Class information for:
Level 1: CHLORZOXAZONE//CYP2E1//6 HYDROXYCHLORZOXAZONE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10357 1070 37.6 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
10357 1                   CHLORZOXAZONE//CYP2E1//6 HYDROXYCHLORZOXAZONE 1070

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHLORZOXAZONE authKW 611830 5% 40% 53
2 CYP2E1 authKW 364210 9% 14% 94
3 6 HYDROXYCHLORZOXAZONE authKW 177797 1% 69% 9
4 CYTOCHROME P450 2E1 authKW 129293 3% 12% 37
5 P NITROPHENOL HYDROXYLATION authKW 85608 0% 100% 3
6 P450 2E1 authKW 82539 1% 32% 9
7 ANILINE 4 HYDROXYLASE authKW 65222 0% 57% 4
8 ETHANOL INDUCIBLE CYTOCHROME P450 authKW 57072 0% 100% 2
9 MICROSOMAL ETHANOL OXIDIZING SYSTEM authKW 45653 0% 40% 4
10 CYP2E1 MRNA authKW 38047 0% 67% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 5380 42% 0% 448
2 Toxicology 4240 19% 0% 206
3 Substance Abuse 1070 5% 0% 52
4 Biophysics 868 11% 0% 120
5 Biochemistry & Molecular Biology 835 26% 0% 281
6 Gastroenterology & Hepatology 33 3% 0% 27
7 Chemistry, Medicinal 32 2% 0% 26
8 Biochemical Research Methods 25 3% 0% 28
9 Endocrinology & Metabolism 22 3% 0% 33
10 Oncology 21 5% 0% 49

