SEGAWA DISEASE
2 10585 NEOPTERIN//PTERIDINES//MED CHEM BIOCHEM FRITZ PREGL STR 3
3 9156 PHENYLALANINE HYDROXYLASE//AROMATIC AMINO ACID HYDROXYLASE//TRYPTOPHAN HYDROXYLASE
4 3477 NITRIC OXIDE SYNTHASE//MOL INNOVAT DRUG DISCOVERY//HEME REDUCTION
5 30031 CIENCIAS EXACTASCCT LA PLATACONICET//6 FORMYLPTERIN//QUIMCCT LA PLATA CONICET
6 27111 FLEXIMERS//WHITMANIA PIGRA//1 3 DIMETHYLLUMAZINE 5 OXIDE
7 20641 MOL CARDIOBIOL PROGRAM//CARDIOVASC HYPERTENS//ENDOTHELIAL NITRIC OXIDE SYNTHASE
8 2133 PHENYLKETONURIA//PKU//HYPERPHENYLALANINEMIA
9 31201 HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE
10 20869 ZENTRUM PHARMAKOL//SURG 497 SCAIFE HALL//SKIN XENOGRAFTS

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