Class information for:
Level 2: ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//DIABETIC NEUROPATHY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2198 4878 40.8 70%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
14 4 ORTHOPEDICS//DENTISTRY, ORAL SURGERY & MEDICINE//SPORT SCIENCES 808941
444 3       CARPAL TUNNEL SYNDROME//MEDIAN NERVE//ALDOSE REDUCTASE 26401
2198 2             ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//DIABETIC NEUROPATHY 4878
2099 1                   DIABETIC NEUROPATHY//NERVE BLOOD FLOW//VASA NERVORUM 2357
2952 1                   ALDOSE REDUCTASE//ALDOSE REDUCTASE INHIBITOR//AKR1B10 2104
24507 1                   C PEPTIDE//PROINSULIN C PEPTIDE//SECT CLIN PHYSIOL 309
34694 1                   TRANSFUSION GELATIN//BALLISTOCONIDIA//CELL IRON DISTRIBUTION 108

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ALDOSE REDUCTASE authKW 1862304 10% 63% 469
2 ALDOSE REDUCTASE INHIBITOR authKW 912128 4% 67% 218
3 DIABETIC NEUROPATHY authKW 669915 8% 26% 407
4 POLYOL PATHWAY authKW 564524 3% 66% 136
5 NERVE BLOOD FLOW authKW 289793 1% 75% 62
6 AKR1B10 authKW 285547 1% 89% 51
7 ALDO KETO REDUCTASE authKW 213335 2% 33% 103
8 OCULAR THER EUT address 130331 1% 77% 27
9 C PEPTIDE authKW 121263 3% 15% 128
10 VASA NERVORUM authKW 111250 1% 66% 27

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Endocrinology & Metabolism 18095 24% 0% 1175
2 Neurosciences 4103 19% 0% 918
3 Chemistry, Medicinal 2145 7% 0% 337
4 Clinical Neurology 1956 10% 0% 494
5 Pharmacology & Pharmacy 1856 14% 0% 668
6 Biochemistry & Molecular Biology 1552 19% 0% 915
7 Ophthalmology 1305 5% 0% 245
8 Pathology 495 4% 0% 173
9 Biophysics 438 5% 0% 222
10 Medicine, Research & Experimental 384 5% 0% 220

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OCULAR THER EUT 130331 1% 77% 27
2 MORRIS HOOD JR COMPREHENS DIABET 101374 0% 90% 18
3 SECT CLIN PHYSIOL 35351 0% 27% 21
4 IGBMCUPR BIOL STRUCT 31290 0% 100% 5
5 PATHOL 0612 26669 0% 47% 9
6 MORRIS HOOD COMPREHENS DIABET 25032 0% 100% 4
7 SIMMONSCOOPER CANC 18195 0% 36% 8
8 JEWISH CARDIOVASC 15640 0% 50% 5
9 HARRY B AILEEN GORDON DIABET 14300 0% 57% 4
10 AATBSRB 12516 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABETES 36376 5% 2% 265
2 DIABETOLOGIA 28762 4% 2% 196
3 EXPERIMENTAL DIABESITY RESEARCH 18762 0% 33% 9
4 JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 11091 1% 5% 33
5 JOURNAL OF DIABETES AND ITS COMPLICATIONS 8949 1% 3% 51
6 EXPERIMENTAL DIABETES RESEARCH 6382 0% 6% 18
7 METABOLISM-CLINICAL AND EXPERIMENTAL 5092 2% 1% 86
8 JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 4897 1% 2% 50
9 DIABETES RESEARCH AND CLINICAL PRACTICE 4887 1% 1% 65
10 DIABETES-METABOLISM RESEARCH AND REVIEWS 4409 1% 2% 32

