Class information for:
Level 2: BLOOD BRAIN BARRIER//CEREBROLYSIN//TYR MIF 1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2409 4189 41.9 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
258 3       STROKE//INTRACEREBRAL HEMORRHAGE//CEREBRAL ISCHEMIA 44849
2409 2             BLOOD BRAIN BARRIER//CEREBROLYSIN//TYR MIF 1 4189
4989 1                   BLOOD BRAIN BARRIER//BBB//TIGHT JUNCTION 1691
12145 1                   RMP 7//INTRACAROTID CHEMOTHERAPY//BLOOD TUMOR BARRIER 928
17033 1                   TYR MIF 1//MIF 1//BLOOD BRAIN BARRIER GRP 621
25962 1                   CEREBROLYSIN//CEREBROLYSIN R//QEEG SLOWING 267
27352 1                   SURG SCI ANESTHESIOL INTENS CARE MED//H 290 51//SURG SCI ANAESTHESIOL INTENS CARE MED 231
27403 1                   EVANS BLUE//1 DEOXY 1 NITRO D MANNITOL//ADENYLATE CYSLASE 230
27774 1                   VASOGENIC BRAIN EDEMA//IMMUNOGLOBULIN G UPTAKE//NECROTIC NEURONS 221

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 BLOOD BRAIN BARRIER authKW 974798 25% 13% 1038
2 CEREBROLYSIN authKW 627368 3% 79% 109
3 TYR MIF 1 authKW 207283 1% 89% 32
4 SURG SCI ANESTHESIOL INTENS CARE MED address 184592 1% 67% 38
5 BLOOD BRAIN BARRIER GRP address 123693 1% 41% 41
6 BBB address 113432 1% 65% 24
7 MIF 1 authKW 109609 0% 79% 19
8 TIGHT JUNCTION authKW 88797 5% 6% 191
9 H 290 51 authKW 87450 0% 100% 12
10 RMP 7 authKW 71742 0% 62% 16

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Neurosciences 17089 38% 0% 1586
2 Clinical Neurology 7424 19% 0% 811
3 Pharmacology & Pharmacy 3206 18% 0% 761
4 Pathology 1353 6% 0% 240
5 Endocrinology & Metabolism 659 6% 0% 254
6 Oncology 517 8% 0% 330
7 Physiology 489 5% 0% 198
8 Cell Biology 456 7% 0% 310
9 Peripheral Vascular Diseases 328 3% 0% 141
10 Biochemistry & Molecular Biology 262 11% 0% 477

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SURG SCI ANESTHESIOL INTENS CARE MED 184592 1% 67% 38
2 BLOOD BRAIN BARRIER GRP 123693 1% 41% 41
3 BBB 113432 1% 65% 24
4 SURG SCI ANAESTHESIOL INTENS CARE MED 52878 0% 48% 15
5 PHARMACEUT CARE HLTH SCI 36999 1% 20% 26
6 IECNSIR 36438 0% 100% 5
7 PHYSIOPATHOL BARRIERE HEMATO ENCEPHAL 32791 0% 75% 6
8 LBHE 30393 0% 38% 11
9 BLOOD BRAIN BARRIER 28678 0% 25% 16
10 CEREBROVASC 26788 2% 6% 63

