Class information for:
Level 1: HSP90//GELDANAMYCIN//HSP90 INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1212 2782 48.8 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
410 3       HEAT SHOCK PROTEIN//HSP90//HSP70 29410
290 2             HEAT SHOCK PROTEIN//HSP90//HSP70 18900
1212 1                   HSP90//GELDANAMYCIN//HSP90 INHIBITORS 2782

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HSP90 authKW 2712182 22% 41% 602
2 GELDANAMYCIN authKW 1236253 7% 55% 205
3 HSP90 INHIBITORS authKW 1200358 5% 71% 153
4 HEAT SHOCK PROTEIN 90 authKW 793839 7% 39% 185
5 17 AAG authKW 709091 4% 63% 102
6 CDC37 authKW 298370 2% 63% 43
7 RADICICOL authKW 257847 2% 50% 47
8 17 DMAG authKW 234341 1% 69% 31
9 CO CHAPERONE authKW 226681 2% 41% 50
10 CLIENT PROTEINS authKW 217962 1% 83% 24

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 5156 24% 0% 656
2 Biochemistry & Molecular Biology 4941 37% 0% 1024
3 Cell Biology 3732 20% 0% 559
4 Chemistry, Medicinal 3699 11% 0% 317
5 Pharmacology & Pharmacy 411 10% 0% 269
6 Chemistry, Organic 335 7% 0% 184
7 Biophysics 226 4% 0% 122
8 Hematology 119 3% 0% 79
9 Genetics & Heredity 82 4% 0% 105
10 Biochemical Research Methods 81 3% 0% 78

