Class information for:
Level 2: 6 MERCAPTOPURINE//THIOPURINE METHYLTRANSFERASE//AZATHIOPRINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3271 1920 35.0 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
380 3       CROHNS DISEASE//ULCERATIVE COLITIS//INFLAMMATORY BOWEL DISEASE 31889
3271 2             6 MERCAPTOPURINE//THIOPURINE METHYLTRANSFERASE//AZATHIOPRINE 1920
3737 1                   6 MERCAPTOPURINE//THIOPURINE METHYLTRANSFERASE//AZATHIOPRINE 1920

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 6 MERCAPTOPURINE authKW 2475801 15% 55% 284
2 THIOPURINE METHYLTRANSFERASE authKW 2305683 8% 92% 157
3 AZATHIOPRINE authKW 2168305 23% 31% 434
4 THIOPURINE S METHYLTRANSFERASE authKW 1369639 5% 90% 96
5 THIOPURINES authKW 1201618 7% 55% 138
6 TPMT authKW 1106533 4% 84% 83
7 MERCAPTOPURINE authKW 686912 4% 60% 72
8 6 THIOGUANINE NUCLEOTIDES authKW 685139 2% 96% 45
9 6 THIOGUANINE authKW 566055 4% 47% 75
10 THIOGUANINE NUCLEOTIDES authKW 287031 1% 95% 19

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Gastroenterology & Hepatology 11488 24% 0% 456
2 Pharmacology & Pharmacy 5194 32% 0% 605
3 Medical Laboratory Technology 1808 5% 0% 102
4 Oncology 719 12% 0% 229
5 Hematology 646 6% 0% 122
6 Pediatrics 372 6% 0% 111
7 Toxicology 247 4% 0% 80
8 Medicine, General & Internal 208 7% 0% 125
9 Dermatology 199 3% 0% 57
10 Chemistry, Analytical 180 6% 0% 109

