Adbiopro Distinguished Lecture: "Next Generation CHO"
With detailed sequence information now available for the most important production cell line for biopharmaceutics and new tools that enable efficient engineering approaches, the environment for Chinese Hamster Ovary (CHO) cell research and optimization has significantly changed over the last few years. The combination of computational prediction of cell behavior and efficient testing of multiplexed engineering strategies will thus lead to the next generation of cell lines with enhanced properties and capabilities
Time: Tue 2018-05-22 13.00
Lecturer: Prof. Nicole Borth, University of Vienna
Nicole Borth, PhD (Biotechnology, University of Life Sciences Vienna, Austria 1991), is Professor of Cell Biology and Cytometry at the Department of Biotechnology, University of Life Sciences Vienna (BOKU) and Area Leader in the Austrian Center of Industrial Biotechnology ACIB.
Her research aims at obtaining a comprehensive understanding of the molecular machinery that enables mammalian cells to be good production factories for biotherapeutic proteins. This includes factors that contribute to high yield based on productivity and growth, but also to protein quality attributes.
Using methods such as genomics, transcriptomics, flow cytometry / cell sorting and computational biology, her group aims at dissecting the molecular basis and regulation of process and quality relevant cellular properties. Nicole is a co-chair of CHOgenome , a non-profit organization that makes genome scale information for CHO cells publicly available.