Class information for:
Level 1: RETIGABINE//FLUPIRTINE//KCNQ

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10581 1051 41.1 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
11 3       ATRIAL FIBRILLATION//CARDIAC & CARDIOVASCULAR SYSTEM//CATHETER ABLATION 130936
691 2             POTASSIUM CHANNELS//BK CHANNEL//RETIGABINE 13105
10581 1                   RETIGABINE//FLUPIRTINE//KCNQ 1051

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RETIGABINE authKW 2519427 10% 80% 109
2 FLUPIRTINE authKW 1850112 8% 81% 79
3 KCNQ authKW 1820534 9% 67% 94
4 M CURRENT authKW 1789654 11% 56% 111
5 KCNQ2 authKW 1106465 4% 81% 47
6 LINOPIRDINE authKW 920573 4% 81% 39
7 KCNQ CHANNELS authKW 860781 4% 74% 40
8 KV7 authKW 764830 4% 71% 37
9 KV7 CHANNELS authKW 649263 3% 72% 31
10 M CHANNEL authKW 585718 2% 81% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 3199 33% 0% 348
2 Pharmacology & Pharmacy 2198 28% 0% 295
3 Clinical Neurology 1137 16% 0% 163
4 Physiology 981 11% 0% 119
5 Chemistry, Medicinal 286 6% 0% 59
6 Biochemistry & Molecular Biology 25 9% 0% 96
7 Cell Biology 20 4% 0% 47
8 Behavioral Sciences 19 1% 0% 15
9 Genetics & Heredity 16 3% 0% 33
10 Psychiatry 13 2% 0% 26

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEW LEADS BIOL 145260 0% 100% 5
2 ASTA MED GRP 118623 1% 58% 7
3 ION CHANNELS GRP 92965 0% 80% 4
4 ABT MED DEUT LAND 87156 0% 100% 3
5 CHILDREN NEUROL UNIT 58104 0% 100% 2
6 LEHRSTUHL BIOCHEM REZEPTORBIOCHEM 1 58104 0% 100% 2
7 SECT EARLY TARGET PHARMACOL PHYSIOL 58104 0% 100% 2
8 PHARMACOL CELL PHYSIOL GRP 51644 0% 44% 4
9 WELLCOME MOL PHARMACOL 42007 1% 16% 9
10 CNRSUMR 6150 38735 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EPILEPSY RESEARCH 4288 2% 1% 24
2 JOURNAL OF NEUROSCIENCE 3450 6% 0% 64
3 EPILEPSIA 3090 3% 0% 31
4 JOURNAL OF GENERAL PHYSIOLOGY 2510 2% 1% 17
5 JOURNAL OF PHYSIOLOGY-LONDON 2484 4% 0% 40
6 BRITISH JOURNAL OF PHARMACOLOGY 2073 3% 0% 36
7 CHANNELS 1379 0% 1% 5
8 MOLECULAR PHARMACOLOGY 1280 2% 0% 21
9 POSTGRADUATE MEDICAL JOURNAL 1090 2% 0% 17
10 GIORNALE DI GERONTOLOGIA 1036 0% 4% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RETIGABINE 2519427 10% 80% 109 Search RETIGABINE Search RETIGABINE
2 FLUPIRTINE 1850112 8% 81% 79 Search FLUPIRTINE Search FLUPIRTINE
3 KCNQ 1820534 9% 67% 94 Search KCNQ Search KCNQ
4 M CURRENT 1789654 11% 56% 111 Search M+CURRENT Search M+CURRENT
5 KCNQ2 1106465 4% 81% 47 Search KCNQ2 Search KCNQ2
6 LINOPIRDINE 920573 4% 81% 39 Search LINOPIRDINE Search LINOPIRDINE
7 KCNQ CHANNELS 860781 4% 74% 40 Search KCNQ+CHANNELS Search KCNQ+CHANNELS
8 KV7 764830 4% 71% 37 Search KV7 Search KV7
9 KV7 CHANNELS 649263 3% 72% 31 Search KV7+CHANNELS Search KV7+CHANNELS
10 M CHANNEL 585718 2% 81% 25 Search M+CHANNEL Search M+CHANNEL

