Molecular epigenetics and neuro degeneration
Molecular complexes involved in epigenetic modifications are being studied. The overall aim is to understand how these structures govern actions in systems, balanced under normal circumstances, but strongly affecting diseases such as cancer and neurodegenerative disorders.
The structural information will be merged with results from complementary studies such as activity measurements and proteomics to elucidate structure – function relationships. A natural progression of the project is to study the effects of drug candidates.
The project is a collaboration with a structural biology group at the Korean Advanced Institute of Science and Technology (PI: Ji-Joon Song).