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Stefanie Reese's KEYNOTE seminar "Multi-physics modeling of in-stent restenosis: theoretical aspects and finite element implementation"

Time: Wed 2021-11-24 16.00

Location: zoom

Lecturer: Professor Stefanie Reese, RWTH Aachen University, Germany

Stefanie_Reese_Nov_24_2021.pdf (pdf 205 kB)

Abstract. Percutaneous coronary intervention (PCI) is a minimally invasive procedure wherein the plaque built up within the coronary arteries as part of an inflammatory pathosis termed atherosclerosis is pressed against the arterial walls using balloon angioplasty, and subsequently, a supporting scaffold called a stent is placed to restore normal blood flow within the artery. Endothelial denudation and overstretch injuries caused during the PCI procedure kick start a myriad of signaling cascades within the arterial wall resulting in uncontrolled tissue growth, eventually recreating obstructions to the blood flow. The process is labeled in-stent restenosis and the mechanism associated is termed neointimal hyperplasia. An attempt is made herein to model the complex phenomenon of restenosis by tracking the pathophysiology’s significant contributors [1, 2]. These include the platelet-derived growth factor (PDGF) and the transforming growth factor (TGF)-β, which are released into the arterial wall post platelet aggregation and degranulation. Additionally, the evolutions of the extracellular matrix and the smooth muscle cells are tracked since the local smooth muscle cell densities define the growth kinematics, and the local collagen concentrations in the extracellular matrix alter the compliance of the wall. A fully coupled multi-physical finite element system is hence set up that can provide insights with enough fidelity to adapt PCI parameters and alleviate the risks associated with restenosis [3].

[1] Budu-Grajdeanu, et al. Theor. Biol., 5:2, 2008.

[2] Escuer, et al. J. R. Soc. Interface, 16:20190313, 2019.

[3] Manjunatha, et al. (in press).

[4] DFG project meeting, 2021

Page responsible:Kommunikation SCI
Belongs to: KTH Solid Mechanics seminar series
Last changed: Nov 14, 2021