SK3510 Cellular Biophysics I 8.0 credits

Den biologiska cellens fysik I

The course covers the transport functions of biological cells from a physical perspective.

  • Educational level

    Third cycle
  • Academic level (A-D)

    D
  • Subject area

  • Grade scale

Information for research students about course offerings

Study period 3.

Intended learning outcomes

The main purpose of the course is to give the students practical tools to describe the transport properties of biological cells.
After the course the participants should be able to:

  • understand which molecules can be transported across cellular membranes and which mechanisms are used for the transport
  • choose the relevant mathematical models to describe the transport of water, ions and solutes within cells and through the cellular membranes
  • predict how water and ion homeostasis of the cells, as well as the membrane potential, are affected by the cell microenvironment
  • in their research projects, set up microscopy based measurements of biophysical parameters in living cells and analyze the real measurement data

Course main content

Transport within the cells and across the cell membranes. Transport of solutes and water, concurrent transport, carrier-mediated transport, transport of ions. Membrane potential. Cellular homeostasis. Measurement techniques for biophysical parameters.

Disposition

Lectures: 18 h
Laboratory exercises: 24 h
Seminar: 4 h

Eligibility

Enrolled PhD student.

Recommended prerequisites

SK3530 (Introduction to Biomedicine) and SK3500 (Physics of Biomedical Microscopy) are recommended.

Literature

Weiss T. F. Cellular Biophysics, volume 1, MIT Press, 1996

Examination

The course is examined by a written exam (TEN1; 4.0 university credits, grading P/F), a hand-in assignment (INL1; 1.5 university credits, grading P/F), written lab reports (LAB1; 1.5 university credits, grading P/F) and a presentation at a seminar (SEM1; 1.0 university credits, grading P/F).

Requirements for final grade

INL1 - hand-in assignment, 1.5 university credits, grading P/F.
LAB1 - laborations, 1.5 university credits, grading P/F.
SEM1 - seminar, 1.0 university credits, grading P/F.
TEN1 - written exam, 4.0 university credits, grading P/F.

Offered by

SCI/Applied Physics

Contact

Marina Zelenina, marinaz@kth.se

Examiner

Hjalmar Brismar <brismar@kth.se>

Version

Course syllabus valid from: Autumn 2014.