Class information for:
Level 1: SCLEROSTIN//SOST//LRP5

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9336 1165 46.5 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
27 3       DEVELOPMENTAL BIOLOGY//DEVELOPMENT//AGR2 109777
1425 2             WNT//BETA CATENIN//FRIZZLED 7942
9336 1                   SCLEROSTIN//SOST//LRP5 1165

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SCLEROSTIN authKW 3796702 20% 61% 238
2 SOST authKW 1174952 5% 73% 61
3 LRP5 authKW 562218 5% 39% 55
4 SCLEROSTEOSIS authKW 462320 2% 84% 21
5 SCLEROSTIN ANTIBODY authKW 455002 2% 69% 25
6 ROMOSOZUMAB authKW 233114 1% 68% 13
7 VAN BUCHEM DISEASE authKW 187201 1% 71% 10
8 BLOSOZUMAB authKW 186373 1% 89% 8
9 DKK1 authKW 176094 3% 20% 34
10 HIGH BONE MASS authKW 170346 1% 50% 13

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Endocrinology & Metabolism 11258 38% 0% 443
2 Cell Biology 1141 18% 0% 204
3 Cell & Tissue Engineering 625 2% 0% 26
4 Developmental Biology 372 4% 0% 46
5 Biochemistry & Molecular Biology 335 18% 0% 211
6 Rheumatology 212 3% 0% 32
7 Genetics & Heredity 153 6% 0% 72
8 Dentistry, Oral Surgery & Medicine 136 3% 0% 38
9 Medicine, Research & Experimental 121 5% 0% 58
10 Orthopedics 111 3% 0% 38

