Class information for:
Level 2: 2 METHOXYESTRADIOL//STEROID SULFATASE//17 BETA HYDROXYSTEROID DEHYDROGENASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1407 8029 36.5 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
159 3       MENOPAUSE//ISOFLAVONES//TAMOXIFEN 61134
1407 2             2 METHOXYESTRADIOL//STEROID SULFATASE//17 BETA HYDROXYSTEROID DEHYDROGENASE 8029
5815 1                   CATECHOLESTROGENS//16 ALPHA HYDROXYESTRONE//ESTROGEN METABOLITES 1571
10093 1                   BREAST CYST FLUID//APOCRINE CARCINOMA//PROLACTIN INDUCIBLE PROTEIN 1093
10359 1                   CARBONYL REDUCTASE//ALDO KETO REDUCTASE//DIHYDRODIOL DEHYDROGENASE 1070
10772 1                   AROMATASE//JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY//METAB CANC 1036
12125 1                   STEROID SULFATASE//X LINKED ICHTHYOSIS//ESTRONE SULFATASE 930
13102 1                   17 BETA HYDROXYSTEROID DEHYDROGENASE//17 BETA HSD2//17 BETA HSD1 860
14933 1                   CYP1B1//CYP2S1//CYP2W1 741
18998 1                   2 METHOXYESTRADIOL//2 METHOXYOESTRADIOL//2 METHOXYESTRADIOL BIS SULPHAMATE 527
28672 1                   DHEA FATTY ACID ESTERS//MILK CORTISOL//NEUROMUSCULAR LOCOMOTOR DEVELOPMENT 201

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 2 METHOXYESTRADIOL authKW 555969 2% 76% 192
2 STEROID SULFATASE authKW 297505 1% 72% 108
3 17 BETA HYDROXYSTEROID DEHYDROGENASE authKW 288645 2% 54% 140
4 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY journal 241781 9% 8% 757
5 AROMATASE authKW 230550 4% 18% 337
6 CATECHOLESTROGENS authKW 203371 1% 63% 85
7 STERIX LTD address 194802 1% 83% 62
8 X LINKED ICHTHYOSIS authKW 128470 0% 87% 39
9 CARBONYL REDUCTASE authKW 120937 1% 40% 80
10 CYP1B1 authKW 116071 1% 30% 103

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Endocrinology & Metabolism 38330 27% 1% 2179
2 Oncology 15016 24% 0% 1901
3 Biochemistry & Molecular Biology 7775 29% 0% 2298
4 Chemistry, Medicinal 2211 6% 0% 453
5 Toxicology 1709 5% 0% 411
6 Pharmacology & Pharmacy 1285 10% 0% 798
7 Obstetrics & Gynecology 853 4% 0% 315
8 Cell Biology 652 7% 0% 539
9 Pathology 510 3% 0% 238
10 Reproductive Biology 431 2% 0% 144

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STERIX LTD 194802 1% 83% 62
2 ONCOL MOL ENDOCRINOL 68860 1% 24% 75
3 ENDOCRINOL METAB MED STERIX LTD 57240 0% 94% 16
4 EXCELLENCE ENVIRONM TOXICOL 45318 1% 25% 47
5 MED CHEM STERIX LTD 38012 0% 100% 10
6 ONCOENDOCRINOL 29303 0% 43% 18
7 ONCOL DRUG DISCOVERY WOMENS HLTH GRP 24324 0% 80% 8
8 ENDOCRINOL GENOM UNIT 21986 0% 64% 9
9 MED CHEM PHARMACOGNOSY MC 781 21896 0% 41% 14
10 GRP MOL ENDOCRINOL 20683 0% 34% 16

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 241781 9% 8% 757
2 STEROIDS 40994 3% 5% 217
3 MOLECULAR AND CELLULAR ENDOCRINOLOGY 13666 2% 2% 178
4 BREAST CANCER RESEARCH AND TREATMENT 12377 2% 2% 155
5 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 7528 1% 2% 113
6 ENDOCRINE-RELATED CANCER 5890 1% 3% 51
7 CARCINOGENESIS 4596 2% 1% 121
8 CHEMICO-BIOLOGICAL INTERACTIONS 4490 1% 1% 83
9 CHEMICAL RESEARCH IN TOXICOLOGY 4200 1% 1% 77
10 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 3895 2% 1% 161