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KUKK RD LTD 38047 0% 67% 2
2 AGOURON 28536 0% 100% 1
3 ANAL CHEM TOXICOL BROMATOL 28536 0% 100% 1
4 BIOCHEM 1 GUSTAVE L LEVY PL 28536 0% 100% 1
5 BIOMED SCI CHEM CARCINOGENESIS PHARMAC 28536 0% 100% 1
6 BRONX VA MED 151 2 28536 0% 100% 1
7 COORDINAC NACL SALUD TRABAJO 28536 0% 100% 1
8 DRUG MATAB CLIN PHARMACOKINET 28536 0% 100% 1
9 EA 2199 28536 0% 100% 1
10 EA 859 28536 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEMICAL PHARMACOLOGY 13307 9% 1% 93
2 XENOBIOTICA 7985 3% 1% 33
3 DRUG METABOLISM AND DISPOSITION 7647 4% 1% 45
4 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 3864 3% 0% 33
5 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 3810 4% 0% 48
6 ARCHIVES OF TOXICOLOGY 2339 2% 0% 19
7 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 1903 4% 0% 38
8 TOXICOLOGY LETTERS 1774 2% 0% 23
9 CHEMICO-BIOLOGICAL INTERACTIONS 1111 1% 0% 15
10 EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION 1047 0% 1% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CHLORZOXAZONE 611830 5% 40% 53 Search CHLORZOXAZONE Search CHLORZOXAZONE
2 CYP2E1 364210 9% 14% 94 Search CYP2E1 Search CYP2E1
3 6 HYDROXYCHLORZOXAZONE 177797 1% 69% 9 Search 6+HYDROXYCHLORZOXAZONE Search 6+HYDROXYCHLORZOXAZONE
4 CYTOCHROME P450 2E1 129293 3% 12% 37 Search CYTOCHROME+P450+2E1 Search CYTOCHROME+P450+2E1
5 P NITROPHENOL HYDROXYLATION 85608 0% 100% 3 Search P+NITROPHENOL+HYDROXYLATION Search P+NITROPHENOL+HYDROXYLATION
6 P450 2E1 82539 1% 32% 9 Search P450+2E1 Search P450+2E1
7 ANILINE 4 HYDROXYLASE 65222 0% 57% 4 Search ANILINE+4+HYDROXYLASE Search ANILINE+4+HYDROXYLASE
8 ETHANOL INDUCIBLE CYTOCHROME P450 57072 0% 100% 2 Search ETHANOL+INDUCIBLE+CYTOCHROME+P450 Search ETHANOL+INDUCIBLE+CYTOCHROME+P450
9 MICROSOMAL ETHANOL OXIDIZING SYSTEM 45653 0% 40% 4 Search MICROSOMAL+ETHANOL+OXIDIZING+SYSTEM Search MICROSOMAL+ETHANOL+OXIDIZING+SYSTEM
10 CYP2E1 MRNA 38047 0% 67% 2 Search CYP2E1+MRNA Search CYP2E1+MRNA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LIEBER, CS , (1997) CYTOCHROME P-4502E1: ITS PHYSIOLOGICAL AND PATHOLOGICAL ROLE.PHYSIOLOGICAL REVIEWS. VOL. 77. ISSUE 2. P. 517-544 110 43% 562
2 NOVAK, RF , WOODCROFT, KJ , (2000) THE ALCOHOL-INDUCIBLE FORM OF CYTOCHROME P450 (CYP2E1): ROLE IN TOXICOLOGY AND REGULATION OF EXPRESSION.ARCHIVES OF PHARMACAL RESEARCH. VOL. 23. ISSUE 4. P. 267 -282 85 62% 78
3 LIEBER, CS , (1999) MICROSOMAL ETHANOL-OXIDIZING SYSTEM (MEOS): THE FIRST 30 YEARS (1968-1998) - A REVIEW.ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. VOL. 23. ISSUE 6. P. 991 -1007 85 49% 237
4 RAUCY, JL , KRANER, JC , LASKER, JM , (1993) BIOACTIVATION OF HALOGENATED HYDROCARBONS BY CYTOCHROME-P4502E1.CRITICAL REVIEWS IN TOXICOLOGY. VOL. 23. ISSUE 1. P. 1-20 65 55% 168
5 YANG, CS , YOO, JSH , ISHIZAKI, H , HONG, JY , (1990) CYTOCHROME-P450IIE1 - ROLES IN NITROSAMINE METABOLISM AND MECHANISMS OF REGULATION.DRUG METABOLISM REVIEWS. VOL. 22. ISSUE 2-3. P. 147-159 41 82% 339
6 NEAFSEY, P , GINSBERG, G , HATTIS, D , JOHNS, DO , GUYTON, KZ , SONAWANE, B , (2009) GENETIC POLYMORPHISM IN CYP2E1: POPULATION DISTRIBUTION OF CYP2E1 ACTIVITY.JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. VOL. 12. ISSUE 5-6. P. 362-388 55 33% 47
7 WU, DF , CEDERBAUM, AI , (1993) COMBINED EFFECTS OF STREPTOZOTOCIN-INDUCED DIABETES PLUS 4-METHYLPYRAZOLE TREATMENT ON RAT-LIVER CYTOCHROME-P4502E1.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. VOL. 302. ISSUE 1. P. 175-182 38 88% 9
8 ERNSTGARD, L , JOHANSON, G , KARLSSON, AS , WARHOLM, M , (2007) PHENOTYPING OF CYTOCHROME P450 2E1 IN VITRO AND IN VIVO.CURRENT DRUG METABOLISM. VOL. 8. ISSUE 5. P. 493-498 26 72% 4
9 WU, DF , CEDERBAUM, AI , (1994) CHARACTERIZATION OF PYRAZOLE AND 4-METHYLPYRAZOLE INDUCTION OF CYTOCHROME P4502E1 IN RAT-KIDNEY.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 270. ISSUE 1. P. 407 -413 37 76% 17
10 WAN, J , ERNSTGARD, L , SONG, BJ , SHOAF, SE , (2006) CHLORZOXAZONE METABOLISM IS INCREASED IN FASTED SPRAGUE-DAWLEY RATS.JOURNAL OF PHARMACY AND PHARMACOLOGY. VOL. 58. ISSUE 1. P. 51-61 25 74% 11

Classes with closest relation at Level 1


Rank Class id link
1 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
2 22160 5 METHOXYTRYPTAMINE O DEMETHYLATION//BRAIN CYPS//BRAIN DRUG METABOLISM
3 2233 ALCOHOLIC LIVER DISEASE//HEPATOBIOL TOXICOL//CYP2E1
4 10981 N NITROSODIALKYLAMINE//N NITROSO N METHYLANILINE//IARC SCIENTIFIC PUBLICATIONS
5 18125 UNIT ACETALDEHYDE CANC//ALCOHOL DIS UNIT//ACETALDEHYDE
6 16328 CHLOROFORM//LOUISIANA TOXICOL//HEPATOCELLULAR REGENERATION
7 17643 ASAN FDN//AGROPHARMA//DA 125
8 27135 MICROSOMAL FATTY ACID COMPOSITION//SALMONELLA MUTAGENICITY SPIRAL ASSAY//AND DIETARY OILS
9 29933 BIOCHEMICAL ARCHIVES//ALCOHOLEMIA//ALPHA AMINO BUTYRIC ACID
10 25968 HUMAN S9//1 1 DIBROMOBENZENE//1 METHYL 2 ARYLETHYL HYDROXYLAMINE

Go to start page