The structure of molecular chaperones

Unfolding proteins are prevented from irreversible aggregation by small heat shock proteins (sHsps) through interactions that depend on a dynamic equilibrium between sHsp subunits and sHsp oligomers. By single-particle electron microscopy, homology modeling, and lysine-specific chemical crosslinking we have obtained a structure model of Arabidopsis thaliana Hsp21. Continued work is directed towards improving resolution of this and other chaperons.


Page responsible:Kenneth Carlsson
Belongs to: Structural Biotechnology
Last changed: Sep 12, 2018