Class information for:
Level 2: NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2994 2568 54.8 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
468 3       GLUCOSINOLATES//BILIRUBIN//HEME OXYGENASE 24157
2994 2             NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT 2568
1613 1                   NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT 2568

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NRF2 authKW 4194202 35% 39% 905
2 KEAP1 authKW 1902268 8% 73% 218
3 ANTIOXIDANT RESPONSE ELEMENT authKW 651525 4% 52% 106
4 NF E2 RELATED FACTOR 2 authKW 239636 2% 40% 50
5 ARE authKW 202385 2% 35% 49
6 KELCH LIKE ECH ASSOCIATED PROTEIN 1 KEAP1 authKW 198142 1% 83% 20
7 NUCLEAR FACTOR ERYTHROID 2 RELATED FACTOR 2 authKW 170018 2% 28% 52
8 ENVIRONM PONSE PROJECT address 159235 1% 56% 24
9 ANTIOXIDANT RESPONSIVE ELEMENT authKW 157211 1% 58% 23
10 SULFORAPHANE authKW 113564 3% 12% 81

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 6022 41% 0% 1065
2 Cell Biology 2417 17% 0% 442
3 Toxicology 1752 8% 0% 218
4 Endocrinology & Metabolism 1660 11% 0% 279
5 Oncology 859 11% 0% 293
6 Pharmacology & Pharmacy 638 12% 0% 299
7 Chemistry, Medicinal 424 5% 0% 117
8 Biophysics 307 5% 0% 130
9 Medicine, Research & Experimental 179 4% 0% 111
10 Integrative & Complementary Medicine 144 1% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ENVIRONM PONSE PROJECT 159235 1% 56% 24
2 JACQUI WOOD CANC 96794 1% 31% 26
3 RADIOISOTOPE SCI 92227 1% 52% 15
4 BIOSCI DRUG DISCOVERY 71333 0% 100% 6
5 TSUKUBA ADV ALLIANCE 69483 3% 7% 82
6 ST S PONSE SCI 68571 1% 38% 15
7 ERNEST MARIO PHARM 57411 3% 6% 75
8 JIANG SU DRUG DESIGN OPTIMIZAT 54030 0% 45% 10
9 CHEM SAFETY SCI 51421 1% 29% 15
10 JST ERATO ENVIRONM PONSE PROJECT 50718 0% 53% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FREE RADICAL BIOLOGY AND MEDICINE 35783 6% 2% 161
2 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 20446 2% 3% 54
3 ANTIOXIDANTS & REDOX SIGNALING 12023 2% 2% 56
4 REDOX BIOLOGY 11021 1% 4% 21
5 TOXICOLOGY AND APPLIED PHARMACOLOGY 3068 2% 1% 51
6 GENES TO CELLS 2210 1% 1% 19
7 MOLECULAR AND CELLULAR BIOLOGY 1584 2% 0% 56
8 TOXICOLOGICAL SCIENCES 1362 1% 0% 24
9 JOURNAL OF BIOLOGICAL CHEMISTRY 1271 5% 0% 137
10 MOLECULAR NUTRITION & FOOD RESEARCH 1176 1% 1% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NRF2 4194202 35% 39% 905 Search NRF2 Search NRF2
2 KEAP1 1902268 8% 73% 218 Search KEAP1 Search KEAP1
3 ANTIOXIDANT RESPONSE ELEMENT 651525 4% 52% 106 Search ANTIOXIDANT+RESPONSE+ELEMENT Search ANTIOXIDANT+RESPONSE+ELEMENT
4 NF E2 RELATED FACTOR 2 239636 2% 40% 50 Search NF+E2+RELATED+FACTOR+2 Search NF+E2+RELATED+FACTOR+2
5 ARE 202385 2% 35% 49 Search ARE Search ARE
6 KELCH LIKE ECH ASSOCIATED PROTEIN 1 KEAP1 198142 1% 83% 20 Search KELCH+LIKE+ECH+ASSOCIATED+PROTEIN+1+KEAP1 Search KELCH+LIKE+ECH+ASSOCIATED+PROTEIN+1+KEAP1
7 NUCLEAR FACTOR ERYTHROID 2 RELATED FACTOR 2 170018 2% 28% 52 Search NUCLEAR+FACTOR+ERYTHROID+2+RELATED+FACTOR+2 Search NUCLEAR+FACTOR+ERYTHROID+2+RELATED+FACTOR+2
