Class information for:
Level 2: ALPHA 1 ANTITRYPSIN DEFICIENCY//ALPHA 1 ANTITRYPSIN//ALPHA1 ANTITRYPSIN DEFICIENCY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1906 5908 35.8 66%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
1906 2             ALPHA 1 ANTITRYPSIN DEFICIENCY//ALPHA 1 ANTITRYPSIN//ALPHA1 ANTITRYPSIN DEFICIENCY 5908
1007 1                   ALPHA 1 ANTITRYPSIN DEFICIENCY//ALPHA 1 ANTITRYPSIN//ALPHA1 ANTITRYPSIN DEFICIENCY 2906
7218 1                   ELAFIN//SLPI//SECRETORY LEUKOCYTE PROTEASE INHIBITOR 1391
13510 1                   ELASTASE INHIBITOR//PROTEINASE K INHIBITOR//HUMAN LEUKOCYTE ELASTASE 832
23573 1                   CAP37//CATIONIC ANTIMICROBIAL PROTEIN//AZUROPHIL GRANULE 341
24005 1                   NEUTROPHIL ELASTASE INHIBITOR//SIVELESTAT//NEUTROPHIL ELASTASE 326
34382 1                   TETRANECTIN//COILED COIL DOMAIN CONTAINING 3 GENE//FAVINE GENE 112

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ALPHA 1 ANTITRYPSIN DEFICIENCY authKW 643467 3% 69% 181
2 ALPHA 1 ANTITRYPSIN authKW 596775 4% 45% 258
3 ALPHA1 ANTITRYPSIN DEFICIENCY authKW 379112 2% 69% 107
4 ALPHA1 ANTITRYPSIN authKW 331524 2% 45% 144
5 ELAFIN authKW 279493 1% 78% 69
6 SERPIN authKW 262884 4% 23% 220
7 SLPI authKW 225089 1% 68% 64
8 SECRETORY LEUKOCYTE PROTEASE INHIBITOR authKW 181891 1% 70% 50
9 NEUTROPHIL ELASTASE authKW 164826 2% 27% 118
10 ANTITRYPSIN authKW 123973 1% 67% 36

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Respiratory System 19667 15% 0% 910
2 Biochemistry & Molecular Biology 6079 29% 0% 1733
3 Medicine, Research & Experimental 1517 7% 0% 419
4 Critical Care Medicine 1406 3% 0% 198
5 Biophysics 1114 6% 0% 357
6 Chemistry, Medicinal 1073 5% 0% 280
7 Cell Biology 926 8% 0% 497
8 Medical Laboratory Technology 718 2% 0% 123
9 Pathology 671 4% 0% 219
10 Genetics & Heredity 581 6% 0% 329