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF NEURO-ONCOLOGY 15320 3% 2% 107
2 ACTA NEUROPATHOLOGICA 10458 2% 2% 92
3 JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 9982 2% 2% 86
4 JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT 7169 1% 4% 28
5 BRAIN RESEARCH 4952 4% 0% 184
6 PEPTIDES 4940 2% 1% 78
7 PAROI ARTERIELLE-ARTERIAL WALL 4663 0% 13% 5
8 JOURNAL OF NEUROCHEMISTRY 3622 2% 1% 104
9 ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA 3094 1% 1% 30
10 CANCER DRUG DELIVERY 3065 0% 6% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 BLOOD BRAIN BARRIER 974798 25% 13% 1038 Search BLOOD+BRAIN+BARRIER Search BLOOD+BRAIN+BARRIER
2 CEREBROLYSIN 627368 3% 79% 109 Search CEREBROLYSIN Search CEREBROLYSIN
3 TYR MIF 1 207283 1% 89% 32 Search TYR+MIF+1 Search TYR+MIF+1
4 MIF 1 109609 0% 79% 19 Search MIF+1 Search MIF+1
5 TIGHT JUNCTION 88797 5% 6% 191 Search TIGHT+JUNCTION Search TIGHT+JUNCTION
6 H 290 51 87450 0% 100% 12 Search H+290+51 Search H+290+51
7 RMP 7 71742 0% 62% 16 Search RMP+7 Search RMP+7
8 TRANSENDOTHELIAL ELECTRICAL RESISTANCE 69135 1% 43% 22 Search TRANSENDOTHELIAL+ELECTRICAL+RESISTANCE Search TRANSENDOTHELIAL+ELECTRICAL+RESISTANCE
9 BLOOD TUMOR BARRIER 66949 1% 37% 25 Search BLOOD+TUMOR+BARRIER Search BLOOD+TUMOR+BARRIER
10 CEREBRAL ENDOTHELIAL CELLS 62150 1% 37% 23 Search CEREBRAL+ENDOTHELIAL+CELLS Search CEREBRAL+ENDOTHELIAL+CELLS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DELI, MA , ABRAHAM, CS , KATAOKA, Y , NIWA, M , (2005) PERMEABILITY STUDIES ON IN VITRO BLOOD-BRAIN BARRIER MODELS: PHYSIOLOGY, PATHOLOGY, AND PHARMACOLOGY.CELLULAR AND MOLECULAR NEUROBIOLOGY. VOL. 25. ISSUE 1. P. 59-127 126 68% 283
2 HELMS, HC , ABBOTT, NJ , BUREK, M , CECCHELLI, R , COURAUD, PO , DELI, MA , FORSTER, C , GALLA, HJ , ROMERO, IA , SHUSTA, EV , ET AL (2016) IN VITRO MODELS OF THE BLOOD-BRAIN BARRIER: AN OVERVIEW OF COMMONLY USED BRAIN ENDOTHELIAL CELL CULTURE MODELS AND GUIDELINES FOR THEIR USE.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. VOL. 36. ISSUE 5. P. 862 -890 130 49% 6
3 WOLFF, A , ANTFOLK, M , BRODIN, B , TENJE, M , (2015) IN VITRO BLOOD-BRAIN BARRIER MODELS-AN OVERVIEW OF ESTABLISHED MODELS AND NEW MICROFLUIDIC APPROACHES.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 104. ISSUE 9. P. 2727 -2746 94 81% 9
4 BICKER, J , ALVES, G , FORTUNA, A , FALCAO, A , (2014) BLOOD-BRAIN BARRIER MODELS AND THEIR RELEVANCE FOR A SUCCESSFUL DEVELOPMENT OF CNS DRUG DELIVERY SYSTEMS: A REVIEW.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. VOL. 87. ISSUE 3. P. 409 -432 111 47% 36
5 WILHELM, I , KRIZBAI, IA , (2014) IN VITRO MODELS OF THE BLOOD-BRAIN BARRIER FOR THE STUDY OF DRUG DELIVERY TO THE BRAIN.MOLECULAR PHARMACEUTICS. VOL. 11. ISSUE 7. P. 1949 -1963 79 68% 21
6 WATSON, PMD , PATERSON, JC , THOM, G , GINMAN, U , LUNDQUIST, S , WEBSTER, CI , (2013) MODELLING THE ENDOTHELIAL BLOOD-CNS BARRIERS: A METHOD FOR THE PRODUCTION OF ROBUST IN VITRO MODELS OF THE RAT BLOOD-BRAIN BARRIER AND BLOOD-SPINAL CORD BARRIER.BMC NEUROSCIENCE. VOL. 14. ISSUE . P. - 70 81% 22
7 HE, YR , YAO, Y , TSIRKA, SE , CAO, Y , (2014) CELL-CULTURE MODELS OF THE BLOOD-BRAIN BARRIER.STROKE. VOL. 45. ISSUE 8. P. 2514 -2526 103 53% 13
8 APARICIO-BLANCO, J , MARTIN-SABROSO, C , TORRES-SUAREZ, AI , (2016) IN VITRO SCREENING OF NANOMEDICINES THROUGH THE BLOOD BRAIN BARRIER: A CRITICAL REVIEW.BIOMATERIALS. VOL. 103. ISSUE . P. 229 -255 134 39% 1
9 PAN, W , KASTIN, AJ , (2007) FROM MIF-1 TO ENDOMORPHIN: THE TYR-MIF-1 FAMILY OF PEPTIDES.PEPTIDES. VOL. 28. ISSUE 12. P. 2411 -2434 120 50% 25
10 CARDOSO, FL , BRITES, D , BRITO, MA , (2010) LOOKING AT THE BLOOD-BRAIN BARRIER: MOLECULAR ANATOMY AND POSSIBLE INVESTIGATION APPROACHES.BRAIN RESEARCH REVIEWS. VOL. 64. ISSUE 2. P. 328-363 113 34% 148

Classes with closest relation at Level 2


Rank Class id link
1 3470 CONVECTION ENHANCED DELIVERY//POLYANHYDRIDE//POLYESTER ANHYDRIDE
2 2123 GLYCOCALYX//MICROVASCULAR RESEARCH//ENDOTHELIAL GLYCOCALYX
3 1574 TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN
4 2177 NORMAL PRESSURE HYDROCEPHALUS//HYDROCEPHALUS//IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS
5 359 CEREBRAL ISCHEMIA//SPREADING DEPRESSION//JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
6 747 P GLYCOPROTEIN//MULTIDRUG RESISTANCE//MDR1
7 1155 PEPT1//ORGANIC CATION TRANSPORTER//OATP1B1
8 1979 BRAIN METASTASES//BRAIN METASTASIS//WHOLE BRAIN RADIOTHERAPY
9 2464 STREPTOZOTOCIN//KANGEN KARYU//HYPERCYTOLIPIDEMIA
10 3104 THYROTROPIN RELEASING HORMONE//TRH//TRH RECEPTOR

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