Class information for:
Level 1: INTEGRIN ALPHAVBETA3//CILENGITIDE//RGD PEPTIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5042 1683 47.8 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
307 3       INTEGRIN//ALPORT SYNDROME//LAMININ 40384
683 2             INTEGRIN//FOCAL ADHESION KINASE//TENASCIN C 13145
5042 1                   INTEGRIN ALPHAVBETA3//CILENGITIDE//RGD PEPTIDE 1683

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTEGRIN ALPHAVBETA3 authKW 852805 5% 54% 87
2 CILENGITIDE authKW 646348 3% 76% 47
3 RGD PEPTIDE authKW 413756 7% 21% 111
4 ALPHAVBETA3 authKW 376854 3% 48% 43
5 MED ISOTOPES address 310541 3% 40% 43
6 RGD authKW 293568 6% 16% 104
7 INTEGRIN authKW 290580 21% 5% 356
8 TC 99M 3PRGD2 authKW 218994 1% 93% 13
9 ALPHAVBETA3 INTEGRIN authKW 209673 2% 34% 34
10 INTETUMUMAB authKW 146946 1% 90% 9

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 3213 13% 0% 227
2 Oncology 3122 24% 0% 397
3 Radiology, Nuclear Medicine & Medical Imaging 2849 17% 0% 283
4 Chemistry, Organic 799 11% 0% 190
5 Medicine, Research & Experimental 747 9% 0% 150
6 Pharmacology & Pharmacy 490 12% 0% 208
7 Biochemistry & Molecular Biology 419 17% 0% 290
8 Biochemical Research Methods 411 6% 0% 103
9 Cell Biology 338 9% 0% 155
10 Chemistry, Multidisciplinary 109 8% 0% 141

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED ISOTOPES 310541 3% 40% 43
2 INTERDIPARTIMENTALE STUDI BIOMOL PLICAZ I 90708 0% 100% 5
3 CISPIM 72567 0% 100% 4
4 ONCOL PLATFORM 72567 0% 100% 4
5 MOL IMAGING NANOMED 66265 1% 15% 25
6 RADIOL MIPS 58052 0% 80% 4
7 INTER PRECLIN DEV MOL IMAGING CISPIM 56689 0% 63% 5
8 BONE BIOL OSTEOPOROSIS 52987 1% 19% 15
9 RADIOL BIOX 48375 0% 67% 4
10 MIPS 42799 2% 8% 30

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THERANOSTICS 19301 1% 4% 25
2 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 10427 3% 1% 43
3 MOLECULAR IMAGING 10267 1% 4% 16
4 MOLECULAR IMAGING AND BIOLOGY 9952 1% 2% 23
5 BIOCONJUGATE CHEMISTRY 8675 3% 1% 49
6 CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 6542 1% 2% 23
7 JOURNAL OF NUCLEAR MEDICINE 5729 3% 1% 57
8 NUCLEAR MEDICINE AND BIOLOGY 5650 2% 1% 34
9 NATO ADVANCED SCIENCE INSTITUTES SERIES, SERIES A, LIFE SCIENCES 4076 1% 3% 9
10 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3236 4% 0% 68

