Harriet Nilsson



Room number:7J 21: 12

E-mail to Harriet Nilsson

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Research interests

The gel forming mucins, MUC2 (intestine), MUC5AC (airways, stomach), MUC6 (stomach) and MUC5B (airways), form a protective epithelial barrier tightly regulated. They all have large sizes with heavily glycosylated mucin domains in the central part. The N- and C-terminal regions are important for oligomerization.

Our results have revealed the mechanism behind how MUC2, through its N-terminal, builds up a protective mucus layer in intestine. Due to high evolutionary similarities we now use the above knowledge performing structural studies on MUC6 and MUC5AC and MUC5B.

One of the goals of the project is to on molecular level understand how the extremely viscous mucus is formed in Cystic fibrosis. Solving this problem will give big advantages in the treatment of the disease and may result in a “simple” and common therapy for more than 1900 pathogenic mutations. Learn more about this project

Academic degrees

2009, PhD, Medical Science Dept. of Medical Cell Biology Uppsala University, Sweden. Thesis: Studies of Tight Junctions and Airway-Surface Liquid in Airway Epithelium with relevance to Cystic Fibrosis

2006, Medical licentiate, Medical Science Dept. of Medical Cell Biology Uppsala University, Sweden. Thesis: Studies of Airway-Surface Liquid and Tight Junctions in Airway Epithelium

2004, Master (M.Sc.), The Program of Mathematics and Science, Biology with 90 p chemistry included, Uppsala University, Sweden. Thesis: Determination of Ion Composition in Airway Surface Liquid by X-ray Microanalysis.

1989, Pedagogical Exam (cello), Conservatory of Arhus, Denmark

1987, Master (cello), Conservatory of Arhus, Denmark


Post doc. Dept of Bioscience and Nutrition, Karolinska Institutet, Huddinge, 2010

Graduate student, Dept. of Medical Cell Biology, Uppsala University 2004-2009

Cellist (musician and pedagogue) Sweden, Denmark, Norway, Poland 1984-1998

External Research Grants

Erica Lederhausen`s Foundation (post doc position) 2009
Swedish Cystic Fibrosis Association Research Fund and Anders Malmsten`s Foundation (post doc position), 2009

Heart and Lung Foundation (travel), 2009

Swedish Foundation for Cystic Fibrosis, Cecilia Falkmans foundation (travel) 2008

Heart and Lung Foundation (travel), 2008

North American CF Conference (NACFC) (travel), 2007

Heart and Lung Foundation (travel), 2007

Gillbergs Foundation (material), 2007

EuroCareCF(WP7) (travel), 2007

Agnes and Mac Rudbergs Foundation (founding first year as PhD student), 2004

Teaching Experience

Lecturer, Stockholm College of Osteopathic Medicine (SCOM) 2009

Course leader and organizer of Human Anatomy: biomedical students 1th year, 2006-2008

Teaching Assistant Dept. Medical Cell Biology, Uppsala university: 2005-2009

Ultrastructure (Electron Microscopy) medical students 2nd year
Human Anatomy as a part of:
- the Course of Neural Regulation and Motion for medical students 2nd year
- the Course of Circulation and Respiration for medical students 1st year,
- the Course of Physiology for pharmacy students 1st year
- the Course of Functional Morphology for Biomedical students 1st.

Histology as a part of:
- Clinical Anatomy for nurses, biomedical, pharmaceutical, and medical students 1st and 2nd year

International and National Lectures and Poster Presentation

Tällberg, Structural Biology Network (SBnet), Sweden (oral) 2010

Stockholm, Scandinavian Society for Electron Microscopy (Scandem), Sweden (poster) 2010

Uppsala: CFTR and Tight junctions in airway epithelium Uppsala Academic Hospital, Sweden (seminar, invited) 2009

Brest, 32th European Cystic Fibrosis Society (ECFS) Conference, France (oral) 2009

Berlin,European Respiratory Society (ERS) Conference, Germany (poster) 2008

Douro, EuroCareCF Conference, Portugal (poster) 2008

Anaheim North American Cystic Fibrosis Conference (NACFC), USA (poster) 2007

Copenhagen 29th European Cystic Fibrosis Society (ECFS) Conference, Denmark (poster) 2006

Popular science presentations (invited):
- Reports from Anaheim, North American Cystic Fibrosis Conference
- (NACFC) Riksförbundet Cystisk Fibros, 2008
- Mechanism behind PCD, Riksförbundet Cystisk Fibros 40 year anniversary, 2009

Training Workshops

Scandem Specimen preparation for immuno-EM and cryo-EM 2010

Uppsala University Pedagogical course for teachers at the university, Sweden 2009

Bristol University (Learning Ussing chamber technique), United Kingdom 2008

Lisboa University, Training Workshops of EuroCareCF(WP7), Portugal 2007

Page responsible:Kenneth Carlsson
Belongs to: Structural Biotechnology
Last changed: Sep 07, 2015