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LUNG INVEST UNIT 38246 0% 37% 20
2 LUNG FUNCT SLEEP 31248 0% 55% 11
3 PROT STRAIN 25833 0% 100% 5
4 AD T PROJECT 23010 0% 64% 7
5 BIODEF MED 22452 0% 43% 10
6 CAMBRIDGE MED 22193 2% 5% 95
7 EVALUAT RISKS HUMAN REPROD 21526 0% 83% 5
8 BIOCHIM BIOL MOL HMNO 15500 0% 100% 3
9 DIAG INHERITED ANTITRYPSIN DEFICIENCY ALPHA1 15500 0% 100% 3
10 PEDIATUPMC NEWBORN MED PROGRAM 15500 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AMERICAN REVIEW OF RESPIRATORY DISEASE 23447 3% 3% 168
2 COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 11357 1% 6% 37
3 BIOLOGICAL CHEMISTRY HOPPE-SEYLER 11308 1% 4% 58
4 CLINICAL RESPIRATORY PHYSIOLOGY-BULLETIN EUROPEEN DE PHYSIOPATHOLOGIE RESPIRATOIRE 6343 0% 9% 14
5 HUMAN HEREDITY 5696 1% 2% 48
6 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 4471 1% 1% 67
7 EXPERIMENTAL LUNG RESEARCH 2940 1% 2% 32
8 EUROPEAN RESPIRATORY JOURNAL 2297 1% 1% 65
9 EUROPEAN JOURNAL OF RESPIRATORY DISEASES 2220 0% 2% 25
10 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 2063 0% 2% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ALPHA 1 ANTITRYPSIN DEFICIENCY 643467 3% 69% 181 Search ALPHA+1+ANTITRYPSIN+DEFICIENCY Search ALPHA+1+ANTITRYPSIN+DEFICIENCY
2 ALPHA 1 ANTITRYPSIN 596775 4% 45% 258 Search ALPHA+1+ANTITRYPSIN Search ALPHA+1+ANTITRYPSIN
3 ALPHA1 ANTITRYPSIN DEFICIENCY 379112 2% 69% 107 Search ALPHA1+ANTITRYPSIN+DEFICIENCY Search ALPHA1+ANTITRYPSIN+DEFICIENCY
4 ALPHA1 ANTITRYPSIN 331524 2% 45% 144 Search ALPHA1+ANTITRYPSIN Search ALPHA1+ANTITRYPSIN
5 ELAFIN 279493 1% 78% 69 Search ELAFIN Search ELAFIN
6 SERPIN 262884 4% 23% 220 Search SERPIN Search SERPIN
7 SLPI 225089 1% 68% 64 Search SLPI Search SLPI
8 SECRETORY LEUKOCYTE PROTEASE INHIBITOR 181891 1% 70% 50 Search SECRETORY+LEUKOCYTE+PROTEASE+INHIBITOR Search SECRETORY+LEUKOCYTE+PROTEASE+INHIBITOR
9 NEUTROPHIL ELASTASE 164826 2% 27% 118 Search NEUTROPHIL+ELASTASE Search NEUTROPHIL+ELASTASE
10 ANTITRYPSIN 123973 1% 67% 36 Search ANTITRYPSIN Search ANTITRYPSIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SANTANGELO, S , SCARLATA, S , POETA, ML , BIALAS, AJ , PAONE, G , INCALZI, RA , (2017) ALPHA-1 ANTITRYPSIN DEFICIENCY: CURRENT PERSPECTIVE FROM GENETICS TO DIAGNOSIS AND THERAPEUTIC APPROACHES.CURRENT MEDICINAL CHEMISTRY. VOL. 24. ISSUE 1. P. 65 -90 152 81% 0
2 STOLLER, JK , ABOUSSOUAN, LS , (2012) A REVIEW OF ALPHA(1)-ANTITRYPSIN DEFICIENCY.AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. VOL. 185. ISSUE 3. P. 246 -259 116 81% 83
3 HENAO, MP , CRAIG, TJ , (2016) RECENT ADVANCES IN UNDERSTANDING AND TREATING COPD RELATED TO (1)-ANTITRYPSIN DEFICIENCY.EXPERT REVIEW OF RESPIRATORY MEDICINE. VOL. 10. ISSUE 12. P. 1281 -1294 119 88% 0
4 GREENE, CM , MARCINIAK, SJ , TECKMAN, J , FERRAROTTI, I , BRANTLY, ML , LOMAS, DA , STOLLER, JK , MCELVANEY, NG , (2016) ALPHA 1-ANTITRYPSIN DEFICIENCY.NATURE REVIEWS DISEASE PRIMERS. VOL. 2. ISSUE . P. - 127 76% 0
5 GOOPTU, B , LOMAS, DA , (2009) CONFORMATIONAL PATHOLOGY OF THE SERPINS: THEMES, VARIATIONS, AND THERAPEUTIC STRATEGIES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 78. ISSUE . P. 147-176 111 78% 99
6 SALAHUDDIN, P , (2010) GENETIC VARIANTS OF ALPHA(1)-ANTITRYPSIN.CURRENT PROTEIN & PEPTIDE SCIENCE. VOL. 11. ISSUE 2. P. 101-117 119 85% 13
7 DICKENS, JA , LOMAS, DA , (2011) WHY HAS IT BEEN SO DIFFICULT TO PROVE THE EFFICACY OF ALPHA-1-ANTITRYPSIN REPLACEMENT THERAPY? INSIGHTS FROM THE STUDY OF DISEASE PATHOGENESIS.DRUG DESIGN DEVELOPMENT AND THERAPY. VOL. 5. ISSUE . P. 391 -405 104 92% 18
8 GOOPTU, B , DICKENS, JA , LOMAS, DA , (2014) THE MOLECULAR AND CELLULAR PATHOLOGY OF ALPHA(1)-ANTITRYPSIN DEFICIENCY.TRENDS IN MOLECULAR MEDICINE. VOL. 20. ISSUE 2. P. 116 -127 95 86% 17
9 EKEOWA, UI , GOOPTU, B , BELORGEY, D , HAGGLOF, P , KARLSSON-LI, S , MIRANDA, E , PEREZ, J , MACLEOD, I , KROGER, H , MARCINIAK, SJ , ET AL (2009) ALPHA(1)-ANTITRYPSIN DEFICIENCY, CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND THE SERPINOPATHIES.CLINICAL SCIENCE. VOL. 116. ISSUE 11-12. P. 837-850 122 78% 30
10 MOREAU, T , BARANGER, K , DADE, S , DALLET-CHOISY, S , GUYOTL, N , ZANI, ML , (2008) MULTIFACETED ROLES OF HUMAN ELAFIN AND SECRETORY LEUKOCYTE PROTEINASE INHIBITOR (SLPI), TWO SERINE PROTEASE INHIBITORS OF THE CHELONIANIN FAMILY.BIOCHIMIE. VOL. 90. ISSUE 2. P. 284 -295 103 82% 88

Classes with closest relation at Level 2


Rank Class id link
1 2693 ELASTIN//ELASTIN LIKE POLYPEPTIDE//TROPOELASTIN
2 3099 ALPHA 2 MACROGLOBULIN//LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN//LRP1
3 1549 CYCLOTIDES//BOWMAN BIRK INHIBITOR//TRYPSIN INHIBITOR
4 637 TISSUE FACTOR//THROMBOMODULIN//PROTEIN C
5 3090 HEREDITARY ANGIOEDEMA//C1 INHIBITOR//ANGIOEDEMA
6 2108 PULMONARY INTRAVASCULAR MACROPHAGES//ACUTE LUNG INJURY//CIRCULATORY SHOCK
7 206 CHRONIC OBSTRUCTIVE PULMONARY DISEASE//COPD//RESPIRATORY SYSTEM
8 3384 CIGARETTE SMOKE//ENVIRONMENTAL CIGARETTE SMOKE//LUNG TUMOR
9 2683 NEUTROPHIL EXTRACELLULAR TRAPS//SEVERE CONGENITAL NEUTROPENIA//NETOSIS
10 3694 GUANIDINOBENZOATASE//CELL SURFACE PROTEASE//MURINE MODELS OF SLE

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