Characterization and biointeractions of contrast agents for multimodal imaging
The next generation of contrast agents has to meet the criteria of working as a multimodal imaging device, combining different imaging techniques, such as ultrasound, magnetic resonance imaging (MRI) and single-photon emission computer tomography (SPECT). A modified poly vinyl alcohol (PVA) microbubble (MB), that includes super paramagnetic iron oxide nanoparticles (SPION) embedded in the shell, can work as both ultrasound and MRI contrast agent. Transmission electron microscopy has been used to study the structure of the MBs and confirm the binding ability of SPION. We are also characterizing the bio-interactions of these MBs.