Tag Archives: molecular techniques in life science

Course Review: High-throughput data analysis

The course, BB2491 High-throughput data analysis, is the core of MTLS education at KTH. How does BB2491 differ from traditional biology lectures that we have so far? In this blog I will talk a bit about why, and how we should learn and master high-throughput science!

First, why study high-throughput? It is involved in a myriad of industrial applications, as well as the frontiers of research, to name but a few:

  • Next Generation Sequencing (NGS) is the best illustration of generating and analysing high-throughput data
  • High-throuput compound screening dominates lead discovery for manufacturing of small molecule drug
  • Traditional gene-targeting methods are sufficient for analysis of mendelian diseases, but diseases that involves more complex interplay, requires collecting and analysing “bigger data”

In BB2491, the teaching follows a logical transition from theory, practice to a hand-on project.

THEORY

In biology, high throughput analysis can be split into three parts, namely Genomics, Transcriptomics, and Proteomics. Correspondingly, we have three professors responsible for each part:

        

Lukas Käll                                Lars Arvestad                               Olof Emanuelsson

In contrast to traditional biology lectures, we have no designated text book; alternatively, we have 33 research papers or scientific reviews as mandatory reading materials! It sounds a bit daunting in the beginning, but under the careful guidance of teachers, as well as  fundamental building blocks in previous course (Genomics, Proteomics, Bioinformatics), we are able to dive into the ocean of knowledge!

For example, while Olof introduced the basic concept of RPKM in abundance estimation at the start of the transcriptomics part, it is concluded by four excellent students at the edge of RNA sequencing techniques.

COMPUTER LAB

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Who studies at MTLS? | Statistics of the admitted students

Recently, I received a lot of questions. Many of them look like these: “I study XXX, I want to know if I am eligible to be considered by MTLS? ” or “Are there any current MTLS students who come from YYY, just like me?” In this blog, you are going to find out more about the admitted MTLS students, regarding their demographic profile and academic background, that you CAN’T even get from our official website!

By 2017, there are in total 3 cohorts of students admitted into our programme.

CITIZENSHIP

A purple dot on the map represents the citizenship of one student. The number of students and diversity grow by years.

GENDER

The number of male and female in all three cohorts are roughly equal. Of course, you may notice that gender equality is a fundamental policy in all Swedish universities. In the admission process, no weight will be added/reduced based on gender of the applicant.

ACADEMIC BACKGROUND

It has been told that life science will be an interdisciplinary field; MTLS is no exception. The majors listed in the pie chart are based on the bachelor degree that the students possess:

2016

2017

 

Want to know more about our programme? There are numerous routes:

  1. Our four official websites at KTH, Karolinska Institute, Stockholm University and Science For Life Laboratory
  2. Follow my page MSc Molecular Techniques in Life Science
  3. Subscribe to my blog and get a weekly notification of the newest post!
  4. Contact our student ambassadors: me, Carolina at Karolinska or Javier at KTH!

Updated MTLS Course List

MTLS Molecular Techniques in Life Science has just updated its course list for incoming students in Fall 2018. Make sure to have a look at the list before submitting your application!

Green: new courses

Blue: modified courses (compared with 2016 cohort)

  • Genetics (5.0 hp)
  • Frontiers in Translational Medicine (16.5 hp)
  • Applied Communication (7.0 hp)
  • Applied Programming for Life Science I (1.5 hp)

For detailed description (unofficial and from a personal perspective) of the courses, you may take a look my previous blog about Genetics, Applied Communication and Frontiers in Translational Medicine. (Bear in mind that they may or may not correspond to the updated course content)

  • Bioinformatics (7.0 hp)
  • Methods in Molecular Life Science (7.0 hp)
  • Structure and Dynamics of Biological Membranes (7.0 hp)
  • Comparative Genomics (7.5 hp)
  • Applied Programming for Life Science II (1.5 hp)

Same, you might find Carolina, our best ambassador at Karolinska Institute’s blog very useful for preparing Methods in Molecular Life Science. I also wrote about the Bioinformatics and the predecessor of Structure and Dynamics of Biological Membranes in my previous blog.

Here is Carolina’s blog at KI website: /carolinasavatierdupre/

  • Applied Gene Technology and Large-scale Data Analysis (7.5 hp)
  • Clinical Applications of Biotechnology (6.0 hp)
  • Applied Programming for Life Science III (1.5 hp)

Choose 2 courses out of 3

  • Systems Biology (7.5 hp)
  • Drug Development (7.5 hp)
  • Project in Molecular Life Science (7.5 hp)

  • Master’s Dissertation (30 hp)

Want more information (something unique, something fun) about our programme?

 

MTLS welcomes the third cohort of students

Starting from this September, these 24 talented young people becomes the third “generation” of the family MSc Molecular Techniques in Life Science.

The number of new members rockets from 6 in year 2015, to 19 in year 2016, then this year we have 24!

MTLS Class 2015

MTLS Class  2016

MTLS Class 2017

On Wednesday, my classmates first met and fikad with the third cohort students —— without any exception, they are a amalgamate of ambitious, acquisitive and energetic “scientists in training”.

Here I would like to express thousands of thanks to my classmates Dimitri, who convened all of us with his passion and hospitality. Also, the statistics about their academic background will be posted here later, in favor of the potential applicants of our program.

Finally, my sincerest wish to the new students: the upcoming two years at MTLS will be definitely one of worthiest investment in your life 😉

Summer in Research: interview with 7 students working at SciLifeLab

Vacation is not the only option for summer; a number of students from my program Molecular Techniques in Life Science make an alternative decision: a two-month, full-time research internship at Science For Life Laboratory in Stockholm. Among them, a large portion belongs to the annual SciLifeLab Summer Fellow Program (description at end end of this blog), while the rest devote themselves into individual research project.

Now, after spending one month pipetting, culturing tissue or even sitting in front of a computer doing simulation, can they eventually integrate their knowledge from classroom to bench-top, and convert their passion in science to fruitful results in lab? Let’s have a chat with them about their job, their happiness and frustration, pain and gain during their unique summer in research!

 Dimitri Wirjowerdojo, Indonesia

 LinkedIn | dawir@kth.se  

Group: Håkan Jönsson (Nanobiotechnology and Proteomics at KTH)

Project: Droplet microfluidics processing in single-cell gene expression analysis

Xueqing Wang, China

LinkedIn | wangicesunny@163.com

Group: Erik Lindahl (Biophysics at KTH and Stockholm University)

Project: Engineering anesthetic sensitivity via an allosteric transmembrane cavity in pentameric ligand-gated ion channels

Javier Arroyo Gomez, Spain

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