Class information for:
Level 2: PEDF//PIGMENT EPITHELIUM DERIVED FACTOR//PIGMENT EPITHELIUM DERIVED FACTOR PEDF

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4018 672 43.1 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
518 3       ANGIOGENESIS//RETINOPATHY OF PREMATURITY//ENDOSTATIN 20826
4018 2             PEDF//PIGMENT EPITHELIUM DERIVED FACTOR//PIGMENT EPITHELIUM DERIVED FACTOR PEDF 672
16123 1                   PEDF//PIGMENT EPITHELIUM DERIVED FACTOR//PIGMENT EPITHELIUM DERIVED FACTOR PEDF 672

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PEDF authKW 5072317 23% 72% 156
2 PIGMENT EPITHELIUM DERIVED FACTOR authKW 4447563 21% 69% 142
3 PIGMENT EPITHELIUM DERIVED FACTOR PEDF authKW 828846 3% 79% 23
4 SECT PROT STRUCT FUNCT address 451703 2% 76% 13
5 PATHOPHYSIOL THER EUT DIABET VASC COMPLIC address 361778 6% 20% 39
6 IL MORPHOL address 202402 1% 64% 7
7 PEDF R authKW 181753 1% 100% 4
8 EPC 1 authKW 145401 1% 80% 4
9 RADIOISOTOPE BASIC CLIN MED address 144868 2% 25% 13
10 FUNCT MOL MARINE MICROORGANISMS address 141981 1% 31% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Ophthalmology 2407 17% 0% 111
2 Medicine, Research & Experimental 579 12% 0% 80
3 Endocrinology & Metabolism 381 10% 0% 69
4 Biochemistry & Molecular Biology 338 22% 0% 149
5 Cell Biology 295 13% 0% 84
6 Oncology 178 10% 0% 70
7 Neurosciences 51 8% 0% 52
8 Pharmacology & Pharmacy 50 8% 0% 52
9 Pathology 43 3% 0% 20
10 Biotechnology & Applied Microbiology 43 5% 0% 33

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SECT PROT STRUCT FUNCT 451703 2% 76% 13
2 PATHOPHYSIOL THER EUT DIABET VASC COMPLIC 361778 6% 20% 39
3 IL MORPHOL 202402 1% 64% 7
4 RADIOISOTOPE BASIC CLIN MED 144868 2% 25% 13
5 FUNCT MOL MARINE MICROORGANISMS 141981 1% 31% 10
6 RETINAL CELL MOL BIOL 127596 3% 13% 21
7 CHINA TROP DIS CONTROL 116311 1% 32% 8
8 KALASALINGAM EDUC 102228 1% 38% 6
9 IVF INFERTIL UNIT OBSTET GYNECOL 90876 0% 100% 2
10 NEUROTROPH TORS SECT 81133 1% 36% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CURRENT MOLECULAR MEDICINE 3188 1% 1% 9
2 MOLECULAR VISION 2316 2% 0% 13
3 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 1554 4% 0% 26
4 EXPERIMENTAL EYE RESEARCH 1540 2% 0% 15
5 MICROVASCULAR RESEARCH 1374 1% 0% 9
6 NATO ADVANCED SCIENCE INSTITUTES SERIES, SERIES A, LIFE SCIENCES 1133 0% 1% 3
7 JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY 941 1% 0% 6
8 TRENDS IN MOLECULAR MEDICINE 584 1% 0% 4
9 INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 508 1% 0% 4
10 JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 438 1% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PEDF 5072317 23% 72% 156 Search PEDF Search PEDF
2 PIGMENT EPITHELIUM DERIVED FACTOR 4447563 21% 69% 142 Search PIGMENT+EPITHELIUM+DERIVED+FACTOR Search PIGMENT+EPITHELIUM+DERIVED+FACTOR
3 PIGMENT EPITHELIUM DERIVED FACTOR PEDF 828846 3% 79% 23 Search PIGMENT+EPITHELIUM+DERIVED+FACTOR+PEDF Search PIGMENT+EPITHELIUM+DERIVED+FACTOR+PEDF
4 PEDF R 181753 1% 100% 4 Search PEDF+R Search PEDF+R
5 EPC 1 145401 1% 80% 4 Search EPC+1 Search EPC+1
6 PIGMENT EPITHELIUM DERIVED FACTOR GENE 136315 0% 100% 3 Search PIGMENT+EPITHELIUM+DERIVED+FACTOR+GENE Search PIGMENT+EPITHELIUM+DERIVED+FACTOR+GENE
7 PIGMENT EPITHELIAL DERIVED FACTOR 132174 1% 36% 8 Search PIGMENT+EPITHELIAL+DERIVED+FACTOR Search PIGMENT+EPITHELIAL+DERIVED+FACTOR
8 PEDF RECEPTOR 90876 0% 100% 2 Search PEDF+RECEPTOR Search PEDF+RECEPTOR
9 12 15 HETES 45438 0% 100% 1 Search 12+15+HETES Search 12+15+HETES
10 44MER 45438 0% 100% 1 Search 44MER Search 44MER

