Synthesis and applications of nanodiscs for nanobiotechnology applications
Over the past decade, discoidal reconstituted High Density Lipoprotein (HDL) particles (nanodiscs) have been utilized for applications beyond its physiological role in lipoprotein metabolism. We are both studying constructs of natural HDL and nanodiscs. In the latter case they can be used as small planar lipid bilayers allowing insertion and stabilization of transmembrane proteins for functional and structural studies. So far, most of our work has been focused on formation of protein complexes reported to be of importance for biosynthesis of mediators of pain, fever and inflammation (see above). However, we can foresee a large number of usages related to several of our projects and also a translation to applications as drug carriers for targeted therapy.
Contact person: Dr. Caroline Jegerschöld