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ALDOSE REDUCTASE 1862304 10% 63% 469 Search ALDOSE+REDUCTASE Search ALDOSE+REDUCTASE
2 ALDOSE REDUCTASE INHIBITOR 912128 4% 67% 218 Search ALDOSE+REDUCTASE+INHIBITOR Search ALDOSE+REDUCTASE+INHIBITOR
3 DIABETIC NEUROPATHY 669915 8% 26% 407 Search DIABETIC+NEUROPATHY Search DIABETIC+NEUROPATHY
4 POLYOL PATHWAY 564524 3% 66% 136 Search POLYOL+PATHWAY Search POLYOL+PATHWAY
5 NERVE BLOOD FLOW 289793 1% 75% 62 Search NERVE+BLOOD+FLOW Search NERVE+BLOOD+FLOW
6 AKR1B10 285547 1% 89% 51 Search AKR1B10 Search AKR1B10
7 ALDO KETO REDUCTASE 213335 2% 33% 103 Search ALDO+KETO+REDUCTASE Search ALDO+KETO+REDUCTASE
8 C PEPTIDE 121263 3% 15% 128 Search C+PEPTIDE Search C+PEPTIDE
9 VASA NERVORUM 111250 1% 66% 27 Search VASA+NERVORUM Search VASA+NERVORUM
10 NERVE CONDUCTION 97304 2% 18% 85 Search NERVE+CONDUCTION Search NERVE+CONDUCTION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GREWAL, AS , BHARDWAJ, S , PANDITA, D , LATHER, V , SEKHON, BS , (2016) UPDATES ON ALDOSE REDUCTASE INHIBITORS FOR MANAGEMENT OF DIABETIC COMPLICATIONS AND NON-DIABETIC DISEASES.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 2. P. 120 -162 221 74% 2
2 MACCARI, R , OTTANA, R , (2015) TARGETING ALDOSE REDUCTASE FOR THE TREATMENT OF DIABETES COMPLICATIONS AND INFLAMMATORY DISEASES: NEW INSIGHTS AND FUTURE DIRECTIONS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 5. P. 2047 -2067 132 86% 13
3 OATES, PJ , (2008) ALDOSE REDUCTASE, STILL A COMPELLING TARGET FOR DIABETIC NEUROPATHY.CURRENT DRUG TARGETS. VOL. 9. ISSUE 1. P. 14-36 143 76% 94
4 DEL CORSO, A , CAPPIELLO, M , MURA, U , (2008) FROM A DULL ENZYME TO SOMETHING ELSE: FACTS AND PERSPECTIVES REGARDING ALDOSE REDUCTASE.CURRENT MEDICINAL CHEMISTRY. VOL. 15. ISSUE 15. P. 1452-1461 146 80% 28
5 ZOCHODNE, DW , (2002) NERVE AND GANGLION BLOOD FLOW IN DIABETES: AN APPRAISAL.NEUROBIOLOGY OF DIABETIC NEUROPATHY. VOL. 50. ISSUE . P. 161 -202 140 82% 18
6 SUGIMOTO, K , MURAKAWA, Y , SIMA, AAF , (2000) DIABETIC NEUROPATHY - A CONTINUING ENIGMA.DIABETES-METABOLISM RESEARCH AND REVIEWS. VOL. 16. ISSUE 6. P. 408 -433 187 59% 87
7 OATES, PJ , (2002) POLYOL PATHWAY AND DIABETIC PERIPHERAL NEUROPATHY.NEUROBIOLOGY OF DIABETIC NEUROPATHY. VOL. 50. ISSUE . P. 325 -392 141 67% 126
8 CRABBE, MJC , GOODE, D , (1998) ALDOSE REDUCTASE: A WINDOW TO THE TREATMENT OF DIABETIC COMPLICATIONS?.PROGRESS IN RETINAL AND EYE RESEARCH. VOL. 17. ISSUE 3. P. 313 -383 158 69% 56
9 HUANG, L , HE, RZ , LUO, WH , ZHU, YS , LI, J , TAN, T , ZHANG, X , HU, Z , LUO, DX , (2016) ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 INHIBITORS: POTENTIAL DRUGS FOR CANCER TREATMENT.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 11. ISSUE 2. P. 184 -196 80 76% 2
10 YAGIHASHI, S , MIZUKAMI, H , SUGIMOTO, K , (2011) MECHANISM OF DIABETIC NEUROPATHY: WHERE ARE WE NOW AND WHERE TO GO?.JOURNAL OF DIABETES INVESTIGATION. VOL. 2. ISSUE 1. P. 18-32 100 68% 38

Classes with closest relation at Level 2


Rank Class id link
1 716 CARPAL TUNNEL SYNDROME//MEDIAN NERVE//ULNAR NERVE
2 1179 ADVANCED GLYCATION END PRODUCTS//METHYLGLYOXAL//GLYCATION
3 2464 STREPTOZOTOCIN//KANGEN KARYU//HYPERCYTOLIPIDEMIA
4 3086 NODE OF RANVIER//NERVE EXCITABILITY//AXON INITIAL SEGMENT
5 990 LENS//CATARACT//ALPHA CRYSTALLIN
6 1369 HEART RATE VARIABILITY//AUTONOMIC NERVOUS SYSTEM//DIABETIC CARDIOMYOPATHY
7 1894 CYSTINURIA//REGULATORY VOLUME DECREASE//CELL VOLUME REGULATION
8 1407 2 METHOXYESTRADIOL//STEROID SULFATASE//17 BETA HYDROXYSTEROID DEHYDROGENASE
9 1788 ALPHA LIPOIC ACID//ISOPROSTANES//LIPOIC ACID
10 3467 CITICOLINE//CDP CHOLINE//ACETYL L CARNITINE

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