Class information for:
Level 1: 17 BETA HYDROXYSTEROID DEHYDROGENASE//17 BETA HSD2//17 BETA HSD1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13102 860 37.6 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
159 3       MENOPAUSE//ISOFLAVONES//TAMOXIFEN 61134
1407 2             2 METHOXYESTRADIOL//STEROID SULFATASE//17 BETA HYDROXYSTEROID DEHYDROGENASE 8029
13102 1                   17 BETA HYDROXYSTEROID DEHYDROGENASE//17 BETA HSD2//17 BETA HSD1 860

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 17 BETA HYDROXYSTEROID DEHYDROGENASE authKW 1851625 13% 45% 116
2 17 BETA HSD2 authKW 461562 2% 100% 13
3 17 BETA HSD1 authKW 409344 2% 82% 14
4 17 BETA HSD authKW 380600 3% 40% 27
5 HYDROXYSTEROID DEHYDROGENASE authKW 324163 5% 21% 44
6 HSD17B1 authKW 319531 2% 60% 15
7 ONCOL MOL ENDOCRINOL address 252920 5% 15% 47
8 17 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 authKW 221897 1% 63% 10
9 HSD17B2 authKW 162301 1% 57% 8
10 ABORATING REPROD HLTH address 162154 2% 35% 13

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Endocrinology & Metabolism 12156 46% 0% 393
2 Biochemistry & Molecular Biology 1868 40% 0% 345
3 Chemistry, Medicinal 1466 13% 0% 110
4 Cell Biology 427 13% 0% 113
5 Oncology 82 7% 0% 62
6 Chemistry, Organic 67 6% 0% 49
7 Biophysics 56 4% 0% 35
8 Obstetrics & Gynecology 45 3% 0% 26
9 Reproductive Biology 24 1% 0% 12
10 Toxicology 18 2% 0% 19

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOL MOL ENDOCRINOL 252920 5% 15% 47
2 ABORATING REPROD HLTH 162154 2% 35% 13
3 GRP MOL ENDOCRINOL 127647 2% 28% 13
4 EXPT GENET 125762 6% 7% 48
5 ENDOCRINOL GENOM UNIT 91291 1% 43% 6
6 STERIX LTD 79983 2% 17% 13
7 WHO ABORATING REPROD HLTH 68272 1% 38% 5
8 GENOME ANAL 65933 4% 5% 35
9 ONCOL DRUG DISCOVERY WOMENS HLTH GRP 56803 0% 40% 4
10 LEHRSTUHL EXPT GENET 53682 1% 14% 11

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 58752 14% 1% 122
2 MOLECULAR AND CELLULAR ENDOCRINOLOGY 23709 9% 1% 76
3 STEROIDS 7831 4% 1% 31
4 JOURNAL OF MOLECULAR ENDOCRINOLOGY 2852 2% 1% 13
5 LETTERS IN DRUG DESIGN & DISCOVERY 2119 1% 1% 9
6 CHEMICO-BIOLOGICAL INTERACTIONS 1789 2% 0% 17
7 ENDOCRINOLOGY 1611 4% 0% 34
8 JOURNAL OF ENDOCRINOLOGY 1514 2% 0% 19
9 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 1464 1% 0% 9
10 MOLECULAR ENDOCRINOLOGY 1397 2% 0% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 17 BETA HYDROXYSTEROID DEHYDROGENASE 1851625 13% 45% 116 Search 17+BETA+HYDROXYSTEROID+DEHYDROGENASE Search 17+BETA+HYDROXYSTEROID+DEHYDROGENASE
2 17 BETA HSD2 461562 2% 100% 13 Search 17+BETA+HSD2 Search 17+BETA+HSD2
3 17 BETA HSD1 409344 2% 82% 14 Search 17+BETA+HSD1 Search 17+BETA+HSD1
4 17 BETA HSD 380600 3% 40% 27 Search 17+BETA+HSD Search 17+BETA+HSD
5 HYDROXYSTEROID DEHYDROGENASE 324163 5% 21% 44 Search HYDROXYSTEROID+DEHYDROGENASE Search HYDROXYSTEROID+DEHYDROGENASE
6 HSD17B1 319531 2% 60% 15 Search HSD17B1 Search HSD17B1
7 17 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 221897 1% 63% 10 Search 17+BETA+HYDROXYSTEROID+DEHYDROGENASE+TYPE+1 Search 17+BETA+HYDROXYSTEROID+DEHYDROGENASE+TYPE+1
8 HSD17B2 162301 1% 57% 8 Search HSD17B2 Search HSD17B2
9 NON STEROIDAL INHIBITORS 151480 1% 53% 8 Search NON+STEROIDAL+INHIBITORS Search NON+STEROIDAL+INHIBITORS
10 17 BETA HSD3 147935 1% 83% 5 Search 17+BETA+HSD3 Search 17+BETA+HSD3