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNIDAD TOXICOL MOL HEPAT 122319 1% 77% 10
2 PURINE 104582 1% 26% 25
3 PEDIAT ONCOL SE NETHERLANDS 63608 0% 100% 4
4 GASTROENTEROL GERIATR INTERNAL INTENS CARE 35778 0% 75% 3
5 HAEMATOL ONCOL OUTPATIENT 35778 0% 75% 3
6 INFLAMMATORY BOWEL DIS MED GASTROENT 31804 0% 100% 2
7 INFLAMMATORY DIS BIOL THER EUT PROGRAM 31804 0% 100% 2
8 PHARMACOTHER IE 31804 0% 100% 2
9 SECT CLIN HAEMATOL ONCOL 31804 0% 100% 2
10 SECT MED PHARMACOL 26497 0% 33% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THERAPEUTIC DRUG MONITORING 12342 3% 1% 54
2 ALIMENTARY PHARMACOLOGY & THERAPEUTICS 11371 4% 1% 68
3 JOURNAL OF CROHNS & COLITIS 9851 1% 2% 25
4 PHARMACOGENETICS 8102 1% 2% 22
5 FALK SYMPOSIUM 7697 2% 1% 37
6 PHARMACOGENOMICS 5569 1% 1% 25
7 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 3232 2% 1% 41
8 INFLAMMATORY BOWEL DISEASES 2930 1% 2% 11
9 CLINICAL PHARMACOLOGY & THERAPEUTICS 2920 2% 1% 33
10 PHARMACOGENETICS AND GENOMICS 2723 1% 1% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 6 MERCAPTOPURINE 2475801 15% 55% 284 Search 6+MERCAPTOPURINE Search 6+MERCAPTOPURINE
2 THIOPURINE METHYLTRANSFERASE 2305683 8% 92% 157 Search THIOPURINE+METHYLTRANSFERASE Search THIOPURINE+METHYLTRANSFERASE
3 AZATHIOPRINE 2168305 23% 31% 434 Search AZATHIOPRINE Search AZATHIOPRINE
4 THIOPURINE S METHYLTRANSFERASE 1369639 5% 90% 96 Search THIOPURINE+S+METHYLTRANSFERASE Search THIOPURINE+S+METHYLTRANSFERASE
5 THIOPURINES 1201618 7% 55% 138 Search THIOPURINES Search THIOPURINES
6 TPMT 1106533 4% 84% 83 Search TPMT Search TPMT
7 MERCAPTOPURINE 686912 4% 60% 72 Search MERCAPTOPURINE Search MERCAPTOPURINE
8 6 THIOGUANINE NUCLEOTIDES 685139 2% 96% 45 Search 6+THIOGUANINE+NUCLEOTIDES Search 6+THIOGUANINE+NUCLEOTIDES
9 6 THIOGUANINE 566055 4% 47% 75 Search 6+THIOGUANINE Search 6+THIOGUANINE
10 THIOGUANINE NUCLEOTIDES 287031 1% 95% 19 Search THIOGUANINE+NUCLEOTIDES Search THIOGUANINE+NUCLEOTIDES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MOON, W , LOFTUS, EV , (2016) REVIEW ARTICLE: RECENT ADVANCES IN PHARMACOGENETICS AND PHARMACOKINETICS FOR SAFE AND EFFECTIVE THIOPURINE THERAPY ININFLAMMATORY BOWEL DISEASE.ALIMENTARY PHARMACOLOGY & THERAPEUTICS. VOL. 43. ISSUE 8. P. 863 -883 170 87% 3
2 CHOUCHANA, L , NARJOZ, C , BEAUNE, P , LORIOT, MA , ROBLIN, X , (2012) REVIEW ARTICLE: THE BENEFITS OF PHARMACOGENETICS FOR IMPROVING THIOPURINE THERAPY IN INFLAMMATORY BOWEL DISEASE.ALIMENTARY PHARMACOLOGY & THERAPEUTICS. VOL. 35. ISSUE 1. P. 15 -36 175 85% 65
3 CABALEIRO, T , ROMAN, M , GISBERT, JP , ABAD-SANTOS, F , (2012) UTILITY OF ASSESSING THIOPURINE S-METHYLTRANSFERASE POLYMORPHISMS BEFORE AZATHIOPRINE THERAPY.CURRENT DRUG METABOLISM. VOL. 13. ISSUE 9. P. 1277 -1293 198 93% 3
4 VAN ASSELDONK, DP , DE BOER, NKH , PETERS, GJ , VELDKAMP, AI , MULDER, CJ , VAN BODEGRAVEN, AA , (2009) ON THERAPEUTIC DRUG MONITORING OF THIOPURINES IN INFLAMMATORY BOWEL DISEASE; PHARMACOLOGY, PHARMACOGENOMICS, DRUG INTOLERANCE AND CLINICAL RELEVANCE.CURRENT DRUG METABOLISM. VOL. 10. ISSUE 9. P. 981-997 163 88% 6
5 BLAKER, PA , ARENAS-HERNANDEZ, M , MARINAKI, AM , SANDERSON, JD , (2012) THE PHARMACOGENETIC BASIS OF INDIVIDUAL VARIATION IN THIOPURINE METABOLISM.PERSONALIZED MEDICINE. VOL. 9. ISSUE 7. P. 707 -725 137 88% 3
6 GISBERT, JP , GOMOLLON, F , (2008) THIOPURINE-INDUCED MYELOTOXICITY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A REVIEW.AMERICAN JOURNAL OF GASTROENTEROLOGY. VOL. 103. ISSUE 7. P. 1783 -1800 113 91% 80
7 LENNARD, L , (2014) IMPLEMENTATION OF TPMT TESTING.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 77. ISSUE 4. P. 704 -714 88 95% 15
8 TEML, A , SCHAEFFELER, E , HERRLINGER, KR , KLOTZ, U , SCHWAB, M , (2007) THIOPURINE TREATMENT IN INFLAMMATORY BOWEL DISEASE - CLINICAL PHARMACOLOGY AND IMPLICATION OF PHARMACOGENETICALLY GUIDED DOSING.CLINICAL PHARMACOKINETICS. VOL. 46. ISSUE 3. P. 187-208 133 73% 71
9 AL HADITHY, AFY , DE BOER, NKH , DERIJKS, LJJ , ESCHER, JC , MULDER, CJJ , BROUWERS, JRBJ , (2005) THIOPURINES IN INFLAMMATORY BOWEL DISEASE: PHARMACOGENETICS, THERAPEUTIC DRUG MONITORING AND CLINICAL RECOMMENDATIONS.DIGESTIVE AND LIVER DISEASE. VOL. 37. ISSUE 4. P. 282 -297 129 83% 56
10 SAHASRANAMAN, S , HOWARD, D , ROY, S , (2008) CLINICAL PHARMACOLOGY AND PHARMACOGENETICS OF THIOPURINES.EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 64. ISSUE 8. P. 753 -767 100 80% 144

Classes with closest relation at Level 2


Rank Class id link
1 52 CROHNS DISEASE//ULCERATIVE COLITIS//INFLAMMATORY BOWEL DISEASE
2 1684 METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER
3 3764 ETHYLENETHIOUREA//IODINE AZIDE REACTION//MANCOZEB
4 2679 PREGNANCY//MOTHERS RHEUMAT DIS//PREGNANCY RHEUMAT DIS
5 1807 PRIMARY BILIARY CIRRHOSIS//AUTOIMMUNE HEPATITIS//PRIMARY SCLEROSING CHOLANGITIS
6 3449 INFLIXIMAB//ETANERCEPT//ADALIMUMAB
7 1039 GENETIC TESTING//BIOBANK//JOURNAL OF GENETIC COUNSELING
8 2798 LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE
9 1176 THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL
10 2934 PYODERMA GANGRENOSUM//SWEETS SYNDROME//RELAPSING POLYCHONDRITIS

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