Class information for:
Level 1: HEMOZOIN//BETA HEMATIN//4 AMINOQUINOLINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6333 1497 40.2 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
324 3       MALARIA//PLASMODIUM FALCIPARUM//MALARIA JOURNAL 38530
54 2             MALARIA//PLASMODIUM FALCIPARUM//MALARIA JOURNAL 29634
6333 1                   HEMOZOIN//BETA HEMATIN//4 AMINOQUINOLINE 1497

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HEMOZOIN authKW 863266 5% 52% 81
2 BETA HEMATIN authKW 744084 3% 79% 46
3 4 AMINOQUINOLINE authKW 549409 3% 57% 47
4 FERROQUINE authKW 337159 2% 72% 23
5 CHLOROQUINE authKW 294620 10% 10% 148
6 FERRIPROTOPORPHYRIN IX authKW 283181 1% 73% 19
7 HAEMOZOIN authKW 270312 2% 49% 27
8 BETA HAEMATIN authKW 237327 1% 73% 16
9 ANTIMALARIAL authKW 214075 7% 9% 112
10 AMODIAQUINE authKW 164476 3% 21% 38

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Parasitiology 9943 16% 0% 236
2 Chemistry, Medicinal 7147 21% 0% 312
3 Tropical Medicine 4709 9% 0% 128
4 Pharmacology & Pharmacy 1492 20% 0% 304
5 Biochemistry & Molecular Biology 1153 26% 0% 391
6 Chemistry, Organic 394 9% 0% 133
7 Microbiology 363 8% 0% 118
8 Chemistry, Inorganic & Nuclear 271 6% 0% 87
9 Biophysics 220 5% 0% 82
10 Public, Environmental & Occupational Health 170 6% 0% 86

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROGRAM TUMOR BIOL 107701 1% 41% 13
2 EUROPEAN CHEM POLYMERS MAT ECPM 62455 0% 44% 7
3 REGULAT DEV ERS CHIM 61188 0% 100% 3
4 SETOR QUIM ORGAN 61188 0% 100% 3
5 CSSON 50985 0% 50% 5
6 SOUTH AFRICAN MED COUNCIL DRUG DISCOVERY DE 46616 0% 57% 4
7 CNRS UMR 8576IFR 147 45890 0% 75% 3
8 IFR CNRS 63 45890 0% 75% 3
9 PRPID 45890 0% 75% 3
10 DDW DPU 40792 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 6888 3% 1% 44
2 ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY 5143 2% 1% 28
3 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 4982 3% 1% 48
4 INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE 4578 0% 4% 6
5 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 4503 5% 0% 73
6 JOURNAL OF MEDICINAL CHEMISTRY 3688 4% 0% 63
7 EXPERIMENTAL PARASITOLOGY 3650 2% 1% 30
8 BIOCHEMICAL PHARMACOLOGY 3386 4% 0% 56
9 BIOORGANIC & MEDICINAL CHEMISTRY 2976 3% 0% 44
10 PARASITOLOGY TODAY 2495 1% 1% 12