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 2 METHOXYESTRADIOL 555969 2% 76% 192 Search 2+METHOXYESTRADIOL Search 2+METHOXYESTRADIOL
2 STEROID SULFATASE 297505 1% 72% 108 Search STEROID+SULFATASE Search STEROID+SULFATASE
3 17 BETA HYDROXYSTEROID DEHYDROGENASE 288645 2% 54% 140 Search 17+BETA+HYDROXYSTEROID+DEHYDROGENASE Search 17+BETA+HYDROXYSTEROID+DEHYDROGENASE
4 AROMATASE 230550 4% 18% 337 Search AROMATASE Search AROMATASE
5 CATECHOLESTROGENS 203371 1% 63% 85 Search CATECHOLESTROGENS Search CATECHOLESTROGENS
6 X LINKED ICHTHYOSIS 128470 0% 87% 39 Search X+LINKED+ICHTHYOSIS Search X+LINKED+ICHTHYOSIS
7 CARBONYL REDUCTASE 120937 1% 40% 80 Search CARBONYL+REDUCTASE Search CARBONYL+REDUCTASE
8 CYP1B1 116071 1% 30% 103 Search CYP1B1 Search CYP1B1
9 ALDO KETO REDUCTASE 107867 1% 30% 94 Search ALDO+KETO+REDUCTASE Search ALDO+KETO+REDUCTASE
10 ESTROGEN METABOLISM 104953 1% 47% 59 Search ESTROGEN+METABOLISM Search ESTROGEN+METABOLISM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 REED, MJ , PUROHIT, A , WOO, LWL , NEWMAN, SP , POTTER, BVL , (2005) STEROID SULFATASE: MOLECULAR BIOLOGY, REGULATION, AND INHIBITION.ENDOCRINE REVIEWS. VOL. 26. ISSUE 2. P. 171-202 184 72% 267
2 KUMAR, BS , RAGHUVANSHI, DS , HASANAIN, M , ALAM, S , SARKAR, J , MITRA, K , KHAN, F , NEGI, AS , (2016) RECENT ADVANCES IN CHEMISTRY AND PHARMACOLOGY OF 2-METHOXYESTRADIOL: AN ANTICANCER INVESTIGATIONAL DRUG.STEROIDS. VOL. 110. ISSUE . P. 9 -34 138 80% 2
3 ZHU, BT , CONNEY, AH , (1998) FUNCTIONAL ROLE OF ESTROGEN METABOLISM IN TARGET CELLS: REVIEW AND PERSPECTIVES.CARCINOGENESIS. VOL. 19. ISSUE 1. P. 1 -27 182 60% 642
4 THOMAS, MP , POTTER, BVL , (2015) DISCOVERY AND DEVELOPMENT OF THE ARYL O-SULFAMATE PHARMACOPHORE FOR ONCOLOGY AND WOMEN'S HEALTH.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 19. P. 7634 -7658 136 77% 1
5 MCNAMARA, KM , MOORE, NL , HICKEY, TE , SASANO, H , TILLEY, WD , (2014) COMPLEXITIES OF ANDROGEN RECEPTOR SIGNALLING IN BREAST CANCER.ENDOCRINE-RELATED CANCER. VOL. 21. ISSUE 4. P. T161 -T181 127 70% 18
6 PEYRAT, JF , BRION, JD , ALAMI, M , (2012) SYNTHETIC 2-METHOXYESTRADIOL DERIVATIVES: STRUCTURE-ACTIVITY RELATIONSHIPS.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 24. P. 4142-4156 113 86% 15
7 DAY, JM , TUTILL, HJ , PUROHIT, A , REED, MJ , (2008) DESIGN AND VALIDATION OF SPECIFIC INHIBITORS OF 17 BETA-HYDROXYSTEROID DEHYDROGENASES FOR THERAPEUTIC APPLICATION IN BREAST AND PROSTATE CANCER, AND IN ENDOMETRIOSIS.ENDOCRINE-RELATED CANCER. VOL. 15. ISSUE 3. P. 665 -692 144 68% 73
8 SAMAVAT, H , KURZER, MS , (2015) ESTROGEN METABOLISM AND BREAST CANCER.CANCER LETTERS. VOL. 356. ISSUE 2. P. 231 -243 101 78% 13
9 DAY, JM , TUTILL, HJ , PUROHIT, A , (2010) 17 BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS.MINERVA ENDOCRINOLOGICA. VOL. 35. ISSUE 2. P. 87 -108 130 74% 12
10 NUSSBAUMER, P , BILLICH, A , (2004) STEROID SULFATASE INHIBITORS.MEDICINAL RESEARCH REVIEWS. VOL. 24. ISSUE 4. P. 529-576 125 81% 67

Classes with closest relation at Level 2


Rank Class id link
1 3208 DEHYDROEPIANDROSTERONE//DHEA//DEHYDROEPIANDROSTERONE SULFATE
2 329 TAMOXIFEN//ESTROGEN RECEPTOR//AROMATASE INHIBITORS
3 3044 SULFOTRANSFERASE//LYSYL OXIDASE//SULT
4 3560 DIETHYLSTILBESTROL//VAGINAL ADENOSIS//VAGINAL ADENOCARCINOMA
5 827 MAMMOGRAPHIC DENSITY//BREAST DENSITY//METFORMIN
6 1973 ANABOLIC STEROIDS//DOPING CONTROL//DOPING ANALYSIS
7 2198 ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//DIABETIC NEUROPATHY
8 3688 LIPOCALIN 2//APOLIPOPROTEIN D//ZINC ALPHA 2 GLYCOPROTEIN
9 1741 GSTM1//GSTT1//GLUTATHIONE S TRANSFERASE
10 1738 BRASSINOSTEROIDS//24 EPIBRASSINOLIDE//BRASSINOLIDE

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