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DAY, JM , TUTILL, HJ , PUROHIT, A , REED, MJ , (2008) DESIGN AND VALIDATION OF SPECIFIC INHIBITORS OF 17 BETA-HYDROXYSTEROID DEHYDROGENASES FOR THERAPEUTIC APPLICATION IN BREAST AND PROSTATE CANCER, AND IN ENDOMETRIOSIS.ENDOCRINE-RELATED CANCER. VOL. 15. ISSUE 3. P. 665 -692 117 55% 73
2 MARCHAIS-OBERWINKLER, S , HENN, C , MOLLER, G , KLEIN, T , NEGRI, M , OSTER, A , SPADARO, A , WERTH, R , WETZEL, M , XU, KY , ET AL (2011) 17 BETA-HYDROXYSTEROID DEHYDROGENASES (17 BETA-HSDS) AS THERAPEUTIC TARGETS: PROTEIN STRUCTURES, FUNCTIONS, AND RECENT PROGRESS IN INHIBITOR DEVELOPMENT.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 125. ISSUE 1-2. P. 66-82 79 61% 55
3 DAY, JM , TUTILL, HJ , PUROHIT, A , (2010) 17 BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS.MINERVA ENDOCRINOLOGICA. VOL. 35. ISSUE 2. P. 87 -108 99 57% 12
4 POIRIER, D , (2010) 17 BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS: A PATENT REVIEW.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 20. ISSUE 9. P. 1123 -1145 64 78% 24
5 POIRIER, D , (2011) CONTRIBUTION TO THE DEVELOPMENT OF INHIBITORS OF 17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPES 1 AND 7: KEY TOOLS FOR STUDYING AND TREATING ESTROGEN-DEPENDENT DISEASES.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 125. ISSUE 1-2. P. 83 -94 64 76% 13
6 POIRIER, D , (2003) INHIBITORS OF 17 BETA-HYDROXYSTEROID DEHYDROGENASES.CURRENT MEDICINAL CHEMISTRY. VOL. 10. ISSUE 6. P. 453-477 71 73% 118
7 JARVENSIVU, P , SALONIEMI-HEINONEN, T , AWOSANYA, M , KOSKIMIES, P , SAARINEN, N , POUTANEN, M , (2015) HSD17B1 EXPRESSION ENHANCES ESTROGEN SIGNALING STIMULATED BY THE LOW ACTIVE ESTRONE, EVIDENCED BY AN ESTROGEN RESPONSIVE ELEMENT-DRIVEN REPORTER GENE IN VIVO.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 234. ISSUE . P. 126 -134 56 71% 0
8 HE, WH , GAURI, M , LI, T , WANG, RX , LIN, SX , (2016) CURRENT KNOWLEDGE OF THE MULTIFUNCTIONAL 17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (HSD17B1).GENE. VOL. 588. ISSUE 1. P. 54 -61 57 67% 0
9 POIRIER, D , BOIVIN, RP , TREMBLAY, MR , BERUBE, M , QIU, W , LIN, SX , (2005) ESTRADIOL-ADENOSINE HYBRID COMPOUNDS DESIGNED TO INHIBIT TYPE 1 17-BETA-HYDROXYSTEROID DEHYDROGENASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 48. ISSUE 26. P. 8134 -8147 54 78% 48
10 PELTOKETO, H , LUU-THE, V , SIMARD, J , ADAMSKI, J , (1999) 17 BETA-HYDROXYSTEROID DEHYDROGENASE (HSD)/17-KETOSTEROID REDUCTASE (KSR) FAMILY; NOMENCLATURE AND MAIN CHARACTERISTICS OF THE 17HSD/KSR ENZYMES.JOURNAL OF MOLECULAR ENDOCRINOLOGY. VOL. 23. ISSUE 1. P. 1 -11 55 73% 188

Classes with closest relation at Level 1


Rank Class id link
1 10359 CARBONYL REDUCTASE//ALDO KETO REDUCTASE//DIHYDRODIOL DEHYDROGENASE
2 24408 3 BETA HYDROXYSTEROID DEHYDROGENASE//HSD3B2 GENE//SHORT CHAIN OXIDOREDUCTASE
3 10772 AROMATASE//JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY//METAB CANC
4 12125 STEROID SULFATASE//X LINKED ICHTHYOSIS//ESTRONE SULFATASE
5 13518 STEROIDS//STEROIDAL OXIMES//HETEROSTEROIDS
6 31199 HLTH SCI SW MED BIOCHEM//HLTH SCI SW MED OBSTET GYNECOL//20A DIHYDROPROGESTERONE
7 14230 BETA KETOTHIOLASE DEFICIENCY//MITOCHONDRIAL ACETOACETYL COA THIOLASE//THIOLASE
8 5864 FINASTERIDE//5 ALPHA REDUCTASE//5 ALPHA REDUCTASE INHIBITORS
9 28672 DHEA FATTY ACID ESTERS//MILK CORTISOL//NEUROMUSCULAR LOCOMOTOR DEVELOPMENT
10 10093 BREAST CYST FLUID//APOCRINE CARCINOMA//PROLACTIN INDUCIBLE PROTEIN

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