8 ANTIOXIDANT RESPONSIVE ELEMENT 157211 1% 58% 23 Search ANTIOXIDANT+RESPONSIVE+ELEMENT Search ANTIOXIDANT+RESPONSIVE+ELEMENT
9 SULFORAPHANE 113564 3% 12% 81 Search SULFORAPHANE Search SULFORAPHANE
10 NFE2L2 107356 1% 53% 17 Search NFE2L2 Search NFE2L2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SYKIOTIS, GP , BOHMANN, D , (2010) STRESS-ACTIVATED CAP'N'COLLAR TRANSCRIPTION FACTORS IN AGING AND HUMAN DISEASE.SCIENCE SIGNALING. VOL. 3. ISSUE 112. P. - 209 69% 204
2 HAYES, JD , DINKOVA-KOSTOVA, AT , (2014) THE NRF2 REGULATORY NETWORK PROVIDES AN INTERFACE BETWEEN REDOX AND INTERMEDIARY METABOLISM.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 39. ISSUE 4. P. 199-218 118 69% 190
3 KUMAR, H , KIM, IS , MORE, SV , KIM, BW , CHOI, DK , (2014) NATURAL PRODUCT-DERIVED PHARMACOLOGICAL MODULATORS OF NRF2/ARE PATHWAY FOR CHRONIC DISEASES.NATURAL PRODUCT REPORTS. VOL. 31. ISSUE 1. P. 109 -139 236 55% 42
4 TEBAY, LE , ROBERTSON, H , DURANT, ST , VITALE, SR , PENNING, TM , DINKOVA-KOSTOVA, AT , HAYES, JD , (2015) MECHANISMS OF ACTIVATION OF THE TRANSCRIPTION FACTOR NRF2 BY REDOX STRESSORS, NUTRIENT CUES, AND ENERGY STATUS AND THE PATHWAYS THROUGH WHICH IT ATTENUATES DEGENERATIVE DISEASE.FREE RADICAL BIOLOGY AND MEDICINE. VOL. 88. ISSUE . P. 108 -146 224 48% 33
5 MA, Q , (2013) ROLE OF NRF2 IN OXIDATIVE STRESS AND TOXICITY.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013. VOL. 53. ISSUE . P. 401-+ 116 62% 331
6 LU, MC , JI, JA , JIANG, ZY , YOU, QD , (2016) THE KEAP1-NRF2-ARE PATHWAY AS A POTENTIAL PREVENTIVE AND THERAPEUTIC TARGET: AN UPDATE.MEDICINAL RESEARCH REVIEWS. VOL. 36. ISSUE 5. P. 924 -963 146 76% 6
7 GEISMANN, C , ARLT, A , SEBENS, S , SCHAFER, H , (2014) CYTOPROTECTION "GONE ASTRAY": NRF2 AND ITS ROLE IN CANCER.ONCOTARGETS AND THERAPY. VOL. 7. ISSUE . P. 1497 -1518 184 68% 30
8 BAIRD, L , DINKOVA-KOSTOVA, AT , (2011) THE CYTOPROTECTIVE ROLE OF THE KEAP1-NRF2 PATHWAY.ARCHIVES OF TOXICOLOGY. VOL. 85. ISSUE 4. P. 241 -272 176 52% 266
9 HE, XQ , MA, Q , (2012) MOLECULAR BASIS OF ELECTROPHILIC AND OXIDATIVE DEFENSE: PROMISES AND PERILS OF NRF2.PHARMACOLOGICAL REVIEWS. VOL. 64. ISSUE 4. P. 1055 -1081 164 73% 75
10 MAGESH, S , CHEN, Y , HU, LQ , (2012) SMALL MOLECULE MODULATORS OF KEAP1-NRF2-ARE PATHWAY AS POTENTIAL PREVENTIVE AND THERAPEUTIC AGENTS.MEDICINAL RESEARCH REVIEWS. VOL. 32. ISSUE 4. P. 687 -726 153 60% 143

Classes with closest relation at Level 2


Rank Class id link
1 2122 GLUCOSINOLATES//SULFORAPHANE//ISOTHIOCYANATES
2 1296 HEME OXYGENASE//PORPHYRIA//HEME OXYGENASE 1
3 870 PEROXIREDOXIN//THIOREDOXIN//GLUTATHIONE
4 3959 HORMESIS//U SHAPED//J SHAPED
5 1924 URSOLIC ACID//BETULINIC ACID//OLEANOLIC ACID
6 2037 BAICALIN//BAICALEIN//QUERCETIN
7 3196 MNSOD//MANGANESE SUPEROXIDE DISMUTASE//SOD2
8 1741 GSTM1//GSTT1//GLUTATHIONE S TRANSFERASE
9 3893 PRL 3//ATF3//ATF5
10 1329 CURCUMIN//ZINGIBERACEAE//DIARYLHEPTANOID

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