Class information for:
Level 1: IRON METAB CHELAT PROGRAM//PYRIDOXAL ISONICOTINOYL HYDRAZONE//MOL PHARMACOL PATHOL PROGRAM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12918 872 46.6 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
332 3       ERYTHROPOIETIN//ANEMIA//FERRITIN 37752
210 2             IRON OVERLOAD//HEPCIDIN//HEMOCHROMATOSIS 20783
12918 1                   IRON METAB CHELAT PROGRAM//PYRIDOXAL ISONICOTINOYL HYDRAZONE//MOL PHARMACOL PATHOL PROGRAM 872

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IRON METAB CHELAT PROGRAM address 882032 5% 55% 46
2 PYRIDOXAL ISONICOTINOYL HYDRAZONE authKW 663173 3% 76% 25
3 MOL PHARMACOL PATHOL PROGRAM address 492383 3% 47% 30
4 TRIAPINE authKW 482552 2% 66% 21
5 IRON CHELATOR authKW 376847 8% 15% 73
6 3 AP authKW 283629 1% 90% 9
7 DP44MT authKW 264803 1% 69% 11
8 3 AMINOPYRIDINE 2 CARBOXALDEHYDE THIOSEMICARBAZONE authKW 214472 1% 88% 7
9 SALICYLALDEHYDE ISONICOTINOYL HYDRAZONE authKW 155976 1% 64% 7
10 TRIAPINE R authKW 145899 1% 83% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 2274 28% 0% 240
2 Chemistry, Medicinal 646 9% 0% 76
3 Hematology 500 8% 0% 70
4 Pharmacology & Pharmacy 419 15% 0% 131
5 Chemistry, Inorganic & Nuclear 322 8% 0% 68
6 Biochemistry & Molecular Biology 319 20% 0% 172
7 Cell Biology 76 7% 0% 60
8 Toxicology 68 3% 0% 30
9 Medicine, Research & Experimental 45 4% 0% 34
10 Nutrition & Dietetics 39 2% 0% 21

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IRON METAB CHELAT PROGRAM 882032 5% 55% 46
2 MOL PHARMACOL PATHOL PROGRAM 492383 3% 47% 30
3 BO 116623 7% 5% 62
4 IRON METAB CHELAT GRP 113441 1% 36% 9
5 OXYRAD GRP 89630 1% 32% 8
6 RENAL INFECT DIS 80033 0% 57% 4
7 IRON METABOL CHELAT PROGRAM 70032 0% 100% 2
8 EDUC REGENERAT MED 46687 0% 67% 2
9 MET BIOL 43215 1% 11% 11
10 CYTOL EXPT CANCEROL 43091 0% 31% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 1723 1% 0% 10
2 BIOMETALS 1622 1% 1% 9
3 JOURNAL OF INORGANIC BIOCHEMISTRY 1569 2% 0% 16
4 CELL PROLIFERATION 987 1% 0% 6
5 MEDICAL ONCOLOGY AND TUMOR PHARMACOTHERAPY 970 0% 1% 3
6 JOURNAL OF MEDICINAL CHEMISTRY 755 3% 0% 22
7 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 715 1% 0% 10
8 MOLECULAR PHARMACOLOGY 680 2% 0% 14
9 FREE RADICAL BIOLOGY AND MEDICINE 667 1% 0% 13
10 CANCER RESEARCH 661 3% 0% 28