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC UK CANC THER EUT 113207 2% 22% 47
2 SIGNAL TRANSDUCT MOL PHARMACOL TEAM 92723 0% 65% 13
3 SECT STRUCT BIOL 88539 2% 19% 43
4 PROGRAM MOL PHARMACOL CHEM 81805 1% 23% 33
5 UROL ONCOL BRANCH 75505 3% 10% 70
6 HADDOW S 49841 1% 13% 36
7 PHARMACEUT OPT SPECT 43893 0% 67% 6
8 MOL BIOL COURSE 32923 0% 100% 3
9 GUANGZHOU JINAN BIOMED DEV 32233 0% 24% 12
10 PROT FOLDING GRP 29262 0% 67% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL STRESS & CHAPERONES 18684 2% 4% 44
2 MOLECULAR CANCER THERAPEUTICS 4919 2% 1% 43
3 CURRENT TOPICS IN MEDICINAL CHEMISTRY 3228 1% 1% 26
4 JOURNAL OF BIOLOGICAL CHEMISTRY 2829 7% 0% 207
5 CLINICAL CANCER RESEARCH 2656 2% 0% 61
6 CURRENT CANCER DRUG TARGETS 2570 1% 2% 15
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2206 3% 0% 73
8 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1595 1% 1% 26
9 JOURNAL OF MEDICINAL CHEMISTRY 1401 2% 0% 54
10 ADVANCES IN CANCER RESEARCH 1297 0% 1% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HSP90 2712182 22% 41% 602 Search HSP90 Search HSP90
2 GELDANAMYCIN 1236253 7% 55% 205 Search GELDANAMYCIN Search GELDANAMYCIN
3 HSP90 INHIBITORS 1200358 5% 71% 153 Search HSP90+INHIBITORS Search HSP90+INHIBITORS
4 HEAT SHOCK PROTEIN 90 793839 7% 39% 185 Search HEAT+SHOCK+PROTEIN+90 Search HEAT+SHOCK+PROTEIN+90
5 17 AAG 709091 4% 63% 102 Search 17+AAG Search 17+AAG
6 CDC37 298370 2% 63% 43 Search CDC37 Search CDC37
7 RADICICOL 257847 2% 50% 47 Search RADICICOL Search RADICICOL
8 17 DMAG 234341 1% 69% 31 Search 17+DMAG Search 17+DMAG
9 CO CHAPERONE 226681 2% 41% 50 Search CO+CHAPERONE Search CO+CHAPERONE
10 CLIENT PROTEINS 217962 1% 83% 24 Search CLIENT+PROTEINS Search CLIENT+PROTEINS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 JACKSON, SE , (2013) HSP90: STRUCTURE AND FUNCTION.MOLECULAR CHAPERONES. VOL. 328. ISSUE . P. 155-240 209 56% 53
2 KHANDELWAL, A , CROWLEY, VM , BLAGG, BSJ , (2016) NATURAL PRODUCT INSPIRED N-TERMINAL HSP90 INHIBITORS: FROM BENCH TO BEDSIDE?.MEDICINAL RESEARCH REVIEWS. VOL. 36. ISSUE 1. P. 92 -118 127 78% 6
3 TREPEL, J , MOLLAPOUR, M , GIACCONE, G , NECKERS, L , (2010) TARGETING THE DYNAMIC HSP90 COMPLEX IN CANCER.NATURE REVIEWS CANCER. VOL. 10. ISSUE 8. P. 537 -549 102 65% 568
4 SOLAROVA, Z , MOJZIS, J , SOLAR, P , (2015) HSP90 INHIBITOR AS A SENSITIZER OF CANCER CELLS TO DIFFERENT THERAPIES.INTERNATIONAL JOURNAL OF ONCOLOGY. VOL. 46. ISSUE 3. P. 907 -926 161 66% 8
5 KHAN, S , BOURBOULIA, D , TREPEL, JB , NECKERS, L , MOLLAPOUR, M , WALTON-DIAZ, A , (2013) CONTRIBUTIONS OF CO-CHAPERONES AND POST-TRANSLATIONAL MODIFICATIONS TOWARDS HSP90 DRUG SENSITIVITY.FUTURE MEDICINAL CHEMISTRY. VOL. 5. ISSUE 9. P. 1059 -1071 123 92% 20
6 WHITESELL, L , LINDQUIST, SL , (2005) HSP90 AND THE CHAPERONING OF CANCER.NATURE REVIEWS CANCER. VOL. 5. ISSUE 10. P. 761-772 95 69% 1223
7 LI, J , SOROKA, J , BUCHNER, J , (2012) THE HSP90 CHAPERONE MACHINERY: CONFORMATIONAL DYNAMICS AND REGULATION BY CO-CHAPERONES.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1823. ISSUE 3. P. 624-635 129 64% 123
8 PRATT, WB , TOFT, DO , (2003) REGULATION OF SIGNALING PROTEIN FUNCTION AND TRAFFICKING BY THE HSP90/HSP70-BASED CHAPERONE MACHINERY.EXPERIMENTAL BIOLOGY AND MEDICINE. VOL. 228. ISSUE 2. P. 111-133 149 51% 908
9 MATTS, RL , MANJARREZ, JR , (2009) ASSAYS FOR IDENTIFICATION OF HSP90 INHIBITORS AND BIOCHEMICAL METHODS FOR DISCRIMINATING THEIR MECHANISM OF ACTION.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 15. P. 1462-1478 149 82% 8
10 LI, YY , ZHANG, T , SCHWARTZ, SJ , SUN, DX , (2009) NEW DEVELOPMENTS IN HSP90 INHIBITORS AS ANTI-CANCER THERAPEUTICS: MECHANISMS, CLINICAL PERSPECTIVE AND MORE POTENTIAL.DRUG RESISTANCE UPDATES. VOL. 12. ISSUE 1-2. P. 17-27 129 79% 78

Classes with closest relation at Level 1


Rank Class id link
1 29664 SORCIN//TRAP1//HAISHENGSU
2 6152 DNAJ//DNAK//GRPE
3 17983 BAG 1//BAG3//DR H BLISS MURPHY CANC
4 5282 HSP27//HEAT SHOCK PROTEIN 27//HEAT SHOCK PROTEIN
5 21849 RESORCYLIC ACID LACTONES//LASIODIPLODIN//HYPOTHEMYCIN
6 9533 HSF1//HEAT SHOCK FACTOR//HEAT SHOCK FACTOR 1
7 21777 ANSAMITOCINS//ACTINOSYNNEMA PRETIOSUM//TRIENE ANSAMYCIN
8 8051 IMMUNOTHER Y CANC INFECT DIS//GP96//HEAT SHOCK PROTEIN
9 36244 ANTIBODIES CULTURE HEAT SHOCK PROTEIN//CDNA INSERTS//HSP 70 KDA HEAT SHOCK PROTEIN FAMILY
10 14348 HSP70//EMBRYOTOXICOL SECT//HEAT SHOCK PROTEIN

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