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 INTEGRIN ALPHAVBETA3 852805 5% 54% 87 Search INTEGRIN+ALPHAVBETA3 Search INTEGRIN+ALPHAVBETA3
2 CILENGITIDE 646348 3% 76% 47 Search CILENGITIDE Search CILENGITIDE
3 RGD PEPTIDE 413756 7% 21% 111 Search RGD+PEPTIDE Search RGD+PEPTIDE
4 ALPHAVBETA3 376854 3% 48% 43 Search ALPHAVBETA3 Search ALPHAVBETA3
5 RGD 293568 6% 16% 104 Search RGD Search RGD
6 INTEGRIN 290580 21% 5% 356 Search INTEGRIN Search INTEGRIN
7 TC 99M 3PRGD2 218994 1% 93% 13 Search TC+99M+3PRGD2 Search TC+99M+3PRGD2
8 ALPHAVBETA3 INTEGRIN 209673 2% 34% 34 Search ALPHAVBETA3+INTEGRIN Search ALPHAVBETA3+INTEGRIN
9 INTETUMUMAB 146946 1% 90% 9 Search INTETUMUMAB Search INTETUMUMAB
10 ALPHAVBETA3 ANTAGONISTS 126992 0% 100% 7 Search ALPHAVBETA3+ANTAGONISTS Search ALPHAVBETA3+ANTAGONISTS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DESGROSELLIER, JS , CHERESH, DA , (2010) INTEGRINS IN CANCER: BIOLOGICAL IMPLICATIONS AND THERAPEUTIC OPPORTUNITIES.NATURE REVIEWS CANCER. VOL. 10. ISSUE 1. P. 9 -22 82 44% 1120
2 LIU, S , (2015) RADIOLABELED CYCLIC RGD PEPTIDE BIOCONJUGATES AS RADIOTRACERS TARGETING MULTIPLE INTEGRINS.BIOCONJUGATE CHEMISTRY. VOL. 26. ISSUE 8. P. 1413 -1438 127 59% 10
3 CHEN, HJ , NIU, G , WU, H , CHEN, XY , (2016) CLINICAL APPLICATION OF RADIOLABELED RGD PEPTIDES FOR PET IMAGING OF INTEGRIN ALPHA(V)BETA(3).THERANOSTICS. VOL. 6. ISSUE 1. P. 78 -92 66 74% 10
4 LIU, S , (2009) RADIOLABELED CYCLIC RGD PEPTIDES AS INTEGRIN ALPHA(V)BETA(3)-TARGETED RADIOTRACERS: MAXIMIZING BINDING AFFINITY VIA BIVALENCY.BIOCONJUGATE CHEMISTRY. VOL. 20. ISSUE 12. P. 2199 -2213 85 71% 170
5 LIU, Z , WANG, F , (2013) DEVELOPMENT OF RGD-BASED RADIOTRACERS FOR TUMOR IMAGING AND THERAPY: TRANSLATING FROM BENCH TO BEDSIDE.CURRENT MOLECULAR MEDICINE. VOL. 13. ISSUE 10. P. 1487 -1505 75 72% 19
6 AUZZAS, L , ZANARDI, F , BATTISTINI, L , BURREDDU, P , CARTA, P , RASSU, G , CURTI, C , CASIRAGHI, G , (2010) TARGETING ALPHA(V)BETA(3) INTEGRIN: DESIGN AND APPLICATIONS OF MONO- AND MULTIFUNCTIONAL RGD-BASED PEPTIDES AND SEMIPEPTIDES.CURRENT MEDICINAL CHEMISTRY. VOL. 17. ISSUE 13. P. 1255 -1299 109 49% 50
7 SHELDRAKE, HM , PATTERSON, LH , (2014) STRATEGIES TO INHIBIT TUMOR ASSOCIATED INTEGRIN RECEPTORS: RATIONALE FOR DUAL AND MULTI-ANTAGONISTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 15. P. 6301 -6315 80 57% 18
8 GAERTNER, FC , KESSLER, H , WESTER, HJ , SCHWAIGER, M , BEER, AJ , (2012) RADIOLABELLED RGD PEPTIDES FOR IMAGING AND THERAPY.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. VOL. 39. ISSUE . P. 126 -138 54 76% 78
9 HAUBNER, R , DECRISTOFORO, C , (2009) RADIOLABELLED RGD PEPTIDES AND PEPTIDOMIMETICS FOR TUMOUR TARGETING.FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 14. ISSUE . P. 872 -886 66 78% 45
10 ZHOU, Y , CHAKRABORTY, S , LIU, S , (2011) RADIOLABELED CYCLIC RGD PEPTIDES AS RADIOTRACERS FOR IMAGING TUMORS AND THROMBOSIS BY SPECT.THERANOSTICS. VOL. 1. ISSUE . P. 58 -82 107 43% 50

Classes with closest relation at Level 1


Rank Class id link
1 13046 PHAGE DISPLAY//IN VIVO PHAGE DISPLAY//NGR HTNF
2 36285 RECOMBINANT FIBRONECTIN FRAGMENT//CBD HEPII POLYPEPTIDE//ND2001
3 19200 LTBP//ALPHA V BETA 6//INTEGRIN ALPHA V BETA 6
4 2335 INTEGRIN//INTEGRIN ALPHA 6 BETA 4//VLA 1
5 15142 DISINTEGRIN//C TYPE LECTIN LIKE PROTEIN//ECHISTATIN
6 6389 KINDLIN//KINDLIN 2//TALIN
7 25796 ANOIKIS//MED ENGN AFEKA//BIOL CELLULAIRE EXPT
8 25952 CAM DR//CELL ADHESION MEDIATED DRUG RESISTANCE//RECEPTOR BIOL TUMOR METASTASIS
9 28898 RGD BINDING PROTEIN//SYNAPTEGRIN 1//BRAIN CAPILLARY DENSITY
10 2534 PEPTIDE RECEPTOR RADIONUCLIDE THERAPY//RADIOL CHEM//PRRT

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