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENE FUNCT TARGET VALIDAT 81899 0% 63% 5
2 MUSCULOSKELETAL DIS AREA 73192 1% 31% 9
3 DIABET CLIN PEDIAT 2 52418 0% 100% 2
4 EXPT ORTHOPAED KEF 52418 0% 100% 2
5 FUJI MEM MED SCI 52418 0% 100% 2
6 CELL SIGNALING CARCINOGENESIS 50386 1% 19% 10
7 ENDOCRINOLMETAB BONE DIS UNIT 41930 0% 40% 4
8 METAB DISORDERS 39061 3% 5% 32
9 ABS BIOMED SCI 34944 0% 67% 2
10 ENDOCRINOL RETICEF 34944 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BONE AND MINERAL RESEARCH 52188 10% 2% 115
2 BONE 29831 7% 1% 87
3 CURRENT OSTEOPOROSIS REPORTS 5228 1% 3% 7
4 BONE RESEARCH 4228 0% 4% 4
5 CALCIFIED TISSUE INTERNATIONAL 3922 2% 1% 27
6 OSTEOPOROSIS INTERNATIONAL 3850 2% 1% 27
7 JOURNAL OF CELLULAR BIOCHEMISTRY 2265 2% 0% 28
8 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2178 4% 0% 45
9 REVIEWS IN ENDOCRINE & METABOLIC DISORDERS 1449 0% 1% 5
10 JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS 753 0% 1% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SCLEROSTIN 3796702 20% 61% 238 Search SCLEROSTIN Search SCLEROSTIN
2 SOST 1174952 5% 73% 61 Search SOST Search SOST
3 LRP5 562218 5% 39% 55 Search LRP5 Search LRP5
4 SCLEROSTEOSIS 462320 2% 84% 21 Search SCLEROSTEOSIS Search SCLEROSTEOSIS
5 SCLEROSTIN ANTIBODY 455002 2% 69% 25 Search SCLEROSTIN+ANTIBODY Search SCLEROSTIN+ANTIBODY
6 ROMOSOZUMAB 233114 1% 68% 13 Search ROMOSOZUMAB Search ROMOSOZUMAB
7 VAN BUCHEM DISEASE 187201 1% 71% 10 Search VAN+BUCHEM+DISEASE Search VAN+BUCHEM+DISEASE
8 BLOSOZUMAB 186373 1% 89% 8 Search BLOSOZUMAB Search BLOSOZUMAB
9 DKK1 176094 3% 20% 34 Search DKK1 Search DKK1
10 HIGH BONE MASS 170346 1% 50% 13 Search HIGH+BONE+MASS Search HIGH+BONE+MASS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BARON, R , KNEISSEL, M , (2013) WNT SIGNALING IN BONE HOMEOSTASIS AND DISEASE: FROM HUMAN MUTATIONS TO TREATMENTS.NATURE MEDICINE. VOL. 19. ISSUE 2. P. 179-192 119 54% 356
2 KE, HZ , RICHARDS, WG , LI, XD , OMINSKY, MS , (2012) SCLEROSTIN AND DICKKOPF-1 AS THERAPEUTIC TARGETS IN BONE DISEASES.ENDOCRINE REVIEWS. VOL. 33. ISSUE 5. P. 747 -783 106 50% 107
3 MONROE, DG , MCGEE-LAWRENCE, ME , OURSLER, MJ , WESTENDORF, JJ , (2012) UPDATE ON WNT SIGNALING IN BONE CELL BIOLOGY AND BONE DISEASE.GENE. VOL. 492. ISSUE 1. P. 1-18 107 40% 152
4 LERNER, UH , OHLSSON, C , (2015) THE WNT SYSTEM: BACKGROUND AND ITS ROLE IN BONE.JOURNAL OF INTERNAL MEDICINE. VOL. 277. ISSUE 6. P. 630 -649 75 66% 8
5 WEIVODA, MM , OURSLER, MJ , (2014) DEVELOPMENTS IN SCLEROSTIN BIOLOGY: REGULATION OF GENE EXPRESSION, MECHANISMS OF ACTION, AND PHYSIOLOGICAL FUNCTIONS.CURRENT OSTEOPOROSIS REPORTS. VOL. 12. ISSUE 1. P. 107 -114 60 91% 7
6 COSTA, AG , BILEZIKIAN, JP , LEWIECKI, EM , (2014) UPDATE ON ROMOSOZUMAB: A HUMANIZED MONOCLONAL ANTIBODY TO SCLEROSTIN.EXPERT OPINION ON BIOLOGICAL THERAPY. VOL. 14. ISSUE 5. P. 697 -707 55 93% 9
7 APPELMAN-DIJKSTRA, NM , PAPAPOULOS, SE , (2016) SCLEROSTIN INHIBITION IN THE MANAGEMENT OF OSTEOPOROSIS.CALCIFIED TISSUE INTERNATIONAL. VOL. 98. ISSUE 4. P. 370 -380 50 86% 3
8 ROSSINI, M , GATTI, D , ADAMI, S , (2013) INVOLVEMENT OF WNT/BETA-CATENIN SIGNALING IN THE TREATMENT OF OSTEOPOROSIS.CALCIFIED TISSUE INTERNATIONAL. VOL. 93. ISSUE 2. P. 121-132 62 70% 45
9 HONASOGE, M , RAO, AD , RAO, SD , (2014) SCLEROSTIN: RECENT ADVANCES AND CLINICAL IMPLICATIONS.CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY. VOL. 21. ISSUE 6. P. 437 -446 68 73% 5
10 WANG, YP , LI, YP , PAULSON, C , SHAO, JZ , ZHANG, XL , WU, MR , CHEN, W , (2014) WNT AND THE WNT SIGNALING PATHWAY IN BONE DEVELOPMENT AND DISEASE.FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 19. ISSUE . P. 379 -407 102 36% 46

Classes with closest relation at Level 1


Rank Class id link
1 11953 DKK 3//DICKKOPF 3//DKK3
2 7683 TERIPARATIDE//PARATHYROID HORMONE//PTH
3 2975 OSTEOCYTE//MECHANICAL LOADING//BONE FLUID FLOW
4 17458 MYELOMA BONE DISEASE//MULTIPLE MYELOMA//BONE DISEASE
5 8983 SOX9//CHONDROCYTE DIFFERENTIATION//IHH
6 3835 MOL STAT GENET//BONE MINERAL DENSITY//BMD
7 7164 RUNX2//CLEIDOCRANIAL DYSPLASIA//CBFA1
8 981 BETA CATENIN//AXIN//WNT
9 10505 OSTEOPETROSIS//CRANIOMETAPHYSEAL DYSPLASIA//CAMURATI ENGELMANN DISEASE
10 22292 PAOLO SOTGIU QUANTITAT EVOLUTIONARY PSYCHI//BARWON BIOMED//TPH 1

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