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BECERRA, SP , NOTARIO, V , (2013) THE EFFECTS OF PEDF ON CANCER BIOLOGY: MECHANISMS OF ACTION AND THERAPEUTIC POTENTIAL.NATURE REVIEWS CANCER. VOL. 13. ISSUE 4. P. 258-271 135 80% 60
2 CRAWORD, SE , FITCHEV, P , VELICEASA, D , VOLPERT, OV , (2013) THE MANY FACETS OF PEDF IN DRUG DISCOVERY AND DISEASE: A DIAMOND IN THE ROUGH OR SPLIT PERSONALITY DISORDER?.EXPERT OPINION ON DRUG DISCOVERY. VOL. 8. ISSUE 7. P. 769 -792 145 76% 15
3 HE, XM , CHENG, R , BENYAJATI, S , MA, JX , (2015) PEDF AND ITS ROLES IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS: IMPLICATION IN DIABETIC AND HYPOXIA-INDUCED ANGIOGENIC DISEASES.CLINICAL SCIENCE. VOL. 128. ISSUE 11. P. 805 -823 95 74% 6
4 BELKACEMI, L , ZHANG, SX , (2016) ANTI-TUMOR EFFECTS OF PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF): IMPLICATION FOR CANCER THERAPY. A MINI-REVIEW.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. VOL. 35. ISSUE . P. - 93 67% 0
5 FRANCO-CHUAIRE, ML , RAMIREZ-CLAVIJO, S , CHUAIRE-NOACK, L , (2015) PIGMENT EPITHELIUM-DERIVED FACTOR: CLINICAL SIGNIFICANCE IN ESTROGEN-DEPENDENT TISSUES AND ITS POTENTIAL IN CANCER THERAPY.IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. VOL. 18. ISSUE 9. P. 837 -855 96 62% 1
6 YAMAGISHI, S , MATSUI, T , (2014) PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) AND CARDIOMETABOLIC DISORDERS.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 14. P. 2377 -2386 85 62% 2
7 FILLEUR, S , NELIUS, T , DE RIESE, W , KENNEDY, RC , (2009) CHARACTERIZATION OF PEDF: A MULTI-FUNCTIONAL SERPIN FAMILY PROTEIN.JOURNAL OF CELLULAR BIOCHEMISTRY. VOL. 106. ISSUE 5. P. 769-775 54 87% 111
8 KAWAGUCHI, T , YAMAGISHI, SI , SATA, M , (2010) STRUCTURE-FUNCTION RELATIONSHIPS OF PEDF.CURRENT MOLECULAR MEDICINE. VOL. 10. ISSUE 3. P. 302-311 77 62% 25
9 HAN, J , GUO, J , (2015) CURRENT EVIDENCE AND POTENTIAL MECHANISMS OF THERAPEUTIC ACTION OF PEDF IN CERVICAL CANCER TREATMENT.CURRENT MOLECULAR MEDICINE. VOL. 15. ISSUE 5. P. 446 -455 59 68% 3
10 BARNSTABLE, CJ , TOMBRAN-TINK, J , (2004) NEUROPROTECTIVE AND ANTIANGIOGENIC ACTIONS OF PEDF IN THE EYE: MOLECULAR TARGETS AND THERAPEUTIC POTENTIAL.PROGRESS IN RETINAL AND EYE RESEARCH. VOL. 23. ISSUE 5. P. 561-577 56 73% 114

Classes with closest relation at Level 2


Rank Class id link
1 2907 RETINOPATHY OF PREMATURITY//NORRIE DISEASE//OXYGEN INDUCED RETINOPATHY
2 104 OPHTHALMOLOGY//OPHTHALMOL//AGE RELATED MACULAR DEGENERATION
3 1179 ADVANCED GLYCATION END PRODUCTS//METHYLGLYOXAL//GLYCATION
4 361 ANGIOGENESIS//ENDOSTATIN//VEGF
5 266 RETINITIS PIGMENTOSA//OPHTHALMOLOGY//RETINA
6 3283 MECHANISMS OF AGEING AND DEVELOPMENT//EXPERIMENTAL GERONTOLOGY//CELLULAR AGING
7 3458 MASPIN//TAFI//THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR
8 1073 VITRECTOMY//MACULAR HOLE//OPHTHALMOLOGY
9 1574 TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN
10 2899 OCULAR DRUG DELIVERY//OPHTHALMIC DRUG DELIVERY//OCULAR DELIVERY

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