AIMES - Crossing Borders with Thomas Brunner
“Extra-adrenal glucocorticoid synthesis in the intestinal mucosa: implications for local immune homeostasis and cancer development”
Biochemical Pharmacology, Dept. Biology, University of Konstanz, Germany
Register for the webinar and we will send you the meeting ID for Zoom via email.
Host: Onur Parlak
AIMES - Center for the Advancement of Integrated Medical and Engineering Sciences
Time: Tue 2022-04-12 15.00 - 16.00
Location: Zoom (sign-up required)
We are happy to welcome Thomas Brunner to give a talk with the following abstract:
Glucocorticoids as medical drugs have an important application in the treatment of inflammatory diseases and cancer. Seventy years ago, glucocorticoids were, however, first discovered as endogenous stress hormones, primarily produced by the adrenal glands in response to emotional, physical and immunological stress. Recent years have led to the discovery and characterization of alternative sources of these immunoregulatory steroid hormones. Our group discovered for the first-time glucocorticoid synthesis in the intestinal mucosa in response to immunological stress. In this presentation I will discuss the transcriptional regulation of intestinal steroidogenesis, its implication in the regulation of inflammatory processes of the intestine, and how colorectal tumors have high-jacked glucocorticoid synthesis to evade destruction by the immune system.