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MALJEVIC, S , LERCHE, H , (2014) POTASSIUM CHANNEL GENES AND BENIGN FAMILIAL NEONATAL EPILEPSY.GENETICS OF EPILEPSY. VOL. 213. ISSUE . P. 17 -53 103 67% 13
2 WICKENDEN, AD , MCNAUGHTON-SMITH, G , (2009) KV7 CHANNELS AS TARGETS FOR THE TREATMENT OF PAIN.CURRENT PHARMACEUTICAL DESIGN. VOL. 15. ISSUE 15. P. 1773-1798 82 90% 29
3 DALBY-BROWN, W , HANSEN, HH , KORSGAARD, MPG , MIRZA, N , OLESEN, SP , (2006) K(V)7 CHANNELS: FUNCTION, PHARMACOLOGY AND CHANNEL MODULATORS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 6. ISSUE 10. P. 999-1023 117 66% 26
4 BROWN, DA , PASSMORE, GM , (2009) NEURAL KCNQ (KV7) CHANNELS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 156. ISSUE 8. P. 1185 -1195 60 80% 231
5 GREENE, DL , HOSHI, N , (2017) MODULATION OF KV7 CHANNELS AND EXCITABILITY IN THE BRAIN.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 74. ISSUE 3. P. 495 -508 97 59% 0
6 MICELI, F , SOLDOVIERI, MV , MARTIRE, M , TAGLIALATELA, M , (2008) MOLECULAR PHARMACOLOGY AND THERAPEUTIC POTENTIAL OF NEURONAL KV7-MODULATING DRUGS.CURRENT OPINION IN PHARMACOLOGY. VOL. 8. ISSUE 1. P. 65 -74 67 89% 64
7 JEPPS, TA , OLESEN, SP , GREENWOOD, IA , (2013) ONE MAN'S SIDE EFFECT IS ANOTHER MAN'S THERAPEUTIC OPPORTUNITY: TARGETING KV7 CHANNELS IN SMOOTH MUSCLE DISORDERS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 168. ISSUE 1. P. 19-27 63 85% 14
8 BARRESE, V , MICELI, F , SOLDOVIERI, MV , AMBROSINO, P , IANNOTTI, FA , CILIO, MR , TAGLIALATELA, M , (2010) NEURONAL POTASSIUM CHANNEL OPENERS IN THE MANAGEMENT OF EPILEPSY: ROLE AND POTENTIAL OF RETIGABINE.FRONTIERS IN PHARMACOLOGY. VOL. 2. ISSUE . P. 225 -236 69 81% 1
9 GRIBKOFF, VK , (2008) THE THERAPEUTIC POTENTIAL OF NEURONAL K(V)7 (KCNQ) CHANNEL MODULATORS: AN UPDATE.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 12. ISSUE 5. P. 565 -581 79 64% 27
10 GUNTHORPE, MJ , LARGE, CH , SANKAR, R , (2012) THE MECHANISM OF ACTION OF RETIGABINE (EZOGABINE), A FIRST-IN-CLASS K+ CHANNEL OPENER FOR THE TREATMENT OF EPILEPSY.EPILEPSIA. VOL. 53. ISSUE 3. P. 412 -424 46 81% 69

Classes with closest relation at Level 1


Rank Class id link
1 3699 DRAVET SYNDROME//SCN1A//GEFS
2 11634 SYMPATHETIC GANGLION CELLS//M CURRENT//NICOTINIC SYNAPSES
3 19178 LACOSAMIDE//ESLICARBAZEPINE ACETATE//PERAMPANEL
4 34927 REMACEMIDE//LOSIGAMONE//DESGLYCINYL REMACEMIDE
5 7179 DENDROTOXIN//EPISODIC ATAXIA TYPE 1//KCNA1
6 1859 LONG QT SYNDROME//KCNQ1//SHORT QT SYNDROME
7 16590 AXON INITIAL SEGMENT//NODE OF RANVIER//PARANODE
8 12462 SK CHANNELS//APAMIN//AFTERHYPERPOLARIZATION
9 15144 PAROXYSMAL KINESIGENIC DYSKINESIA//PRRT2//PAROXYSMAL DYSKINESIA
10 14468 K 2P CHANNELS//TREK 1//TWO PORE DOMAIN POTASSIUM CHANNEL

Go to start page