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HEMOZOIN 863266 5% 52% 81 Search HEMOZOIN Search HEMOZOIN
2 BETA HEMATIN 744084 3% 79% 46 Search BETA+HEMATIN Search BETA+HEMATIN
3 4 AMINOQUINOLINE 549409 3% 57% 47 Search 4+AMINOQUINOLINE Search 4+AMINOQUINOLINE
4 FERROQUINE 337159 2% 72% 23 Search FERROQUINE Search FERROQUINE
5 CHLOROQUINE 294620 10% 10% 148 Search CHLOROQUINE Search CHLOROQUINE
6 FERRIPROTOPORPHYRIN IX 283181 1% 73% 19 Search FERRIPROTOPORPHYRIN+IX Search FERRIPROTOPORPHYRIN+IX
7 HAEMOZOIN 270312 2% 49% 27 Search HAEMOZOIN Search HAEMOZOIN
8 BETA HAEMATIN 237327 1% 73% 16 Search BETA+HAEMATIN Search BETA+HAEMATIN
9 ANTIMALARIAL 214075 7% 9% 112 Search ANTIMALARIAL Search ANTIMALARIAL
10 AMODIAQUINE 164476 3% 21% 38 Search AMODIAQUINE Search AMODIAQUINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 ROEPE, PD , GORKA, AP , DE DIOS, A , (2013) QUINOLINE DRUG-HEME INTERACTIONS AND IMPLICATIONS FOR ANTIMALARIAL CYTOSTATIC VERSUS CYTOCIDAL ACTIVITIES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 13. P. 5231 -5246 115 72% 36
2 O'NEILL, PM , WARD, SA , BERRY, NG , JEYADEVAN, JP , BIAGINI, GA , ASADOLLALY, E , PARK, BK , BRAY, PG , (2006) A MEDICINAL CHEMISTRY PERSPECTIVE ON 4-AMINOQUINOLINE ANTIMALARIAL DRUGS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 6. ISSUE 5. P. 479-507 88 78% 48
3 EGAN, TJ , (2008) RECENT ADVANCES IN UNDERSTANDING THE MECHANISM OF HEMOZOIN (MALARIA PIGMENT) FORMATION.JOURNAL OF INORGANIC BIOCHEMISTRY. VOL. 102. ISSUE 5-6. P. 1288-1299 65 89% 78
4 FITCH, CD , (2004) FERRIPROTOPORPHYRIN IX, PHOSPHOLIPIDS, AND THE ANTIMALARIAL ACTIONS OF QUINOLINE DRUGS.LIFE SCIENCES. VOL. 74. ISSUE 16. P. 1957-1972 74 79% 121
5 BIOT, C , NAVARRO, M , CASTRO, W , (2012) BIOORGANOMETALLIC COMPOUNDS WITH ANTIMALARIAL TARGETS: INHIBITING HEMOZOIN FORMATION.ORGANOMETALLICS. VOL. 31. ISSUE 16. P. 5715 -5727 66 65% 51
6 TEIXEIRA, C , VALE, N , PEREZ, B , GOMES, A , GOMES, JRB , GOMES, P , (2014) "RECYCLING" CLASSICAL DRUGS FOR MALARIA.CHEMICAL REVIEWS. VOL. 114. ISSUE 22. P. 11164 -11220 117 36% 18
7 FOLEY, M , TILLEY, L , (1998) QUINOLINE ANTIMALARIALS: MECHANISMS OF ACTION AND RESISTANCE AND PROSPECTS FOR NEW AGENTS.PHARMACOLOGY & THERAPEUTICS. VOL. 79. ISSUE 1. P. 55 -87 126 42% 276
8 TEKWANI, BL , WALKER, LA , (2005) TARGETING THE HEMOZOIN SYNTHESIS PATHWAY FOR NEW ANTIMALARIAL DRUG DISCOVERY: TECHNOLOGIES FOR IN VITRO BETA-HEMATIN FORMATION ASSAY.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING. VOL. 8. ISSUE 1. P. 63-79 78 70% 43
9 KUMAR, S , GUHA, M , CHOUBEY, V , MAITY, P , BANDYOPADHYAY, U , (2007) ANTIMALARIAL DRUGS INHIBITING HEMOZOIN (BETA-HEMATIN) FORMATION: A MECHANISTIC UPDATE.LIFE SCIENCES. VOL. 80. ISSUE 9. P. 813-828 69 70% 63
10 EGAN, TJ , (2008) HAEMOZOIN FORMATION.MOLECULAR AND BIOCHEMICAL PARASITOLOGY. VOL. 157. ISSUE 2. P. 127-136 56 79% 82

Classes with closest relation at Level 1


Rank Class id link
1 27518 CHIMIOSENSIBIL PALUDISME//MULTIDENTATE AMINOTHIOLS//MEROZOITE RELEASE
2 196 PLASMODIUM FALCIPARUM//PFCRT//PFMDR1
3 13541 NEW PERMEABILITY PATHWAYS//CHOLINE ANALOGUES//PFHT
4 25058 DRUG METAB MOL TOXICOL S//KUVIN TROP DIS//P VINCKEI PETTERI
5 10701 PLASMEPSIN//CRUZIPAIN//FALCIPAIN
6 12529 APICOPLAST//MED MALARIA VENTURE//DIS DEV WORLD
7 37706 INDOLONE N OXIDES//2 2 PYRIDYLISATOGEN//ISATOGENS
8 9976 HYDROXYCHLOROQUINE//CHLOROQUINE//PLAQUENIL
9 757 ARTEMISININ//ARTEMISIA ANNUA//DIHYDROARTEMISININ
10 12814 ANTIMALARIAL PLANTS//ANTIPLASMODIAL ACTIVITY//PICRALIMA NITIDA

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