Research program 3

Generation of a protein resource for drug development

Program number 3 involves the world's largest effort to generate all the human secreted proteins and selected cell surface proteins. Together these two classes of molecules constitute more than 80% of the protein targets for biological drugs on the market and in clinical trials. However, only a small fraction of this “druggable proteome” is currently used as targets for biological drugs and there is therefore a great need to explore these two classes of molecules further. The aim of program 3 is thus to produce the majority of all secreted proteins and selected extracellular domains (ECD) of the membrane-associated proteins in mammalian cells. A protein production pipeline for this purpose has already been established within the Wallenberg Center for Protein Research (WCPR) that started at KTH in January 2016. This pipeline will now also be used for protein production within program 3 of CellNova. The produced proteins will then be used by the industrial partners to develop different assays, validate targets and selection of new binders.

Project leader program 3:

Hanna Tegel, PhD and Group leader. Hanna Tegel is a group leader at KTH since 2009 and her main focus is recombinant protein production. Currently Hanna is heading the production of the Human Secretome project within the Wallenberg Center for Protein Research (WCPR) and in parallel she is the Site Director of the Human Protein Atlas project at AlbaNova University Centre.

Academia:
Sophia Hober
Sarah Lindbo
Marit Möller

Industrial partners:
Ulrika Qundos, Atlas Antibodies
Niklas Hagberg, Olink
Anna Sandegren, Affibody
Lovisa Holmberg Schiavone and Melanie Dannemeier, AstraZeneca

A protein resource for drug discovery.pdf (pdf 900 kB)