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PYRIDOXAL ISONICOTINOYL HYDRAZONE 663173 3% 76% 25 Search PYRIDOXAL+ISONICOTINOYL+HYDRAZONE Search PYRIDOXAL+ISONICOTINOYL+HYDRAZONE
2 TRIAPINE 482552 2% 66% 21 Search TRIAPINE Search TRIAPINE
3 IRON CHELATOR 376847 8% 15% 73 Search IRON+CHELATOR Search IRON+CHELATOR
4 3 AP 283629 1% 90% 9 Search 3+AP Search 3+AP
5 DP44MT 264803 1% 69% 11 Search DP44MT Search DP44MT
6 3 AMINOPYRIDINE 2 CARBOXALDEHYDE THIOSEMICARBAZONE 214472 1% 88% 7 Search 3+AMINOPYRIDINE+2+CARBOXALDEHYDE+THIOSEMICARBAZONE Search 3+AMINOPYRIDINE+2+CARBOXALDEHYDE+THIOSEMICARBAZONE
7 SALICYLALDEHYDE ISONICOTINOYL HYDRAZONE 155976 1% 64% 7 Search SALICYLALDEHYDE+ISONICOTINOYL+HYDRAZONE Search SALICYLALDEHYDE+ISONICOTINOYL+HYDRAZONE
8 TRIAPINE R 145899 1% 83% 5 Search TRIAPINE+R Search TRIAPINE+R
9 PROCHELATOR 109422 1% 63% 5 Search PROCHELATOR Search PROCHELATOR
10 2 BENZOYLPYRIDINE 4 ETHYL 3 THIOSEMICARBAZONE 105048 0% 100% 3 Search 2+BENZOYLPYRIDINE+4+ETHYL+3+THIOSEMICARBAZONE Search 2+BENZOYLPYRIDINE+4+ETHYL+3+THIOSEMICARBAZONE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MERLOT, AM , KALINOWSKI, DS , RICHARDSON, DR , (2013) NOVEL CHELATORS FOR CANCER TREATMENT: WHERE ARE WE NOW?.ANTIOXIDANTS & REDOX SIGNALING. VOL. 18. ISSUE 8. P. 973 -1006 103 35% 43
2 STEFANI, C , JANSSON, PJ , GUTIERREZ, E , BERNHARDT, PV , RICHARDSON, DR , KALINOWSKI, DS , (2013) ALKYL SUBSTITUTED 2 '-BENZOYLPYRIDINE THIOSEMICARBAZONE CHELATORS WITH POTENT AND SELECTIVE ANTI-NEOPLASTIC ACTIVITY: NOVEL LIGANDS THAT LIMIT METHEMOGLOBIN FORMATION.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 1. P. 357-370 45 88% 11
3 SHARPE, PC , BERNHARDT, PV , RICHARDSON, DR , YU, Y , KALINOWSKI, DS , KOVACEVIC, Z , SIAFAKAS, AR , JANSSON, PJ , STEFANI, C , LOVEJOY, DB , (2009) THIOSEMICARBAZONES FROM THE OLD TO NEW: IRON CHELATORS THAT ARE MORE THAN JUST RIBONUCLEOTIDE REDUCTASE INHIBITORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 52. ISSUE 17. P. 5271 -5294 71 44% 125
4 BUSS, JL , TORTI, FM , TORTI, SV , (2003) THE ROLE OF IRON CHELATION IN CANCER THERAPY.CURRENT MEDICINAL CHEMISTRY. VOL. 10. ISSUE 12. P. 1021-1034 79 45% 122
5 MARQUES, O , DA SILVA, BM , PORTO, G , LOPES, C , (2014) IRON HOMEOSTASIS IN BREAST CANCER.CANCER LETTERS. VOL. 347. ISSUE 1. P. 1 -14 91 29% 19
6 YU, Y , GUTIERREZ, E , KOVACEVIC, Z , SALETTA, F , OBEIDY, P , RAHMANTO, YS , RICHARDSON, DR , (2012) IRON CHELATORS FOR THE TREATMENT OF CANCER.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 17. P. 2689-2702 58 45% 52
7 LUKMANTARA, AY , KALINOWSKI, DS , KUMAR, N , RICHARDSON, DR , (2013) SYNTHESIS AND BIOLOGICAL EVALUATION OF SUBSTITUTED 2-BENZOYLPYRIDINE THIOSEMICARBAZONES: NOVEL STRUCTURE-ACTIVITY RELATIONSHIPS UNDERPINNING THEIR ANTI-PROLIFERATIVE AND CHELATION EFFICACY.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 23. ISSUE 4. P. 967 -974 34 87% 10
8 MACKOVA, E , HRUSKOVA, K , BENDOVA, P , VAVROVA, A , JANSOVA, H , HASKOVA, P , KOVARIKOVA, P , VAVROVA, K , SIMUNEK, T , (2012) METHYL AND ETHYL KETONE ANALOGS OF SALICYLALDEHYDE ISONICOTINOYL HYDRAZONE: NOVEL IRON CHELATORS WITH SELECTIVE ANTIPROLIFERATIVE ACTION.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 197. ISSUE 2-3. P. 69 -79 45 67% 14
9 STEFANI, C , PUNNIA-MOORTHY, G , LOVEJOY, DB , JANSSON, PJ , KALINOWSKI, DS , SHARPE, PC , BERNHARDT, PV , RICHARDSON, DR , (2011) HALOGENATED 2 '-BENZOYLPYRIDINE THIOSEMICARBAZONE (XBPT) CHELATORS WITH POTENT AND SELECTIVE ANTI-NEOPLASTIC ACTIVITY: RELATIONSHIP TO INTRACELLULAR REDOX ACTIVITY.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 54. ISSUE 19. P. 6936 -6948 38 81% 13
10 KALINOWSKI, DS , RICHARDSON, DR , (2005) THE EVOLUTION OF IRON CHELATORS FOR THE TREATMENT OF IRON OVERLOAD DISEASE AND CANCER.PHARMACOLOGICAL REVIEWS. VOL. 57. ISSUE 4. P. 547-583 74 34% 362

Classes with closest relation at Level 1


Rank Class id link
1 27518 CHIMIOSENSIBIL PALUDISME//MULTIDENTATE AMINOTHIOLS//MEROZOITE RELEASE
2 24054 PLACENTAL ISOFERRITIN//P43 ISOFERRITIN//PLACENTAL FERRITIN
3 21036 NDRG2//NDRG1//N MYC DOWNSTREAM REGULATED GENE 2
4 6139 TRANSFERRIN RECEPTOR//TRANSFERRIN//DOXORUBICIN TRANSFERRIN CONJUGATE
5 24198 BETA THALASSEMIA HEMOGLOBIN E//BETA THALASSEMIC//CD1A LYMPHOCYTE
6 23361 FERRIC NITRILOTRIACETATE//SECT CHEMOPREVENT NUTR TOXICOL//PATHOL BIOL PONSES
7 16711 HYDROXYPYRIDINONE//3 HYDROXY 4 PYRIDINONES//3 HYDROXYPYRIDIN 4 ONE
8 9458 IRON REGULATORY PROTEIN//IRON RESPONSIVE ELEMENT//IRON REGULATORY PROTEIN 1
9 928 IRON OVERLOAD//DEFERASIROX//THALASSEMIA
10 1720 THIOSEMICARBAZONE//THIOSEMICARBAZONE COMPLEXES//BISTHIOSEMICARBAZONE

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